INT139546

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Context Info
Confidence 0.75
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.00
Pain Relevance 1.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (URI1) protein folding (URI1) nucleus (URI1)
cytoplasm (URI1)
Anatomy Link Frequency
neuron 1
URI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 6 98.08 Very High Very High Very High
dorsal root ganglion 32 96.20 Very High Very High Very High
hyperexcitability 5 95.76 Very High Very High Very High
Action potential 14 90.56 High High
Nav1.7 30 85.00 Quite High
Paroxysmal extreme pain disorder 42 84.00 Quite High
repetitive firing 2 80.36 Quite High
Nav1.1 1 74.64 Quite High
sodium channel 9 65.84 Quite High
nociceptor 4 52.00 Quite High
Disease Link Frequency Relevance Heat
Common Cold 6 100.00 Very High Very High Very High
Rhinitis 8 99.80 Very High Very High Very High
Erythermalgia 16 99.72 Very High Very High Very High
Toxicity 5 97.52 Very High Very High Very High
Ganglion Cysts 33 96.20 Very High Very High Very High
Cough 11 94.40 High High
Somatoform Disorder 42 84.00 Quite High
Respiratory Disease 1 79.36 Quite High
Epilepsy 1 75.52 Quite High
Pathologic Processes 1 52.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
URI, expressed as a geometric mean (+/-95% CI) log(10) muM of capsaicin for C2 (the lowest concentration of capsaicin in mumol/l required to induce >or=2 coughs) were: 1.8 (1.6-1.9) vs. 1.0 (0.8-1.2) vs. 0.48 (0.2-0.8), P<0.001 and for C5 (the lowest concentration of capsaicin in mumol/l required to induce >or=5 coughs) 2.9 (2.8-2.9) vs. 2.6 (2.5-2.6) vs. 2.1 (2.0-2.3), P<0.05.
Gene_expression (expressed) of URI associated with common cold, qutenza and cough
1) Confidence 0.75 Published 2006 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 17072057 Disease Relevance 1.72 Pain Relevance 0.46
CiteULike normalizes bookmarks before adding them to its database, which means it calculates whether each URI bookmarked identifies an identical publication added by another user, with an equivalent URI.
Spec (whether) Gene_expression (bookmarked) of URI
2) Confidence 0.36 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2568856 Disease Relevance 0 Pain Relevance 0
For example, inclusion complex of anti-tubercular RMP with ?
Gene_expression (tubercular) of RMP
3) Confidence 0.19 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2991688 Disease Relevance 0.27 Pain Relevance 0
However, Harty et al [13,16,17] have shown that depolarization of RMP produced by an IEM mutation (A863P) contributes to, but is not solely responsible for, the increase in DRG neuron hyperexcitability produced by that mutation.
Gene_expression (produced) of RMP in neuron associated with dorsal root ganglion, erythermalgia and hyperexcitability
4) Confidence 0.11 Published 2008 Journal Mol Pain Section Body Doc Link PMC2556659 Disease Relevance 1.01 Pain Relevance 1.03

General Comments

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