INT139399

Context Info Confidence 0.56 First Reported 2003 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 14 Total Number 14 Disease Relevance 6.06 Pain Relevance 0.43

cell proliferation (PCNA) nucleoplasm (PCNA) nucleolus (PCNA) nucleus (PCNA) DNA binding (PCNA) transcription factor binding (PCNA)

Anatomy Link Frequency HT-29 2 satellite cell 2 colon 2 apoptotic cell 2 PCNA (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 5 86.32 antagonist 15 77.76 cINOD 12 75.00 aspirin 136 57.28 cytokine 18 54.32 endometriosis 2 50.00 Inflammatory mediators 8 45.68 withdrawal 2 45.60 COX2 1 25.00 Inflammation 10 8.84

Disease Link Frequency Relevance Heat Breast Cancer 123 99.84 Cleidocranial Dysplasia 116 99.26 Disease 22 99.04 Prostate Cancer 1 99.04 Apoptosis 169 98.34 Cancer 169 98.32 Reprotox - General 1 9 96.76 Colon Cancer 7 95.40 Malignant Neoplastic Disease 7 94.76 Lung Cancer 80 94.32

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

OBJECTIVES: To study and confirm the effect of indomethacin on the expression of Bfl-1, WISP-1 and PCNA in human colon cancer line HCT116 cells and the COX-2 independent tumor inhibiting pathway.

Regulation (effect) of Gene_expression (expression) of PCNA in colon

1) Confidence 0.56 Published 2006 Journal Chin J Dig Dis Section Body Doc Link 17054584 Disease Relevance 0.10 Pain Relevance 0

Moreover, the timing of peak SOCS3 expression coincides with the peak in satellite cell number and the down-regulation of cyclin D1 expression.

Regulation (regulation) of Gene_expression (expression) of cyclin in satellite cell

2) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.05 Pain Relevance 0

Changes in the expression of proliferating cell nuclear antigen, Fas, progesterone receptor (PRA) and estrogen receptor alpha (ER-alpha) were analyzed by immunohistochemistry.

Regulation (Changes) of Gene_expression (expression) of proliferating cell nuclear antigen

3) Confidence 0.44 Published 2009 Journal Hum. Reprod. Section Body Doc Link 19661125 Disease Relevance 0.17 Pain Relevance 0

Fangchinoline induced G1/S arrest by modulating expression of p27, PCNA, and cyclin D in human prostate carcinoma cancer PC3 cells and tumor xenograft.

Regulation (modulating) of Gene_expression (expression) of PCNA associated with cancer and prostate cancer

4) Confidence 0.31 Published 2010 Journal Biosci. Biotechnol. Biochem. Section Title Doc Link 20208355 Disease Relevance 1.24 Pain Relevance 0.09

RESULTS: Indomethacin down-regulated the expression of Bfl-1, WISP-1 and PCNA mRNA in vitro (9.53 +/- 0.15 vs 27.87 +/- 0.12, 7.37 +/- 0.58 vs 20.17 +/- 0.58, 5.17 +/- 0.06 vs 0.87 +/- 0.06).

Regulation (regulated) of Gene_expression (expression) of PCNA mRNA

5) Confidence 0.25 Published 2006 Journal Chin J Dig Dis Section Body Doc Link 17054584 Disease Relevance 0.07 Pain Relevance 0

COX-2, p63 and PCNA expression in preneoplastic lesions in the NNK-treated rats

Regulation (treated) of Gene_expression (expression) of PCNA

6) Confidence 0.12 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1899177 Disease Relevance 0.45 Pain Relevance 0

COX-2, p63 and PCNA expression in preneoplastic lesions in the NNK-treated rats

Regulation (lesions) of Gene_expression (expression) of PCNA

7) Confidence 0.12 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1899177 Disease Relevance 0.45 Pain Relevance 0

PEITC significantly lowered the incidence of alveolar dysplasia in group B, but we observed no down-regulation of COX-2 expression or PCNA in this group.

Regulation (regulation) of Gene_expression (expression) of PCNA associated with cleidocranial dysplasia

8) Confidence 0.11 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1899177 Disease Relevance 0.70 Pain Relevance 0.05

Densitometric analysis of data from 3 experiments similar to that shown in Figure 2B revealed no significant effect of 4-AP treatment on the expression of proliferating cell nuclear antigen (PCNA).

Neg (no) Regulation (effect) of Gene_expression (expression) of PCNA

9) Confidence 0.10 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC155641 Disease Relevance 0.17 Pain Relevance 0

One-way ANOVA followed by Dunnett's T3 test was used to evaluate the changes of PCNA protein expression among the groups.

Regulation (changes) of Gene_expression (expression) of PCNA

10) Confidence 0.07 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1899177 Disease Relevance 0.32 Pain Relevance 0.06

We therefore examined if Fas activation and estrogen could interact to regulate the expression of cyclin A, PCNA and p21/waf-1 and compared the expression of these anti-apoptotic cell cycle proteins with other cell-cycle proteins.

Regulation (regulate) of Gene_expression (expression) of PCNA in apoptotic cell associated with apoptosis

11) Confidence 0.05 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.58 Pain Relevance 0.03

Millar et al153 studied the impact of both the G/A870 polymorphism and cyclin D1b protein production on breast cancer risk, disease phenotype and patient outcome.

Regulation (impact) of Gene_expression (production) of cyclin associated with breast cancer and disease

12) Confidence 0.04 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.59 Pain Relevance 0

We therefore hypothesized that in the context of Fas activation, estrogen would alter the expression of specific cell-cycle related proteins such as Cyclin-A [50], the Proliferating Cell Nuclear Antigen (PCNA, [51,52]) and p21/waf-1 [53], that also serve anti-apoptotic and DNA repair functions in addition to their roles in cell cycle.

Regulation (alter) of Gene_expression (expression) of PCNA associated with apoptosis

13) Confidence 0.02 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.51 Pain Relevance 0.07

PAB induced growth inhibition and apoptosis in HT-29 cells, which were associated with cell cycle arrest at the G(2)/M phase, modulation of cyclin expression and downregulation of the protooncogene c-myc.

Regulation (modulation) of Gene_expression (expression) of cyclin in HT-29 associated with apoptosis

14) Confidence 0.01 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17258704 Disease Relevance 0.65 Pain Relevance 0.14

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