INT139449

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Context Info
Confidence 0.15
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.58
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (IGF2R) signal transduction (IGF2R) nucleus (IGF2R)
cytoplasm (IGF2R)
Anatomy Link Frequency
endothelium 1
IGF2R (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 24 99.84 Very High Very High Very High
Angina 4 67.88 Quite High
Inflammation 33 65.00 Quite High
depression 1 21.04 Low Low
Neuropathic pain 1 20.08 Low Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 84 99.04 Very High Very High Very High
Adhesions 5 97.32 Very High Very High Very High
Necrosis 4 95.04 Very High Very High Very High
Body Weight 4 77.48 Quite High
Apoptosis 2 71.76 Quite High
Coronary Artery Disease 4 69.16 Quite High
Cv General 3 Under Development 4 67.88 Quite High
INFLAMMATION 33 65.00 Quite High
Increased Venous Pressure Under Development 4 61.76 Quite High
Stress 2 26.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GATA3, ESR1, TFF1, TFF3 and ERBB4 were upregulated, whereas IGF2R, GATA6, EGFR and TGFA were downregulated in ER+ ERBB2-amplified tumors.
Negative_regulation (downregulated) of IGF2R associated with cancer
1) Confidence 0.15 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.86 Pain Relevance 0
In multivariable analyses, sCD40L (p < 0.001) and TNF-alpha (p = 0.011) were significantly associated with a decrease in MPRI on adenosine, as were TNF-alpha (p = 0.016) and sICAM-1 (p = 0.022) for a decrease in MPRI on acetylcholine.
Negative_regulation (decrease) of MPRI associated with adenocard
2) Confidence 0.05 Published 2006 Journal J Cardiovasc Magn Reson Section Abstract Doc Link 17060099 Disease Relevance 0.34 Pain Relevance 0.18
Serum levels above the median of all normal ranged biomarkers sCD40L, TNF-alpha, IL-6, sICAM-1 and CRP were associated with an impaired MPRI for stimulation with adenosine as well as acetylcholine.
Negative_regulation (impaired) of MPRI associated with adenocard
3) Confidence 0.05 Published 2006 Journal J Cardiovasc Magn Reson Section Abstract Doc Link 17060099 Disease Relevance 0.48 Pain Relevance 0.25
In multivariable analyses, sCD40L (p < 0.001) and TNF-alpha (p = 0.011) were significantly associated with a decrease in MPRI on adenosine, as were TNF-alpha (p = 0.016) and sICAM-1 (p = 0.022) for a decrease in MPRI on acetylcholine.
Negative_regulation (decrease) of MPRI associated with adenocard
4) Confidence 0.04 Published 2006 Journal J Cardiovasc Magn Reson Section Abstract Doc Link 17060099 Disease Relevance 0.33 Pain Relevance 0.20
Impaired MPRI correlated significantly with a decrease in coronary blood flow reserve after both endothelium-dependent (p = 0.033) and endothelium-independent (p = 0.022) stimulation.
Negative_regulation (Impaired) of MPRI in endothelium
5) Confidence 0.04 Published 2006 Journal J Cardiovasc Magn Reson Section Abstract Doc Link 17060099 Disease Relevance 0.57 Pain Relevance 0.24

General Comments

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