INT139391
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Effect of indomethacin on Bfl-1, WISP-1 and proliferating cell nuclear antigen in colon cancer cell line HCT116 cells. | |||||||||||||||
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A normal canine lymph node was used as a positive control for PCNA. | |||||||||||||||
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PEITC significantly lowered the incidence of alveolar dysplasia in group B, but we observed no down-regulation of COX-2 expression or PCNA in this group. | |||||||||||||||
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Ghrelin receptor (GHSR-1a) and PCNA immunoreactivity were detected using the Vectastain Elite ABC kit (Vector Laboratories Ltd, Peterborough, UK) The protocol was as described above with exception of the following: the secondary antibody was a biotinylated rabbit anti-goat IgG (Vector Laboratories Ltd, Peterborough, UK) in a 1:200 dilution. | |||||||||||||||
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p27 is a CDKI that negatively regulate cyclin and its low expression results in proliferation of DNA damaged cells. | |||||||||||||||
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However, the expressions of various genes involved in cell cycle regulation
(PCNA, c-myc, CDK1, CDK4, and | |||||||||||||||
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We were particularly interested in the regulation of dual-purpose proteins like cyclin-A, p21/waf-1 and PCNA that not only regulate progression through cell cycle, but also participate in DNA repair and blockage of apoptosis. | |||||||||||||||
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The expression of cell cycle elements that regulate S-phase [proliferating cell nuclear antigen (PCNA)], the G1/S transition [cyclin dependent kinase 2 (cdk2) and cyclin E], the G2/M transition [cyclin dependent kinase (cdk1) and cyclin A], and a cell cycle arrest factor [p21/wild-type p53-activated fragment (Waf1)/Cip1 (cdk-interacting protein-1)], and Fas were verified by western immunoblot analysis of E15 cortical neuroblasts, according to our previously published protocols [9,37,93,94]. | |||||||||||||||
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The effects on the proliferation markers PCNA (proliferating cell nuclear antigen) and Ki-67, as assessed by immunohistochemistry, were also studied. | |||||||||||||||
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We found that the beta and gamma CHPKs, but not the alpha CHPKs, share at least a subset of activities with the cellular cyclin-dependent kinases (Cdks) that are key components of cell cycle regulation. | |||||||||||||||
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General Comments
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