INT139399
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
OBJECTIVES: To study and confirm the effect of indomethacin on the expression of Bfl-1, WISP-1 and PCNA in human colon cancer line HCT116 cells and the COX-2 independent tumor inhibiting pathway. | |||||||||||||||
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Moreover, the timing of peak SOCS3 expression coincides with the peak in satellite cell number and the down-regulation of cyclin D1 expression. | |||||||||||||||
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Changes in the expression of proliferating cell nuclear antigen, Fas, progesterone receptor (PRA) and estrogen receptor alpha (ER-alpha) were analyzed by immunohistochemistry. | |||||||||||||||
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Fangchinoline induced G1/S arrest by modulating expression of p27, PCNA, and cyclin D in human prostate carcinoma cancer PC3 cells and tumor xenograft. | |||||||||||||||
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RESULTS: Indomethacin down-regulated the expression of Bfl-1, WISP-1 and PCNA mRNA in vitro (9.53 +/- 0.15 vs 27.87 +/- 0.12, 7.37 +/- 0.58 vs 20.17 +/- 0.58, 5.17 +/- 0.06 vs 0.87 +/- 0.06). | |||||||||||||||
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COX-2, p63 and PCNA expression in preneoplastic lesions in the NNK-treated rats | |||||||||||||||
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COX-2, p63 and PCNA expression in preneoplastic lesions in the NNK-treated rats | |||||||||||||||
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PEITC significantly lowered the incidence of alveolar dysplasia in group B, but we observed no down-regulation of COX-2 expression or PCNA in this group. | |||||||||||||||
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Densitometric analysis of data from 3 experiments similar to that shown in Figure 2B revealed no significant effect of 4-AP treatment on the expression of proliferating cell nuclear antigen (PCNA). | |||||||||||||||
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One-way ANOVA followed by Dunnett's T3 test was used to evaluate the changes of PCNA protein expression among the groups. | |||||||||||||||
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We therefore examined if Fas activation and estrogen could interact to regulate the expression of cyclin A, PCNA and p21/waf-1 and compared the expression of these anti-apoptotic cell cycle proteins with other cell-cycle proteins. | |||||||||||||||
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Millar et al153 studied the impact of both the G/A870 polymorphism and cyclin D1b protein production on breast cancer risk, disease phenotype and patient outcome. | |||||||||||||||
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We therefore hypothesized that in the context of Fas activation, estrogen would alter the expression of specific cell-cycle related proteins such as Cyclin-A [50], the Proliferating Cell Nuclear Antigen (PCNA, [51,52]) and p21/waf-1 [53], that also serve anti-apoptotic and DNA repair functions in addition to their roles in cell cycle. | |||||||||||||||
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PAB induced growth inhibition and apoptosis in HT-29 cells, which were associated with cell cycle arrest at the G(2)/M phase, modulation of cyclin expression and downregulation of the protooncogene c-myc. | |||||||||||||||
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General Comments
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