INT139443

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Context Info
Confidence 0.69
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 8.20
Pain Relevance 10.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GCH1) small molecule metabolic process (GCH1) nucleolus (GCH1)
nucleus (GCH1) protein complex assembly (GCH1) protein complex (GCH1)
Anatomy Link Frequency
white blood cells 3
leg 2
dorsal root ganglia 1
primary sensory neurons 1
GCH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
GCH1 81 100.00 Very High Very High Very High
Tetrahydrobiopterin 43 99.14 Very High Very High Very High
Pain 388 99.02 Very High Very High Very High
Inflammation 19 98.78 Very High Very High Very High
Sciatica 18 96.16 Very High Very High Very High
Serotonin 6 95.40 Very High Very High Very High
Catecholamine 6 94.96 High High
Opioid 11 94.24 High High
IPN 8 93.04 High High
backache 3 93.04 High High
Disease Link Frequency Relevance Heat
Pain 394 99.02 Very High Very High Very High
INFLAMMATION 19 98.78 Very High Very High Very High
Injury 6 98.68 Very High Very High Very High
Nerve Root Compression 9 96.16 Very High Very High Very High
Disease 8 95.48 Very High Very High Very High
Neuropathic Pain 26 94.00 High High
Cancer 5 93.52 High High
Inflammatory Pain 8 93.04 High High
Low Back Pain 3 93.04 High High
Nervous System Injury 3 90.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After axonal injury, concentrations of BH4 rose in primary sensory neurons, owing to upregulation of GCH1.
Positive_regulation (upregulation) of GCH1 in primary sensory neurons associated with tetrahydrobiopterin, injury and gch1
1) Confidence 0.69 Published 2006 Journal Nat. Med. Section Abstract Doc Link 17057711 Disease Relevance 0.96 Pain Relevance 1.17
After peripheral inflammation, BH4 also increased in dorsal root ganglia (DRGs), owing to enhanced GCH1 enzyme activity.
Positive_regulation (enhanced) of GCH1 in dorsal root ganglia associated with tetrahydrobiopterin, inflammation and gch1
2) Confidence 0.69 Published 2006 Journal Nat. Med. Section Abstract Doc Link 17057711 Disease Relevance 1.00 Pain Relevance 1.23
Healthy individuals homozygous for this haplotype exhibited reduced experimental pain sensitivity, and forskolin-stimulated immortalized leukocytes from haplotype carriers upregulated GCH1 less than did controls.
Positive_regulation (upregulated) of GCH1 in leukocytes associated with pain and gch1
3) Confidence 0.69 Published 2006 Journal Nat. Med. Section Abstract Doc Link 17057711 Disease Relevance 1.05 Pain Relevance 1.32
Ex-vivo, GCH1 upregulation and BH4 production after forskolin stimulation were reduced, while baseline BH4 concentrations were not affected.
Positive_regulation (upregulation) of GCH1
4) Confidence 0.69 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18374612 Disease Relevance 0.44 Pain Relevance 0.68
Tegeder et al. [7] reported that specific genetic variations in the GTP cyclohydrolase (GCH1) gene were associated with reduced severity of persistent leg pain in Caucasian patients with chronic radicular disease who underwent diskectomy, as well as with lower ratings of experimental pain stimuli in normal young adults.
Positive_regulation (variations) of GCH1 in leg associated with pain, gch1 and disease
5) Confidence 0.50 Published 2008 Journal Mol Pain Section Body Doc Link PMC2626574 Disease Relevance 1.56 Pain Relevance 1.83
Tegeder et al. [7] reported that specific genetic variations in the GTP cyclohydrolase (GCH1) gene were associated with reduced severity of persistent leg pain in Caucasian patients with chronic radicular disease who underwent diskectomy, as well as with lower ratings of experimental pain stimuli in normal young adults.
Positive_regulation (variations) of GTP cyclohydrolase in leg associated with pain, gch1 and disease
6) Confidence 0.50 Published 2008 Journal Mol Pain Section Body Doc Link PMC2626574 Disease Relevance 1.56 Pain Relevance 1.83
Thus, reduced GCH1 upregulation, here conferred by non-coding and non-splice site GCH1 variants known to lead to decreased tetrahydrobiopterin expression, delays the need for opioid therapy in cancer.
Positive_regulation (upregulation) of GCH1 associated with tetrahydrobiopterin, cancer, gch1 and opioid
7) Confidence 0.46 Published 2010 Journal Pain Section Abstract Doc Link 19959292 Disease Relevance 0.59 Pain Relevance 0.73
GCH1, BH4 and iNOS upregulation in white blood cells after lipopolysaccharide stimulation were decreased in carriers of the GCH1 haplotype, which verified that the genotype groups differed with respect to regulation of the biopterin pathway.
Positive_regulation (upregulation) of GCH1 in white blood cells
8) Confidence 0.46 Published 2008 Journal Eur J Pain Section Body Doc Link 18374612 Disease Relevance 0.06 Pain Relevance 0
Subjects heterozygous or
               homozygous for the pain-protective haplotype were found to show reduced upregulation
               of the GCH1 transcript in response to cAMP, resulting in lower
               levels of BH4, suggesting that altered GCH1 transcriptional
               modulation underlies the decreased pain sensitivity observed in these individuals.
Positive_regulation (upregulation) of GCH1 associated with pain and gch1
9) Confidence 0.41 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432024 Disease Relevance 0.77 Pain Relevance 1.33
GCH1, iNOS upregulation and BH4 production were assessed ex-vivo in white blood cells after lipopolysaccharide stimulation for 24 h.
Positive_regulation (upregulation) of GCH1 in white blood cells
10) Confidence 0.30 Published 2008 Journal Eur J Pain Section Body Doc Link 18374612 Disease Relevance 0.09 Pain Relevance 0

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