INT139512

Context Info Confidence 0.37 First Reported 2006 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 0.69 Pain Relevance 0.26

plasma membrane (EDNRB) signal transducer activity (EDNRB)

Anatomy Link Frequency smooth muscle 4 EDNRB (Homo sapiens)

Pain Link Frequency Relevance Heat antagonist 5 87.08 anesthesia 2 72.88 cva 7 65.68 Catecholamine 2 14.40 ischemia 18 5.00 Calcium channel 9 5.00 Migraine 5 5.00 Inflammation 4 5.00 Multiple sclerosis 2 5.00 rheumatoid arthritis 2 5.00

Disease Link Frequency Relevance Heat Increased Venous Pressure Under Development 95 94.20 Low Tension Glaucoma 17 91.68 Eye Disease 1 82.00 Cv General 3 Under Development 5 65.68 Glaucoma 101 50.48 Disease 27 5.00 Cv Unclassified Under Development 24 5.00 Ocular Hypertension 23 5.00 Diabetes Mellitus 10 5.00 Reperfusion Injury 9 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The authors suggest this response may be due to a combination of diminished ETA receptor-mediated tone, increased ETB receptor mediated contraction, or impaired release of NO (Henry et al 2006).

Positive_regulation (increased) of Localization (release) of ETB

1) Confidence 0.37 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699797 Disease Relevance 0.69 Pain Relevance 0.03

These data suggest that, in sheep treated with clinically relevant doses of betamethasone at a gestational stage when human fetuses are routinely exposed to glucocorticoids, there is a dual effect of betamethasone on the adult sheep brachial artery, i.e. endothelial dysfunction with an impairment of endothelin-1 ETB receptor-induced release of nitric oxide and an increased contribution of the ETB receptor in smooth muscle to the contractile effects of ET-1.

Positive_regulation (increased) of Localization (release) of ETB receptor in smooth muscle

2) Confidence 0.12 Published 2006 Journal Pediatr. Res. Section Abstract Doc Link 17065564 Disease Relevance 0 Pain Relevance 0.12

These data suggest that, in sheep treated with clinically relevant doses of betamethasone at a gestational stage when human fetuses are routinely exposed to glucocorticoids, there is a dual effect of betamethasone on the adult sheep brachial artery, i.e. endothelial dysfunction with an impairment of endothelin-1 ETB receptor-induced release of nitric oxide and an increased contribution of the ETB receptor in smooth muscle to the contractile effects of ET-1.

Positive_regulation (induced) of Localization (release) of ETB receptor in smooth muscle

3) Confidence 0.11 Published 2006 Journal Pediatr. Res. Section Abstract Doc Link 17065564 Disease Relevance 0 Pain Relevance 0.12

General Comments

This test has worked.