INT139560

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Context Info
Confidence 0.78
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 2.33
Pain Relevance 5.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Tph2) cellular_component (Tph2) response to stress (Tph2)
Anatomy Link Frequency
neurons 3
brain 2
DRN 2
amygdala 1
Tph2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 29 99.80 Very High Very High Very High
midbrain 15 99.68 Very High Very High Very High
Raphe 24 99.16 Very High Very High Very High
fluoxetine 23 98.48 Very High Very High Very High
amygdala 6 98.28 Very High Very High Very High
depression 16 98.00 Very High Very High Very High
medulla 7 97.32 Very High Very High Very High
antidepressant 17 96.00 Very High Very High Very High
Eae 3 84.68 Quite High
Raphe magnus 1 83.76 Quite High
Disease Link Frequency Relevance Heat
Anxiety Disorder 210 99.80 Very High Very High Very High
Depression 23 98.00 Very High Very High Very High
Stress 4 97.40 Very High Very High Very High
Sprains And Strains 2 88.32 High High
Pseudorabies 1 85.80 High High
Pain 1 75.12 Quite High
Shock 1 74.04 Quite High
Neurodegenerative Disease 4 67.48 Quite High
Congenital Anomalies 2 64.00 Quite High
Obsessive-compulsive Disorder 8 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lithium modulates tryptophan hydroxylase 2 gene expression and serotonin release in primary cultures of serotonergic raphe neurons.
Gene_expression (expression) of tryptophan hydroxylase 2 in neurons associated with raphe and serotonin
1) Confidence 0.78 Published 2010 Journal Brain Res. Section Title Doc Link 19840776 Disease Relevance 0.09 Pain Relevance 0.31
Using real-time reverse transcriptase polymerase chain reaction and Western blotting, we examined the effect of lithium on tryptophan hydroxylase 2 (TPH2) expression, the rate-limiting enzyme in brain 5-HT biosynthesis.
Gene_expression (expression) of TPH2 in brain
2) Confidence 0.78 Published 2010 Journal Brain Res. Section Abstract Doc Link 19840776 Disease Relevance 0.06 Pain Relevance 0.36
Using real-time reverse transcriptase polymerase chain reaction and Western blotting, we examined the effect of lithium on tryptophan hydroxylase 2 (TPH2) expression, the rate-limiting enzyme in brain 5-HT biosynthesis.
Gene_expression (expression) of tryptophan hydroxylase 2 in brain
3) Confidence 0.78 Published 2010 Journal Brain Res. Section Abstract Doc Link 19840776 Disease Relevance 0.07 Pain Relevance 0.37
Our results suggest that lithium can modify tph2 gene expression and 5-HT release in raphe neurons, providing new insight into the serotonergic mechanisms of action of lithium.
Gene_expression (expression) of tph2 gene in neurons associated with raphe
4) Confidence 0.78 Published 2010 Journal Brain Res. Section Abstract Doc Link 19840776 Disease Relevance 0.05 Pain Relevance 0.34
Using real-time reverse transcription-polymerase chain reaction (RT-PCR) and semi-quantitative RT-PCR techniques, we have examined the effects of fluoxetine administration with drinking water (7.5 mg/kg/day) for 2, 4 and 8 weeks on TPH2 mRNA expression in the midbrain part of the dorsal raphe nucleus (DRN) and in the brainstem containing the rest of the raphe complex.
Gene_expression (expression) of TPH2 mRNA in DRN associated with medulla, midbrain, raphe and fluoxetine
5) Confidence 0.78 Published 2007 Journal Neuroscience Section Abstract Doc Link 17950541 Disease Relevance 0 Pain Relevance 0.86
The results of the present study suggest that TPH2 gene expression in the midbrain part of the DRN is implicated in depression and stress response, as well as in the antidepressant fluoxetine action.
Gene_expression (expression) of TPH2 in DRN associated with stress, antidepressant, depression, midbrain and fluoxetine
6) Confidence 0.78 Published 2007 Journal Neuroscience Section Abstract Doc Link 17950541 Disease Relevance 0.20 Pain Relevance 1.10
Using immunofluorescent methods we determined whether coinfected neurons expressed TPH2.
Spec (whether) Gene_expression (expressed) of TPH2 in neurons
7) Confidence 0.74 Published 2006 Journal J. Comp. Neurol. Section Abstract Doc Link 17072838 Disease Relevance 0.33 Pain Relevance 0.46
Fluoxetine treatment for 4 and 8, but not for 2 weeks, abolished these swim-induced changes in TPH2 and 5-HTT mRNAs levels in the midbrain and 5-HIAA content in the amygdala.
Gene_expression (levels) of TPH2 in amygdala associated with midbrain, amygdala and fluoxetine
8) Confidence 0.67 Published 2007 Journal Neuroscience Section Abstract Doc Link 17950541 Disease Relevance 0 Pain Relevance 1.12
In the same study, the authors reported that short-term lithium treatment (8 days) resulted in a 45% decrease in tryptophan hydroxylase 2 (TPH2) expression and a 31% reduction in TPH2 protein levels, completely compensated after long-term treatment (14 days).
Gene_expression (expression) of TPH2
9) Confidence 0.31 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.43 Pain Relevance 0.26
In analysis of the SNPs, rs4570625 and rs456946 of TPH2, they found a significant preferential transmission of haplotype G-C to OCD.
Gene_expression (analysis) of TPH2 associated with anxiety disorder
10) Confidence 0.17 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687723 Disease Relevance 1.09 Pain Relevance 0.27

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