INT139459

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.57
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 0.32
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (MAX) nucleus (MAX) protein complex assembly (MAX)
cytoplasm (MAX)
MAX (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 17 99.56 Very High Very High Very High
Enkephalin 9 99.38 Very High Very High Very High
tolerance 4 90.40 High High
Opioid 8 90.00 High High
agonist 23 86.92 High High
Kappa opioid receptor 2 60.20 Quite High
Codeine 1 57.44 Quite High
Morphine 6 56.92 Quite High
cva 5 37.12 Quite Low
Inflammation 9 36.12 Quite Low
Disease Link Frequency Relevance Heat
Neuroblastoma 6 83.76 Quite High
Apoptosis 46 79.12 Quite High
Nicotine Addiction 14 50.00 Quite Low
Cancer 20 49.84 Quite Low
Necrosis 7 38.64 Quite Low
Ocular Toxicity (including Many Sub-types) 6 37.12 Quite Low
Stress 22 37.04 Quite Low
INFLAMMATION 11 36.84 Quite Low
Hemorrhage 1 29.36 Quite Low
Depression 1 8.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment of DOR cells with Tyr-d-Ala-Gly-Phe-d-Leu-enkephalin (DADL) resulted in a time-dependent decrease in the B(max) of delta-opioid receptor binding sites and immunoreactive receptor protein.
Negative_regulation (decrease) of max associated with enkephalin and opioid receptor
1) Confidence 0.57 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17159161 Disease Relevance 0 Pain Relevance 1.26
Saturation binding studies with [(3)H]diprenorphine showed that Salvinorin A (10 and 40 microM) decreased the mu-receptor B(max) and increased the K(d) in a dose-dependent nonlinear manner.
Negative_regulation (decreased) of max
2) Confidence 0.41 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17060492 Disease Relevance 0 Pain Relevance 0.21
Saturation binding studies with [(3)H]DAMGO showed that Salvinorin A (10 and 30 microM) decreased the mu-receptor B(max) and increased the K(d) in a dose-dependent nonlinear manner.
Negative_regulation (decreased) of max
3) Confidence 0.41 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17060492 Disease Relevance 0 Pain Relevance 0.20
increase in Mad-1 binding complexes which could contribute to the switch from c-Myc/Max to Mad1/Max with repressor
Negative_regulation (switch) of Max
4) Confidence 0.41 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.16 Pain Relevance 0
increase in Mad-1 binding complexes which could contribute to the switch from c-Myc/Max to Mad1/Max with repressor
Negative_regulation (switch) of Max
5) Confidence 0.41 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.16 Pain Relevance 0
In this group no reduction in Max dp/dt was observed.


Neg (no) Negative_regulation (reduction) of Max
6) Confidence 0.16 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2817881 Disease Relevance 0 Pain Relevance 0.11

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox