INT139493

Context Info Confidence 0.57 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 11 Total Number 11 Disease Relevance 16.96 Pain Relevance 7.61

lyase activity (Scly) cytoplasm (Scly)

Scly (Mus musculus)

Pain Link Frequency Relevance Heat Multiple sclerosis 984 100.00 depression 67 100.00 Fibrositis 9 99.14 Pain 5 93.44 Inflammation 24 84.64 alcohol 7 79.52 Angina 1 5.80 Demyelination 24 5.00 intrathecal 16 5.00 Central nervous system 8 5.00

Disease Link Frequency Relevance Heat Demyelinating Disease 1008 100.00 Depression 68 100.00 Mental Disorders 73 99.20 Fibromyalgia 7 99.14 Disorder Of Lipid Metabolism 72 98.68 Anxiety Disorder 38 93.88 Pain 3 93.44 Stomach Cancer 38 91.28 Disease 172 88.68 Neurodegenerative Disease 16 85.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Multivariate ANOVA (SPSS General Linear Models, Unianova) was conducted for each of the two outcome measures, SCL and SWB.

Gene_expression (each) of SCL associated with depression

1) Confidence 0.57 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2936431 Disease Relevance 0.62 Pain Relevance 0.14

Marked increase of SEMG levels, and a decrease of TEMP and SCL were observed at the dominant side in the FMS Group, and a negative correlation of SEMG levels with TEMP and SCL was found.

Gene_expression (levels) of SCL associated with fibrositis

2) Confidence 0.29 Published 2006 Journal Appl Psychophysiol Biofeedback Section Abstract Doc Link 17063406 Disease Relevance 0.75 Pain Relevance 0.54

Other studies added additional data on elevated immunoglobulin expression in MScl CSF, as well as increased levels of apolipoprotein E [11], [12].

Gene_expression (expression) of MScl CSF associated with multiple sclerosis and disorder of lipid metabolism

3) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.87 Pain Relevance 0.52

Other proteins, such as serine/threonine kinase NLK and sodium leak channel non-selective protein were more abundant in PP MScl than in RR MScl, although for the latter protein the difference was small (1.18 fold increase).

Gene_expression (abundant) of PP MScl associated with multiple sclerosis

4) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.95 Pain Relevance 0.97

This particular protein was over three times less abundant in PP MScl compared to RR MScl.

Gene_expression (abundant) of PP MScl associated with multiple sclerosis

5) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.76 Pain Relevance 0.85

This particular protein was over three times less abundant in PP MScl compared to RR MScl.

Gene_expression (abundant) of RR MScl associated with multiple sclerosis

6) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.87 Pain Relevance 0.91

Other proteins, such as serine/threonine kinase NLK and sodium leak channel non-selective protein were more abundant in PP MScl than in RR MScl, although for the latter protein the difference was small (1.18 fold increase).

Gene_expression (abundant) of RR MScl associated with multiple sclerosis

7) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.96 Pain Relevance 0.98

PP MScl versus RR MScl

Gene_expression (versus) of PP MScl associated with multiple sclerosis

8) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.90 Pain Relevance 0.89

PP MScl versus RR MScl

Gene_expression (versus) of RR MScl associated with multiple sclerosis

9) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.90 Pain Relevance 0.89

Another interesting differentially abundant protein is vitamin D-binding protein, which was not detected by mass spectrometry in the PP MScl samples but was detected in the RR MScl samples.

Gene_expression (detected) of RR MScl associated with multiple sclerosis

10) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.91 Pain Relevance 0.93

DHL, KWP, JHK, SYO, IGH, JMK, SCL, HYL, HSK and HYL followed the patients and collected the data.

Gene_expression (followed) of SCL

11) Confidence 0.01 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2978206 Disease Relevance 0.47 Pain Relevance 0

General Comments

This test has worked.