INT139533

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Context Info
Confidence 0.47
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 7.67
Pain Relevance 4.14

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molecular_function (Il23r) cellular_component (Il23r) biological_process (Il23r)
Anatomy Link Frequency
bowel 2
Il23r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spinal inflammation 45 100.00 Very High Very High Very High
Crohn's disease 10 100.00 Very High Very High Very High
Inflammation 8 99.56 Very High Very High Very High
psoriasis 4 98.44 Very High Very High Very High
rheumatoid arthritis 2 98.28 Very High Very High Very High
cytokine 3 96.40 Very High Very High Very High
Multiple sclerosis 15 94.80 High High
abdominal pain 2 92.44 High High
spondylitis 2 72.24 Quite High
Disease Link Frequency Relevance Heat
Low Back Pain 47 100.00 Very High Very High Very High
Disease 13 100.00 Very High Very High Very High
Autoimmune Disease 5 100.00 Very High Very High Very High
Inflammatory Bowel Disease 12 99.56 Very High Very High Very High
Systemic Lupus Erythematosus 6 99.32 Very High Very High Very High
Psoriasis 4 98.44 Very High Very High Very High
Rheumatoid Arthritis 2 98.28 Very High Very High Very High
Demyelinating Disease 15 94.80 High High
Hemorrhage 2 94.08 High High
Diarrhoea 2 92.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Replication studies confirmed IL23R associations in independent cohorts of patients with Crohn's disease or ulcerative colitis.
IL23R Binding (associations) of associated with inflammatory bowel disease, crohn's disease and disease
1) Confidence 0.47 Published 2006 Journal Science Section Abstract Doc Link 17068223 Disease Relevance 0.91 Pain Relevance 0.42
We found a highly significant association between Crohn's disease and the IL23R gene on chromosome 1p31, which encodes a subunit of the receptor for the proinflammatory cytokine interleukin-23.
IL23R Binding (association) of associated with crohn's disease, disease and cytokine
2) Confidence 0.47 Published 2006 Journal Science Section Abstract Doc Link 17068223 Disease Relevance 0.94 Pain Relevance 0.42
RESULTS: Interestingly, we observed association of two of eight IL23R genotyped SNPs.
IL23R Binding (association) of
3) Confidence 0.47 Published 2008 Journal Ann. Rheum. Dis. Section Body Doc Link 18199597 Disease Relevance 0.17 Pain Relevance 0
OBJECTIVES: Recent results have shown that the IL23R gene, coding for a subunit of the interleukin-23 receptor, is strongly associated with autoimmunity.
IL23R gene Binding (associated) of associated with autoimmune disease
4) Confidence 0.47 Published 2008 Journal Ann. Rheum. Dis. Section Abstract Doc Link 18199597 Disease Relevance 0.17 Pain Relevance 0.16
OBJECTIVE: The results of a recent genome-wide association study have shown that ERAP1 and IL23R are associated with ankylosing spondylitis (AS) in Caucasian populations from North America and the UK.
IL23R Binding (associated) of associated with spinal inflammation
5) Confidence 0.37 Published 2009 Journal Arthritis Rheum. Section Abstract Doc Link 19877036 Disease Relevance 0.27 Pain Relevance 0.35
Recent studies have shown association of the IL23R gene with inflammatory bowel disease, psoriasis and ankylosing spondylitis.
IL23R Binding (association) of in bowel associated with spinal inflammation, psoriasis and inflammation
6) Confidence 0.37 Published 2008 Journal Genes Immun. Section Abstract Doc Link 18368064 Disease Relevance 1.07 Pain Relevance 0.39
OBJECTIVE: We investigated the association between systemic lupus erythematosus (SLE) and polymorphisms of interleukin-23 receptor (IL23R) gene, which was recently found to be associated with autoimmune diseases, including Crohn's disease, rheumatoid arthritis, psoriasis and ankylosing spondylitis.
interleukin-23 receptor Binding (associated) of associated with spinal inflammation, psoriasis, autoimmune disease, crohn's disease, rheumatoid arthritis, disease and systemic lupus erythematosus
7) Confidence 0.37 Published 2010 Journal Inflamm. Res. Section Abstract Doc Link 19757086 Disease Relevance 0.76 Pain Relevance 0.24
OBJECTIVE: We investigated the association between systemic lupus erythematosus (SLE) and polymorphisms of interleukin-23 receptor (IL23R) gene, which was recently found to be associated with autoimmune diseases, including Crohn's disease, rheumatoid arthritis, psoriasis and ankylosing spondylitis.
IL23R Binding (associated) of associated with spinal inflammation, psoriasis, autoimmune disease, crohn's disease, rheumatoid arthritis, disease and systemic lupus erythematosus
8) Confidence 0.37 Published 2010 Journal Inflamm. Res. Section Abstract Doc Link 19757086 Disease Relevance 0.76 Pain Relevance 0.24
However, no association was observed between IL23R and AS (for all SNPs, P > 0.1).
IL23R Neg (no) Binding (association) of
9) Confidence 0.29 Published 2009 Journal Arthritis Rheum. Section Body Doc Link 19877036 Disease Relevance 0.08 Pain Relevance 0
The nonsynonymous SNP in IL23R, rs11209026, widely thought to be the primary AS-associated SNP in IL23R in Europeans, was found not to be polymorphic in Chinese.
IL23R Binding (associated) of
10) Confidence 0.29 Published 2009 Journal Arthritis Rheum. Section Body Doc Link 19877036 Disease Relevance 0.07 Pain Relevance 0
CONCLUSION: Our results demonstrate that genetic polymorphisms in ERAP1 are associated with AS in Han Chinese, suggesting a common pathogenic mechanism for the disease in Chinese and Caucasian populations, and that IL23R is not associated with AS in Chinese, indicating a difference in the mechanism of disease pathogenesis between Chinese and Caucasian populations.
IL23R Binding (associated) of
11) Confidence 0.29 Published 2009 Journal Arthritis Rheum. Section Body Doc Link 19877036 Disease Relevance 0.06 Pain Relevance 0
Association of IL23R and ERAP1 genes with ankylosing spondylitis in a Portuguese population.
IL23R Binding (Association) of associated with spinal inflammation
12) Confidence 0.26 Published 2009 Journal Clin. Exp. Rheumatol. Section Title Doc Link 19917163 Disease Relevance 0.59 Pain Relevance 0.51
CONCLUSION: The association of IL23R and AS that is seen in Caucasian patients with AS is not present in Korean patients with AS.


IL23R Binding (association) of
13) Confidence 0.17 Published 2009 Journal J. Rheumatol. Section Body Doc Link 19369463 Disease Relevance 0.17 Pain Relevance 0
Recently published genetic studies in psoriasis, inflammatory bowel disease, and ankylosing spondylitis identified significant associations with IL12B and IL23R polymorphisms.
IL23R Binding (associations) of in bowel associated with spinal inflammation, psoriasis and inflammation
14) Confidence 0.15 Published 2007 Journal Hum. Immunol. Section Abstract Doc Link 18082575 Disease Relevance 0.88 Pain Relevance 0.41
OBJECTIVE: IL23R polymorphisms have been shown to have a significant association with ankylosing spondylitis (AS).
IL23R Binding (association) of associated with spinal inflammation
15) Confidence 0.12 Published 2009 Journal J. Rheumatol. Section Abstract Doc Link 19369463 Disease Relevance 0.27 Pain Relevance 0.45
We also replicated previously reported associations at IL23R (rs11209026; P = 9.1 x 10(-14)) and ERAP1 (rs27434; P = 5.3 x 10(-12)).
IL23R Binding (associations) of
16) Confidence 0.09 Published 2010 Journal Nat. Genet. Section Abstract Doc Link 20062062 Disease Relevance 0.39 Pain Relevance 0.43
Association between the interleukin 23 receptor and ankylosing spondylitis is confirmed by a new UK case-control study and meta-analysis of published series.
interleukin 23 receptor Binding (Association) of associated with spinal inflammation
17) Confidence 0.03 Published 2009 Journal Rheumatology (Oxford) Section Title Doc Link 19189980 Disease Relevance 0.10 Pain Relevance 0.10

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