INT139512

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.69
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (EDNRB) signal transducer activity (EDNRB)
Anatomy Link Frequency
smooth muscle 4
EDNRB (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 5 87.08 High High
anesthesia 2 72.88 Quite High
cva 7 65.68 Quite High
Catecholamine 2 14.40 Low Low
ischemia 18 5.00 Very Low Very Low Very Low
Calcium channel 9 5.00 Very Low Very Low Very Low
Migraine 5 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 95 94.20 High High
Low Tension Glaucoma 17 91.68 High High
Eye Disease 1 82.00 Quite High
Cv General 3 Under Development 5 65.68 Quite High
Glaucoma 101 50.48 Quite High
Disease 27 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 24 5.00 Very Low Very Low Very Low
Ocular Hypertension 23 5.00 Very Low Very Low Very Low
Diabetes Mellitus 10 5.00 Very Low Very Low Very Low
Reperfusion Injury 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The authors suggest this response may be due to a combination of diminished ETA receptor-mediated tone, increased ETB receptor mediated contraction, or impaired release of NO (Henry et al 2006).
Positive_regulation (increased) of Localization (release) of ETB
1) Confidence 0.37 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699797 Disease Relevance 0.69 Pain Relevance 0.03
These data suggest that, in sheep treated with clinically relevant doses of betamethasone at a gestational stage when human fetuses are routinely exposed to glucocorticoids, there is a dual effect of betamethasone on the adult sheep brachial artery, i.e. endothelial dysfunction with an impairment of endothelin-1 ETB receptor-induced release of nitric oxide and an increased contribution of the ETB receptor in smooth muscle to the contractile effects of ET-1.
Positive_regulation (increased) of Localization (release) of ETB receptor in smooth muscle
2) Confidence 0.12 Published 2006 Journal Pediatr. Res. Section Abstract Doc Link 17065564 Disease Relevance 0 Pain Relevance 0.12
These data suggest that, in sheep treated with clinically relevant doses of betamethasone at a gestational stage when human fetuses are routinely exposed to glucocorticoids, there is a dual effect of betamethasone on the adult sheep brachial artery, i.e. endothelial dysfunction with an impairment of endothelin-1 ETB receptor-induced release of nitric oxide and an increased contribution of the ETB receptor in smooth muscle to the contractile effects of ET-1.
Positive_regulation (induced) of Localization (release) of ETB receptor in smooth muscle
3) Confidence 0.11 Published 2006 Journal Pediatr. Res. Section Abstract Doc Link 17065564 Disease Relevance 0 Pain Relevance 0.12

General Comments

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