INT139450

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Context Info
Confidence 0.19
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.75
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (IGF2R) signal transduction (IGF2R) nucleus (IGF2R)
cytoplasm (IGF2R)
IGF2R (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 6 99.12 Very High Very High Very High
fibrosis 10 90.48 High High
cytokine 1 67.44 Quite High
Angina 1 56.20 Quite High
Inflammation 9 53.32 Quite High
Central nervous system 4 5.00 Very Low Very Low Very Low
Bile 4 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cirrhosis 110 92.72 High High
Adhesions 2 85.64 High High
Fibrosis 8 85.20 High High
Necrosis 3 83.36 Quite High
Cancer 1 83.00 Quite High
Disease 47 76.24 Quite High
Body Weight 2 65.80 Quite High
Coronary Artery Disease 1 57.48 Quite High
Cv General 3 Under Development 2 56.20 Quite High
Injury 4 55.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
M6P/IGF2R is also found in the Golgi apparatus, where it directs newly synthesized lysosomal proteins bearing M6P to the lysosome.
IGF2R Binding (found) of
1) Confidence 0.19 Published 2009 Journal Microb Cell Fact Section Body Doc Link PMC2674406 Disease Relevance 0 Pain Relevance 0
Serum levels above the median of all normal ranged biomarkers sCD40L, TNF-alpha, IL-6, sICAM-1 and CRP were associated with an impaired MPRI for stimulation with adenosine as well as acetylcholine.
MPRI Binding (associated) of associated with adenocard
2) Confidence 0.03 Published 2006 Journal J Cardiovasc Magn Reson Section Abstract Doc Link 17060099 Disease Relevance 0.48 Pain Relevance 0.25
This carrier binds to mannose-6-phosphate/insulin-like growth factor-II (M6P/IGFII) receptors (4,7–10).
M6P/IGFII Binding (binds) of
3) Confidence 0.01 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 1.26 Pain Relevance 0.11

General Comments

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