INT139515

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 10.35
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (EDNRB) signal transducer activity (EDNRB)
Anatomy Link Frequency
endothelial cells 4
smooth muscle 2
blood 1
Boss 1
fibroblasts 1
EDNRB (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 4 98.00 Very High Very High Very High
Kinase C 10 96.76 Very High Very High Very High
cytokine 9 92.08 High High
antagonist 281 87.76 High High
Inflammation 28 77.56 Quite High
fibrosis 4 76.88 Quite High
anesthesia 4 70.80 Quite High
cva 20 61.60 Quite High
Calcium channel 21 53.68 Quite High
medulla 19 50.04 Quite High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 265 99.96 Very High Very High Very High
Apoptosis 12 99.52 Very High Very High Very High
Skin Cancer 29 99.20 Very High Very High Very High
Diabetes Mellitus 155 98.86 Very High Very High Very High
Pulmonary Hypertension 749 98.76 Very High Very High Very High
Cancer 25 97.84 Very High Very High Very High
Hyperplasia 12 93.72 High High
Myocardial Infarction 96 92.72 High High
Hyperglycemia 11 92.48 High High
Death 53 91.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since in the present study both ET-1 and NOS activation exhibit a similar course in 28-days diabetic rats, we speculate that NOS stimulation could be due to activation of ETB receptors via elevated ET-1 mechanisms.
Positive_regulation (activation) of ETB associated with diabetes mellitus
1) Confidence 0.67 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 0.98 Pain Relevance 0.03
In studies of porcine eyes, ET-1 increases ocular blood flow at negligible doses and reduces it at higher ones, which is thought to occur secondary to activation of ETB and ETA receptors, respectively (Yao et al 1991).
Positive_regulation (activation) of ETB in blood
2) Confidence 0.51 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699797 Disease Relevance 0.77 Pain Relevance 0
The ETB receptors are principally involved in the clearance of ET-1, particularly in the vascular beds of the lungs and kidney, and may induces vasodilation via release of NO and prostacyclin from the endothelial cells (Hirata et al 1993; Rubin et al 2005a).
Positive_regulation (induces) of ETB in kidney associated with increased venous pressure under development
3) Confidence 0.49 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994051 Disease Relevance 0.44 Pain Relevance 0.13
Endothelin-1 receptor subtype B (ETB) is expressed in smooth muscle and endothelial cells.19 Activation of endothelial ETB mediates clearance of endothelin-1 and vasodilatation by nitric oxide and prostacyclin release.16 Because of these effects ETB activation is theoretically desirable in PAH.
Positive_regulation (activation) of ETB in endothelial cells associated with pulmonary hypertension and increased venous pressure under development
4) Confidence 0.49 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2940744 Disease Relevance 1.07 Pain Relevance 0.06
ET-1 activates ETB receptors at low doses, whilst at higher doses ETA receptors are activated.
Positive_regulation (activates) of ETB
5) Confidence 0.49 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605321 Disease Relevance 0.37 Pain Relevance 0.04
It activates ETA and ETB receptors; ETA receptors are located predominantly on smooth muscle tissue of blood vessels, mediating vasoconstriction and sodium retention, whereas ETB receptors are located predominantly on endothelial cells mediating nitric oxide release, natriuresis and diuresis [61].
Positive_regulation (activates) of ETB in endothelial cells associated with diuresis, natriuresis and increased venous pressure under development
6) Confidence 0.49 Published 2010 Journal BMC Med Section Body Doc Link PMC2898678 Disease Relevance 1.43 Pain Relevance 0
Activation of ETB receptors on vascular smooth muscle causes vasoconstriction, whereas activation of ETB on endothelial cells stimulates the release of NO and prostacyclin, thus producing vasodilatory effects (Feger et al 1997).
Positive_regulation (activation) of ETB in endothelial cells associated with increased venous pressure under development
7) Confidence 0.40 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761178 Disease Relevance 0.54 Pain Relevance 0
In contrast, activation of ETB can induce apoptosis, probably via its release of NO and/or prostacyclin, although the mechanisms responsible for this effect are not well understood (Verhaar et al 1998; Niwa et al 2000).
Positive_regulation (activation) of ETB associated with apoptosis
8) Confidence 0.40 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761178 Disease Relevance 0.10 Pain Relevance 0.09
The authors suggest this response may be due to a combination of diminished ETA receptor-mediated tone, increased ETB receptor mediated contraction, or impaired release of NO (Henry et al 2006).
Positive_regulation (increased) of ETB
9) Confidence 0.37 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699797 Disease Relevance 0.67 Pain Relevance 0.03
In addition, activation of the ETB receptor, by ET-1 and ET-3, results in downstream activation of tumor-promoting events and the progression of cutaneous melanoma [16].
Positive_regulation (activation) of ETB receptor associated with cancer and skin cancer
10) Confidence 0.35 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2856553 Disease Relevance 0.97 Pain Relevance 0.04
Endothelin receptor subtype A (ETA) is predominantly found in smooth muscle and also on fibroblasts, whereas receptor subtype B (ETB) is expressed on smooth muscle and endothelial cells.19 Endothelial ETB activation mediates clearance of endothelin-1 and vasodilatation by nitric oxide and prostacyclin release.18 Because of these effects ETB activation is theoretically desirable in PAH.
Positive_regulation (activation) of ETB in fibroblasts associated with pulmonary hypertension and increased venous pressure under development
11) Confidence 0.30 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2725793 Disease Relevance 0.62 Pain Relevance 0.14
The in vitro effects of ETB activation varies with the cell type, the receptor-specific agonist used, and its concentration (Boss et al 2002).
Positive_regulation (activation) of ETB in Boss associated with agonist
12) Confidence 0.27 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761178 Disease Relevance 0.33 Pain Relevance 0.08
Activation of ETB receptors on vascular smooth muscle causes vasoconstriction, whereas activation of ETB on endothelial cells stimulates the release of NO and prostacyclin, thus producing vasodilatory effects (Feger et al 1997).
Positive_regulation (Activation) of ETB in endothelial cells associated with increased venous pressure under development
13) Confidence 0.27 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761178 Disease Relevance 0.55 Pain Relevance 0
Endothelin-1 receptor subtype B (ETB) is expressed in smooth muscle and endothelial cells.19 Activation of endothelial ETB mediates clearance of endothelin-1 and vasodilatation by nitric oxide and prostacyclin release.16 Because of these effects ETB activation is theoretically desirable in PAH.
Positive_regulation (activation) of ETB in smooth muscle associated with pulmonary hypertension and increased venous pressure under development
14) Confidence 0.17 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2940744 Disease Relevance 1.07 Pain Relevance 0.06
The ETB receptors are principally involved in the clearance of ET-1, particularly in the vascular beds of the lungs and kidney, and may induces vasodilation via release of NO and prostacyclin from the endothelial cells (Hirata et al 1993; Rubin et al 2005a).
Positive_regulation (induces) of ETB in lungs associated with increased venous pressure under development
15) Confidence 0.17 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994051 Disease Relevance 0.44 Pain Relevance 0.13
These data suggest that, in sheep treated with clinically relevant doses of betamethasone at a gestational stage when human fetuses are routinely exposed to glucocorticoids, there is a dual effect of betamethasone on the adult sheep brachial artery, i.e. endothelial dysfunction with an impairment of endothelin-1 ETB receptor-induced release of nitric oxide and an increased contribution of the ETB receptor in smooth muscle to the contractile effects of ET-1.
Positive_regulation (increased) of ETB receptor in smooth muscle
16) Confidence 0.11 Published 2006 Journal Pediatr. Res. Section Abstract Doc Link 17065564 Disease Relevance 0 Pain Relevance 0.11

General Comments

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