INT139391

Context Info Confidence 0.60 First Reported 2003 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 10 Total Number 10 Disease Relevance 3.12 Pain Relevance 0.33

cell proliferation (PCNA) nucleoplasm (PCNA) nucleolus (PCNA) nucleus (PCNA) DNA binding (PCNA) transcription factor binding (PCNA)

Anatomy Link Frequency lymph node 1 neuroblasts 1 colon 1 PCNA (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 12 97.80 antagonist 10 81.08 agonist 13 80.48 cytokine 6 54.32 aspirin 35 51.36 Versed 1 50.56 Inflammatory mediators 2 45.68 Inflammation 7 8.84 alcohol 4 7.04 cerebral cortex 18 5.00

Disease Link Frequency Relevance Heat Colon Cancer 24 99.84 Cleidocranial Dysplasia 29 99.26 Cancer 141 98.28 INFLAMMATION 11 97.60 Apoptosis 190 95.72 Skin Cancer 9 94.96 Lung Cancer 21 94.32 Pancreatic Cancer 16 85.16 Cataract 19 82.32 Reprotox - General 1 5 81.92

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Anatomy

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Speculation

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Disease term

Effect of indomethacin on Bfl-1, WISP-1 and proliferating cell nuclear antigen in colon cancer cell line HCT116 cells.

Regulation (Effect) of proliferating cell nuclear antigen in colon associated with colon cancer

1) Confidence 0.60 Published 2006 Journal Chin J Dig Dis Section Title Doc Link 17054584 Disease Relevance 0.29 Pain Relevance 0.10

A normal canine lymph node was used as a positive control for PCNA.

Regulation (control) of PCNA in lymph node

2) Confidence 0.16 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.18 Pain Relevance 0

PEITC significantly lowered the incidence of alveolar dysplasia in group B, but we observed no down-regulation of COX-2 expression or PCNA in this group.

Regulation (regulation) of PCNA associated with cleidocranial dysplasia

3) Confidence 0.11 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1899177 Disease Relevance 0.70 Pain Relevance 0.05

Ghrelin receptor (GHSR-1a) and PCNA immunoreactivity were detected using the Vectastain Elite ABC kit (Vector Laboratories Ltd, Peterborough, UK) The protocol was as described above with exception of the following: the secondary antibody was a biotinylated rabbit anti-goat IgG (Vector Laboratories Ltd, Peterborough, UK) in a 1:200 dilution.

Regulation (immunoreactivity) of PCNA

4) Confidence 0.07 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0 Pain Relevance 0

p27 is a CDKI that negatively regulate cyclin and its low expression results in proliferation of DNA damaged cells.

Regulation (regulate) of cyclin

5) Confidence 0.05 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1208869 Disease Relevance 0.99 Pain Relevance 0

However, the expressions of various genes involved in cell cycle regulation (PCNA, c-myc, CDK1, CDK4, and

Regulation (regulation) of PCNA

6) Confidence 0.04 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.32 Pain Relevance 0

We were particularly interested in the regulation of dual-purpose proteins like cyclin-A, p21/waf-1 and PCNA that not only regulate progression through cell cycle, but also participate in DNA repair and blockage of apoptosis.

Regulation (regulation) of PCNA associated with apoptosis

7) Confidence 0.03 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.31 Pain Relevance 0

The expression of cell cycle elements that regulate S-phase [proliferating cell nuclear antigen (PCNA)], the G1/S transition [cyclin dependent kinase 2 (cdk2) and cyclin E], the G2/M transition [cyclin dependent kinase (cdk1) and cyclin A], and a cell cycle arrest factor [p21/wild-type p53-activated fragment (Waf1)/Cip1 (cdk-interacting protein-1)], and Fas were verified by western immunoblot analysis of E15 cortical neuroblasts, according to our previously published protocols [9,37,93,94].

Regulation (regulate) of PCNA in neuroblasts

8) Confidence 0.03 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0 Pain Relevance 0

The effects on the proliferation markers PCNA (proliferating cell nuclear antigen) and Ki-67, as assessed by immunohistochemistry, were also studied.

Regulation (effects) of PCNA

9) Confidence 0.02 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC156658 Disease Relevance 0.14 Pain Relevance 0.17

We found that the beta and gamma CHPKs, but not the alpha CHPKs, share at least a subset of activities with the cellular cyclin-dependent kinases (Cdks) that are key components of cell cycle regulation.

Regulation (regulation) of cyclin

10) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2936540 Disease Relevance 0.20 Pain Relevance 0

General Comments

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