INT139486

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Context Info
Confidence 0.27
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.10
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh) signal transducer activity (Oprm1)
Anatomy Link Frequency
brain 1
Oprm1 (Rattus norvegicus)
Crh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 2 100.00 Very High Very High Very High
addiction 1 98.92 Very High Very High Very High
Raphe 1 89.80 High High
Serotonin 1 87.76 High High
Hippocampus 1 86.84 High High
Cannabinoid 1 84.96 Quite High
Substantia nigra 1 75.88 Quite High
Ventral tegmentum 1 75.04 Quite High
Nucleus accumbens 1 70.80 Quite High
antagonist 1 44.08 Quite Low
Disease Link Frequency Relevance Heat
Drug Dependence 1 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results point to a role for the mu-opioid receptor, TH, PENK, CRF, CB1-R, and 5-HTT genes in specific brain regions in the modulation of neuroadaptative mechanisms associated to the decrease of ethanol intake induced by naltrexone.
mu-opioid receptor Positive_regulation (role) of CRF in brain associated with opioid receptor
1) Confidence 0.27 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17063152 Disease Relevance 0.10 Pain Relevance 0.42

General Comments

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