INT139514

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.73
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 4.63
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (EDNRB) signal transducer activity (EDNRB)
Anatomy Link Frequency
smooth muscle 3
liver 1
lung 1
parenchyma 1
kidney 1
EDNRB (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 4 99.92 Very High Very High Very High
antagonist 143 87.08 High High
Inflammation 17 86.76 High High
agonist 23 84.88 Quite High
qutenza 14 83.12 Quite High
Calcitonin gene-related peptide 39 80.64 Quite High
anesthesia 2 72.88 Quite High
Potency 3 70.44 Quite High
cva 23 65.68 Quite High
adenocard 6 46.36 Quite Low
Disease Link Frequency Relevance Heat
Fibrosis 4 99.92 Very High Very High Very High
Increased Venous Pressure Under Development 152 98.76 Very High Very High Very High
Pulmonary Hypertension 421 97.60 Very High Very High Very High
Low Tension Glaucoma 17 91.68 High High
Natriuresis 7 88.36 High High
INFLAMMATION 18 86.76 High High
Hypoxia 10 85.20 High High
Stress 10 84.84 Quite High
Eye Disease 1 82.00 Quite High
Congenital Anomalies 5 69.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Binding of Rh-ET-1 (16 nM) to smooth muscle (Fig. 6D) was reduced by BQ788 (1 µM; Fig. 6E) and was prevented by presence of either ET-1 (16 nM) or of both BQ788 (1 µM) and BQ123 (1 µM)[2] indicating selective binding to ETA- and ETB-receptors.
Localization (presence) of ETB in smooth muscle
1) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2879375 Disease Relevance 0 Pain Relevance 0.47
The authors suggest this response may be due to a combination of diminished ETA receptor-mediated tone, increased ETB receptor mediated contraction, or impaired release of NO (Henry et al 2006).
Localization (release) of ETB
2) Confidence 0.55 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699797 Disease Relevance 0.69 Pain Relevance 0.03
In theory, selective ETA blockade would prevent the most salient vasoconstrictive and mitogenic effects of ET-1 while maintaining ETB mediated release of NO and prostacyclin and maximal clearance of circulating ET-1 (Vatter and Seifert 2006).
Localization (release) of ETB
3) Confidence 0.40 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761178 Disease Relevance 0.56 Pain Relevance 0.08
ET-B is found in endothelial cells, as well as liver, lung, and kidney tissues.
Localization (found) of ET-B in lung
4) Confidence 0.23 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC3004515 Disease Relevance 0.83 Pain Relevance 0.15
ET-B binding in lung, liver, and kidney parenchyma is believed to be one mechanism of clearance of endothelin.
Localization (clearance) of ET-B in parenchyma
5) Confidence 0.20 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC3004515 Disease Relevance 0.90 Pain Relevance 0.24
These data suggest that, in sheep treated with clinically relevant doses of betamethasone at a gestational stage when human fetuses are routinely exposed to glucocorticoids, there is a dual effect of betamethasone on the adult sheep brachial artery, i.e. endothelial dysfunction with an impairment of endothelin-1 ETB receptor-induced release of nitric oxide and an increased contribution of the ETB receptor in smooth muscle to the contractile effects of ET-1.
Localization (release) of ETB receptor in smooth muscle
6) Confidence 0.18 Published 2006 Journal Pediatr. Res. Section Abstract Doc Link 17065564 Disease Relevance 0 Pain Relevance 0.12
These data suggest that, in sheep treated with clinically relevant doses of betamethasone at a gestational stage when human fetuses are routinely exposed to glucocorticoids, there is a dual effect of betamethasone on the adult sheep brachial artery, i.e. endothelial dysfunction with an impairment of endothelin-1 ETB receptor-induced release of nitric oxide and an increased contribution of the ETB receptor in smooth muscle to the contractile effects of ET-1.
Localization (release) of ETB receptor in smooth muscle
7) Confidence 0.17 Published 2006 Journal Pediatr. Res. Section Abstract Doc Link 17065564 Disease Relevance 0 Pain Relevance 0.12
gels were stained with ethidium bromide (EtBr) given its widespread use as an
Localization (use) of EtBr
8) Confidence 0.17 Published 2008 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2648627 Disease Relevance 0 Pain Relevance 0
ET-B is found in endothelial cells, as well as liver, lung, and kidney tissues.
Localization (found) of ET-B in kidney
9) Confidence 0.08 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC3004515 Disease Relevance 0.83 Pain Relevance 0.15
ET-B is found in endothelial cells, as well as liver, lung, and kidney tissues.
Localization (found) of ET-B in liver
10) Confidence 0.08 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC3004515 Disease Relevance 0.83 Pain Relevance 0.15

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox