INT139474

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Context Info
Confidence 0.34
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 5.74
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnfrsf11b) extracellular space (Tnfrsf11b) extracellular region (Tnfrsf11b)
proteinaceous extracellular matrix (Tnfrsf11b) extracellular matrix organization (Tnfrsf11b)
Anatomy Link Frequency
osteoblast 2
joint 1
osteoclast 1
Tnfrsf11b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 11 99.60 Very High Very High Very High
Arthritis 154 98.68 Very High Very High Very High
cytokine 6 93.52 High High
nociceptor 3 83.84 Quite High
Cancer pain 22 81.84 Quite High
Pain 63 80.08 Quite High
imagery 36 64.76 Quite High
Intractable pain 2 57.92 Quite High
Inflammation 24 42.44 Quite Low
positron emission tomography 16 30.68 Quite Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 15 99.60 Very High Very High Very High
Osteoporosis 26 99.42 Very High Very High Very High
Psoriasis 44 99.08 Very High Very High Very High
Seronegative Spondarthritis 134 98.68 Very High Very High Very High
Death 3 98.44 Very High Very High Very High
Cancer 93 98.14 Very High Very High Very High
Glioma 6 97.92 Very High Very High Very High
Disease 56 97.48 Very High Very High Very High
Optic Nerve Glioma 1 94.00 High High
Hypercalcemia 23 93.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No effect on OPG by bisphosphonate therapy has been reported in subjects with osteoporosis or rheumatoid arthritis [30,31], whereas a decrease in OPG after bisphosphonates has been found in subjects with Paget's disease [30].
Negative_regulation (decrease) of OPG associated with rheumatoid arthritis, osteoporosis and disease
1) Confidence 0.34 Published 2010 Journal Nutr J Section Body Doc Link PMC2818614 Disease Relevance 0.30 Pain Relevance 0.05
Thus, both serum OPG and RANKL have been found to decrease after treatment with oestrogen in postmenopausal women in one study [28], whereas serum OPG but not RANKL increased after oral contraceptives in another study [29].
Negative_regulation (decrease) of serum OPG
2) Confidence 0.29 Published 2010 Journal Nutr J Section Body Doc Link PMC2818614 Disease Relevance 0.23 Pain Relevance 0.04
Myeloma cells upregulate RANKL and downregulate osteoprotegerin, resulting in increased osteoclastic activity.
Negative_regulation (downregulate) of osteoprotegerin associated with osteoporosis
3) Confidence 0.25 Published 2010 Journal Advances in Hematology Section Body Doc Link PMC2905716 Disease Relevance 1.03 Pain Relevance 0.05
Although 1,25(OH)2D has been demonstrated in in-vitro studies to increase RANKL expression [5] and reduce the OPG expression [9], supplementation with vitamin D in our study did not significantly affect their serum levels.
Negative_regulation (reduce) of OPG
4) Confidence 0.25 Published 2010 Journal Nutr J Section Body Doc Link PMC2818614 Disease Relevance 0.17 Pain Relevance 0.03
The tumor releases osteoclast maturation factors or stimulates osteoblast secretion of RANKL and down-regulation of osteoprotegerin, resulting in dominant resorptive activity [9], [84], [85].
Negative_regulation (regulation) of osteoprotegerin in osteoblast associated with cancer and osteoporosis
5) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2966439 Disease Relevance 1.27 Pain Relevance 0.45
For example, it has been reported that OPG expression is limited to endothelial cells below the synovial membrane within the psoriatic joint [12]; in contrast, we did not identify reduced circulating OPG concentrations in patients with PsA or a relation between these concentrations and patterns of bone remodeling.
Negative_regulation (reduced) of OPG in joint associated with psoriasis and arthritis
6) Confidence 0.05 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945067 Disease Relevance 0.56 Pain Relevance 0.18
Additional soluble factors also influence bone remodeling; recent work has demonstrated that Dickkopf (Dkk-1), an inhibitor of Wnt signaling, inhibits osteoblast differentiation and function and promotes osteoclastogenesis through suppression of OPG [8-11].
Negative_regulation (suppression) of OPG in osteoblast associated with osteoporosis
7) Confidence 0.05 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945067 Disease Relevance 0.50 Pain Relevance 0.12
Although the major complication of an OPG is visual loss, hypothalamic involvement can lead to death.
Negative_regulation (loss) of OPG associated with death
8) Confidence 0.03 Published 2007 Journal Neurosurg Focus Section Abstract Doc Link 18004957 Disease Relevance 1.67 Pain Relevance 0.14
Furthermore, osteoprotegerin levels are markedly suppressed, further driving osteoclast formation.
Negative_regulation (suppressed) of osteoprotegerin in osteoclast
9) Confidence 0.03 Published 2006 Journal Clin. Cancer Res. Section Body Doc Link 17062712 Disease Relevance 0 Pain Relevance 0

General Comments

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