INT139482

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Context Info
Confidence 0.56
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 0.20
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkaca) nucleoplasm (Prkaca) mitochondrion (Prkaca)
Golgi apparatus (Prkaca) plasma membrane (Prkaca) nucleus (Prkaca)
Anatomy Link Frequency
SON 5
hippocampus 4
ARC 1
Prkaca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 10 99.84 Very High Very High Very High
fluoxetine 2 87.24 High High
Analgesic 6 50.00 Quite Low
electroacupuncture 6 50.00 Quite Low
Lasting pain 3 50.00 Quite Low
Pain 3 10.00 Low Low
Disease Link Frequency Relevance Heat
Stress 4 100.00 Very High Very High Very High
Pain 3 50.00 Quite Low
Cognitive Disorder 3 19.20 Low Low
Injury 3 17.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: Chronic unpredicted mild stress can affect the PKA and P-CREB expression in hippocampus of rats and fluoxetine has antagonism against it.


Regulation (affect) of Gene_expression (expression) of PKA in hippocampus
1) Confidence 0.56 Published 2006 Journal Zhong Nan Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 17062949 Disease Relevance 0 Pain Relevance 0
[Effect of chronic stress on PKA and P-CREB expression in hippocampus of rats and the antagonism of antidepressors].
Regulation ([Effect) of Gene_expression (expression) of PKA in hippocampus associated with stress and hippocampus
2) Confidence 0.41 Published 2006 Journal Zhong Nan Da Xue Xue Bao Yi Xue Ban Section Title Doc Link 17062949 Disease Relevance 0.20 Pain Relevance 0.18
IGV of PKA, ARC and SON in OVX + CCI + EA 2 w group were markedly higher than those in CCI + EA 2 w group (P<0.05), suggesting an apparent attenuation of the cumulative upregulation effect of PKA expression after learning-memory injury.
Regulation (effect) of Gene_expression (expression) of PKA in SON
3) Confidence 0.27 Published 2008 Journal Zhen Ci Yan Jiu Section Body Doc Link 18630581 Disease Relevance 0 Pain Relevance 0
The changing tendency of PKA expression in hippocampal CA1 region was similar to that of SON after repeated EA of ST36 and GB34.
Regulation (changing) of Gene_expression (expression) of PKA in SON
4) Confidence 0.27 Published 2008 Journal Zhen Ci Yan Jiu Section Body Doc Link 18630581 Disease Relevance 0 Pain Relevance 0
IGV of PKA, ARC and SON in OVX + CCI + EA 2 w group were markedly higher than those in CCI + EA 2 w group (P<0.05), suggesting an apparent attenuation of the cumulative upregulation effect of PKA expression after learning-memory injury.
Regulation (effect) of in ARC Gene_expression (expression) of PKA in SON
5) Confidence 0.09 Published 2008 Journal Zhen Ci Yan Jiu Section Body Doc Link 18630581 Disease Relevance 0 Pain Relevance 0

General Comments

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