INT139513

Context Info Confidence 0.41 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0 Pain Relevance 0.62

plasma membrane (EDNRB) signal transducer activity (EDNRB)

Anatomy Link Frequency smooth muscle 4 EDNRB (Homo sapiens)

Pain Link Frequency Relevance Heat antagonist 42 88.16 agonist 22 84.88 qutenza 14 83.12 Calcitonin gene-related peptide 39 80.64 anesthesia 1 73.96 Potency 3 70.96 Neurotransmitter 4 28.28 Inflammation 2 5.00 aspirin 1 5.00 TRP channel 1 5.00

Disease Link Frequency Relevance Heat Increased Venous Pressure Under Development 3 49.76 Disease 4 29.36 Hypertension 1 6.08 Cardiovascular Disease 3 5.00 INFLAMMATION 2 5.00 Pain 1 5.00 Cv Unclassified Under Development 1 5.00 Cancer 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Binding of Rh-ET-1 (16 nM) to smooth muscle (Fig. 6D) was reduced by BQ788 (1 µM; Fig. 6E) and was prevented by presence of either ET-1 (16 nM) or of both BQ788 (1 µM) and BQ123 (1 µM)[2] indicating selective binding to ETA- and ETB-receptors.

Negative_regulation (prevented) of Localization (presence) of ETB in smooth muscle

1) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2879375 Disease Relevance 0 Pain Relevance 0.50

These data suggest that, in sheep treated with clinically relevant doses of betamethasone at a gestational stage when human fetuses are routinely exposed to glucocorticoids, there is a dual effect of betamethasone on the adult sheep brachial artery, i.e. endothelial dysfunction with an impairment of endothelin-1 ETB receptor-induced release of nitric oxide and an increased contribution of the ETB receptor in smooth muscle to the contractile effects of ET-1.

Negative_regulation (impairment) of Localization (release) of ETB receptor in smooth muscle

2) Confidence 0.11 Published 2006 Journal Pediatr. Res. Section Abstract Doc Link 17065564 Disease Relevance 0 Pain Relevance 0.12

General Comments

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