INT139556

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Context Info
Confidence 0.25
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 4.52
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrna4) transport (Chrna4) plasma membrane (Chrna4)
neurological system process (Chrna4)
Anatomy Link Frequency
forebrain 1
lung 1
heart 1
Chrna4 (Mus musculus)
Pain Link Frequency Relevance Heat
Nicotine 607 99.98 Very High Very High Very High
imagery 87 96.84 Very High Very High Very High
agonist 9 92.48 High High
antagonist 11 85.76 High High
addiction 1 84.16 Quite High
Hippocampus 15 77.40 Quite High
Inflammation 12 64.40 Quite High
IPN 1 61.24 Quite High
transdermal 8 48.08 Quite Low
Thalamus 1 26.20 Quite Low
Disease Link Frequency Relevance Heat
Hypoxia 186 99.68 Very High Very High Very High
Apoptosis 104 97.24 Very High Very High Very High
Lung Cancer 24 96.28 Very High Very High Very High
Death 42 93.92 High High
Nicotine Addiction 67 93.40 High High
Cardiovascular Disease 6 81.76 Quite High
Peripheral Arterial Disease 2 80.56 Quite High
Disease 13 79.24 Quite High
Targeted Disruption 33 69.52 Quite High
INFLAMMATION 12 64.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In situ mRNA hybridization was also performed to determine if altered mRNA transcription mediated the interdependence of alpha4 and beta2 subunit expression. alpha4-Null mutation did not affect beta2 mRNA expression, nor did beta2 genotype affect alpha4 mRNA expression.
Positive_regulation (interdependence) of alpha4
1) Confidence 0.25 Published 2006 Journal J. Comp. Neurol. Section Abstract Doc Link 17072836 Disease Relevance 0 Pain Relevance 0.10
7 nAChR-mediated functions in this forebrain-dependent trace task are engaged to a greater degree than in many of the other measures of learning and memory previously assessed in nAChR KOs, thus making eyeblink conditioning a useful paradigm for future studies investigating functional deficits resulting from nAChR loss and dysfunction.


Positive_regulation (engaged) of nAChR in forebrain
2) Confidence 0.12 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2958052 Disease Relevance 0.07 Pain Relevance 0.07
Our studies presented in this manuscript suggest that nicotine stimulation of nAChR, and essentially activation of nAChR function, does indeed contribute to the progression of lung cancers.
Positive_regulation (stimulation) of nAChR in lung associated with lung cancer and nicotine
3) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759510 Disease Relevance 0.97 Pain Relevance 0.14
7* nAChR, whereas activation of ErbB tyrosine kinases does not.


Positive_regulation (activation) of nAChR
4) Confidence 0.04 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0
Therefore, it is likely that both DF+hESC-ECs and non-transduced hESC-ECs respond to nAChR activation in a similar manner.
Positive_regulation (activation) of nAChR
5) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737633 Disease Relevance 0.24 Pain Relevance 0.24
8 M nicotine induced the phosphorylation of Akt, suggesting an effect of nAChR activation on these signaling molecules.
Positive_regulation (activation) of nAChR associated with nicotine
6) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737633 Disease Relevance 0.97 Pain Relevance 0.41
In addition to enhancing cell survival, nAChR activation also promoted significantly higher levels of angiogenesis.
Positive_regulation (activation) of nAChR
7) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737633 Disease Relevance 0.13 Pain Relevance 0.43
In addition to protein expression, quantitative PCR analysis revealed that nAChR activation during hypoxia could selectively up-regulate the angiogenic genes bFGF and VEGF-A, but not FLT1 or FLK1 expression (Figure 6F–I, Table S1).
Positive_regulation (activation) of nAChR associated with hypoxia
8) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737633 Disease Relevance 0.93 Pain Relevance 0.37
This finding concurs with our immunoblotting data by demonstrating the importance of Akt and nAChR activation for cell survival during hypoxia.


Positive_regulation (activation) of nAChR associated with hypoxia
9) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737633 Disease Relevance 0.78 Pain Relevance 0.29
Furthermore, nAChR activation led to upregulation of VEGF-A and bFGF gene expression and enhanced hESC-EC survival and neovasculature formation after delivery in ischemic heart tissue.
Positive_regulation (activation) of nAChR in heart
10) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737633 Disease Relevance 0.43 Pain Relevance 0.30

General Comments

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