INT139493

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Context Info
Confidence 0.57
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 16.96
Pain Relevance 7.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Scly) cytoplasm (Scly)
Scly (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 984 100.00 Very High Very High Very High
depression 67 100.00 Very High Very High Very High
Fibrositis 9 99.14 Very High Very High Very High
Pain 5 93.44 High High
Inflammation 24 84.64 Quite High
alcohol 7 79.52 Quite High
Angina 1 5.80 Low Low
Demyelination 24 5.00 Very Low Very Low Very Low
intrathecal 16 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Demyelinating Disease 1008 100.00 Very High Very High Very High
Depression 68 100.00 Very High Very High Very High
Mental Disorders 73 99.20 Very High Very High Very High
Fibromyalgia 7 99.14 Very High Very High Very High
Disorder Of Lipid Metabolism 72 98.68 Very High Very High Very High
Anxiety Disorder 38 93.88 High High
Pain 3 93.44 High High
Stomach Cancer 38 91.28 High High
Disease 172 88.68 High High
Neurodegenerative Disease 16 85.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Multivariate ANOVA (SPSS General Linear Models, Unianova) was conducted for each of the two outcome measures, SCL and SWB.
Gene_expression (each) of SCL associated with depression
1) Confidence 0.57 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2936431 Disease Relevance 0.62 Pain Relevance 0.14
Marked increase of SEMG levels, and a decrease of TEMP and SCL were observed at the dominant side in the FMS Group, and a negative correlation of SEMG levels with TEMP and SCL was found.
Gene_expression (levels) of SCL associated with fibrositis
2) Confidence 0.29 Published 2006 Journal Appl Psychophysiol Biofeedback Section Abstract Doc Link 17063406 Disease Relevance 0.75 Pain Relevance 0.54
Other studies added additional data on elevated immunoglobulin expression in MScl CSF, as well as increased levels of apolipoprotein E [11], [12].
Gene_expression (expression) of MScl CSF associated with multiple sclerosis and disorder of lipid metabolism
3) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.87 Pain Relevance 0.52
Other proteins, such as serine/threonine kinase NLK and sodium leak channel non-selective protein were more abundant in PP MScl than in RR MScl, although for the latter protein the difference was small (1.18 fold increase).
Gene_expression (abundant) of PP MScl associated with multiple sclerosis
4) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.95 Pain Relevance 0.97
This particular protein was over three times less abundant in PP MScl compared to RR MScl.
Gene_expression (abundant) of PP MScl associated with multiple sclerosis
5) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.76 Pain Relevance 0.85
This particular protein was over three times less abundant in PP MScl compared to RR MScl.
Gene_expression (abundant) of RR MScl associated with multiple sclerosis
6) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.87 Pain Relevance 0.91
Other proteins, such as serine/threonine kinase NLK and sodium leak channel non-selective protein were more abundant in PP MScl than in RR MScl, although for the latter protein the difference was small (1.18 fold increase).
Gene_expression (abundant) of RR MScl associated with multiple sclerosis
7) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.96 Pain Relevance 0.98
PP MScl versus RR MScl
Gene_expression (versus) of PP MScl associated with multiple sclerosis
8) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.90 Pain Relevance 0.89
PP MScl versus RR MScl
Gene_expression (versus) of RR MScl associated with multiple sclerosis
9) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.90 Pain Relevance 0.89
Another interesting differentially abundant protein is vitamin D-binding protein, which was not detected by mass spectrometry in the PP MScl samples but was detected in the RR MScl samples.
Gene_expression (detected) of RR MScl associated with multiple sclerosis
10) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.91 Pain Relevance 0.93
DHL, KWP, JHK, SYO, IGH, JMK, SCL, HYL, HSK and HYL followed the patients and collected the data.
Gene_expression (followed) of SCL
11) Confidence 0.01 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2978206 Disease Relevance 0.47 Pain Relevance 0

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