INT139391

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Context Info
Confidence 0.60
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 3.12
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (PCNA) nucleoplasm (PCNA) nucleolus (PCNA)
nucleus (PCNA) DNA binding (PCNA) transcription factor binding (PCNA)
Anatomy Link Frequency
lymph node 1
neuroblasts 1
colon 1
PCNA (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 12 97.80 Very High Very High Very High
antagonist 10 81.08 Quite High
agonist 13 80.48 Quite High
cytokine 6 54.32 Quite High
aspirin 35 51.36 Quite High
Versed 1 50.56 Quite High
Inflammatory mediators 2 45.68 Quite Low
Inflammation 7 8.84 Low Low
alcohol 4 7.04 Low Low
cerebral cortex 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 24 99.84 Very High Very High Very High
Cleidocranial Dysplasia 29 99.26 Very High Very High Very High
Cancer 141 98.28 Very High Very High Very High
INFLAMMATION 11 97.60 Very High Very High Very High
Apoptosis 190 95.72 Very High Very High Very High
Skin Cancer 9 94.96 High High
Lung Cancer 21 94.32 High High
Pancreatic Cancer 16 85.16 High High
Cataract 19 82.32 Quite High
Reprotox - General 1 5 81.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of indomethacin on Bfl-1, WISP-1 and proliferating cell nuclear antigen in colon cancer cell line HCT116 cells.
Regulation (Effect) of proliferating cell nuclear antigen in colon associated with colon cancer
1) Confidence 0.60 Published 2006 Journal Chin J Dig Dis Section Title Doc Link 17054584 Disease Relevance 0.29 Pain Relevance 0.10
A normal canine lymph node was used as a positive control for PCNA.
Regulation (control) of PCNA in lymph node
2) Confidence 0.16 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.18 Pain Relevance 0
PEITC significantly lowered the incidence of alveolar dysplasia in group B, but we observed no down-regulation of COX-2 expression or PCNA in this group.
Regulation (regulation) of PCNA associated with cleidocranial dysplasia
3) Confidence 0.11 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1899177 Disease Relevance 0.70 Pain Relevance 0.05
Ghrelin receptor (GHSR-1a) and PCNA immunoreactivity were detected using the Vectastain Elite ABC kit (Vector Laboratories Ltd, Peterborough, UK) The protocol was as described above with exception of the following: the secondary antibody was a biotinylated rabbit anti-goat IgG (Vector Laboratories Ltd, Peterborough, UK) in a 1:200 dilution.
Regulation (immunoreactivity) of PCNA
4) Confidence 0.07 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0 Pain Relevance 0
p27 is a CDKI that negatively regulate cyclin and its low expression results in proliferation of DNA damaged cells.
Regulation (regulate) of cyclin
5) Confidence 0.05 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1208869 Disease Relevance 0.99 Pain Relevance 0
However, the expressions of various genes involved in cell cycle regulation

(PCNA, c-myc, CDK1, CDK4, and

Regulation (regulation) of PCNA
6) Confidence 0.04 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.32 Pain Relevance 0
We were particularly interested in the regulation of dual-purpose proteins like cyclin-A, p21/waf-1 and PCNA that not only regulate progression through cell cycle, but also participate in DNA repair and blockage of apoptosis.
Regulation (regulation) of PCNA associated with apoptosis
7) Confidence 0.03 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.31 Pain Relevance 0
The expression of cell cycle elements that regulate S-phase [proliferating cell nuclear antigen (PCNA)], the G1/S transition [cyclin dependent kinase 2 (cdk2) and cyclin E], the G2/M transition [cyclin dependent kinase (cdk1) and cyclin A], and a cell cycle arrest factor [p21/wild-type p53-activated fragment (Waf1)/Cip1 (cdk-interacting protein-1)], and Fas were verified by western immunoblot analysis of E15 cortical neuroblasts, according to our previously published protocols [9,37,93,94].
Regulation (regulate) of PCNA in neuroblasts
8) Confidence 0.03 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0 Pain Relevance 0
The effects on the proliferation markers PCNA (proliferating cell nuclear antigen) and Ki-67, as assessed by immunohistochemistry, were also studied.
Regulation (effects) of PCNA
9) Confidence 0.02 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC156658 Disease Relevance 0.14 Pain Relevance 0.17
We found that the beta and gamma CHPKs, but not the alpha CHPKs, share at least a subset of activities with the cellular cyclin-dependent kinases (Cdks) that are key components of cell cycle regulation.
Regulation (regulation) of cyclin
10) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2936540 Disease Relevance 0.20 Pain Relevance 0

General Comments

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