INT139440

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Context Info
Confidence 0.04
First Reported 2002
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.86
Pain Relevance 3.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Blmh) nucleus (Blmh) cytoplasm (Blmh)
Anatomy Link Frequency
nerve 1
Blmh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Tetrahydrobiopterin 36 100.00 Very High Very High Very High
GCH1 10 98.94 Very High Very High Very High
IPN 4 98.56 Very High Very High Very High
Inflammation 8 95.36 Very High Very High Very High
Pain 12 92.68 High High
Catecholamine 2 91.76 High High
Serotonin 2 90.56 High High
cINOD 90 84.72 Quite High
backache 2 71.84 Quite High
Bile 9 49.64 Quite Low
Disease Link Frequency Relevance Heat
Ulcers 60 99.56 Very High Very High Very High
Neuropathic Pain 4 99.20 Very High Very High Very High
Inflammatory Pain 4 98.56 Very High Very High Very High
Bacterial Infection 3 98.36 Very High Very High Very High
Nervous System Injury 2 97.28 Very High Very High Very High
INFLAMMATION 17 95.36 Very High Very High Very High
Pain 10 92.68 High High
Injury 2 90.68 High High
Low Back Pain 2 72.16 Quite High
Functional Bowel Disorder 3 22.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We report that GTP cyclohydrolase (GCH1), the rate-limiting enzyme for tetrahydrobiopterin (BH4) synthesis, is a key modulator of peripheral neuropathic and inflammatory pain.
Gene_expression (synthesis) of BH4 associated with tetrahydrobiopterin, ipn, neuropathic pain and gch1
1) Confidence 0.04 Published 2006 Journal Nat. Med. Section Abstract Doc Link 17057711 Disease Relevance 0.68 Pain Relevance 0.87
Inhibiting this de novo BH4 synthesis in rats attenuated neuropathic and inflammatory pain and prevented nerve injury-evoked excess nitric oxide production in the DRG, whereas administering BH4 intrathecally exacerbated pain.
Gene_expression (synthesis) of BH4 in nerve associated with pain, tetrahydrobiopterin, nervous system injury, ipn and neuropathic pain
2) Confidence 0.04 Published 2006 Journal Nat. Med. Section Abstract Doc Link 17057711 Disease Relevance 1.08 Pain Relevance 1.34
We found that injection of DAHP an inhibitor of BH4 synthesis prevented ulcer formation, although it did not alter the increased intestinal permeability induced by indomethacin.
Gene_expression (synthesis) of BH4 associated with tetrahydrobiopterin and ulcers
3) Confidence 0.02 Published 2002 Journal BMC Gastroenterol Section Body Doc Link PMC103670 Disease Relevance 0.38 Pain Relevance 0.37
The same strategy of inhibition of BH4 synthesis has been applied in this present attempt to investigate ulcer formation in indomethacin-induced intestinal ulcer.
Gene_expression (synthesis) of BH4 associated with tetrahydrobiopterin and ulcers
4) Confidence 0.02 Published 2002 Journal BMC Gastroenterol Section Body Doc Link PMC103670 Disease Relevance 0.38 Pain Relevance 0.37
A recent study has demonstrated that inhibition of BH4 synthesis reduces NO• production in vivo in experimental endotoxic shock[12].
Gene_expression (synthesis) of BH4 associated with tetrahydrobiopterin and bacterial infection
5) Confidence 0.02 Published 2002 Journal BMC Gastroenterol Section Body Doc Link PMC103670 Disease Relevance 0.34 Pain Relevance 0.42

General Comments

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