INT139562

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Context Info
Confidence 0.68
First Reported 2004
Last Reported 2011
Negated 1
Speculated 5
Reported most in Body
Documents 10
Total Number 21
Disease Relevance 6.14
Pain Relevance 2.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL18) extracellular space (IL18) extracellular region (IL18)
cell-cell signaling (IL18) cytoplasm (IL18)
Anatomy Link Frequency
macrophage 1
plaque 1
endometrium 1
PBMC 1
IL18 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 5 100.00 Very High Very High Very High
cytokine 246 98.16 Very High Very High Very High
Dismenorea 16 97.88 Very High Very High Very High
rheumatoid arthritis 186 97.56 Very High Very High Very High
Inflammation 163 91.68 High High
psoriasis 55 77.52 Quite High
cva 17 65.72 Quite High
alcohol 14 62.56 Quite High
depression 3 59.60 Quite High
Angina 5 53.60 Quite High
Disease Link Frequency Relevance Heat
Psoriasis 68 98.80 Very High Very High Very High
Atherosclerotic Plaque 6 98.52 Very High Very High Very High
Dysmenorrhea 16 97.88 Very High Very High Very High
Rheumatoid Arthritis 186 97.56 Very High Very High Very High
Necrosis 38 96.04 Very High Very High Very High
Cancer 37 95.68 Very High Very High Very High
Syndrome 5 93.56 High High
Disease 68 92.00 High High
INFLAMMATION 173 91.68 High High
Death 34 91.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Eutopic endometrial interleukin-18 system mRNA and protein expression at the level of endometrial-myometrial interface in adenomyosis patients.
Transcription (expression) of interleukin-18 associated with dismenorea
1) Confidence 0.68 Published 2010 Journal Fertil. Steril. Section Title Doc Link 19394601 Disease Relevance 0.10 Pain Relevance 0.19
Quantitative competitive PCR demonstrated that endometrial IL-18R mRNA and the ratio of IL-18BP to IL-18 were significantly increased in adenomyosis patients in comparison to the control group.
Transcription (ratio) of IL-18
2) Confidence 0.66 Published 2010 Journal Fertil. Steril. Section Body Doc Link 19394601 Disease Relevance 0.06 Pain Relevance 0
OBJECTIVE: To investigate the eutopic endometrial interleukin-18 (IL-18) system including interleukin-18 (IL-18), IL-18 receptor (IL-18R), and IL-18 binding protein (IL-18BP), mRNA, and protein expression in patients with adenomyosis.
Spec (investigate) Transcription (system) of interleukin-18 associated with dismenorea
3) Confidence 0.66 Published 2010 Journal Fertil. Steril. Section Abstract Doc Link 19394601 Disease Relevance 0.17 Pain Relevance 0.17
OBJECTIVE: To investigate the eutopic endometrial interleukin-18 (IL-18) system including interleukin-18 (IL-18), IL-18 receptor (IL-18R), and IL-18 binding protein (IL-18BP), mRNA, and protein expression in patients with adenomyosis.
Spec (investigate) Transcription (system) of IL-18 associated with dismenorea
4) Confidence 0.66 Published 2010 Journal Fertil. Steril. Section Abstract Doc Link 19394601 Disease Relevance 0.17 Pain Relevance 0.17
OBJECTIVE: To investigate the eutopic endometrial interleukin-18 (IL-18) system including interleukin-18 (IL-18), IL-18 receptor (IL-18R), and IL-18 binding protein (IL-18BP), mRNA, and protein expression in patients with adenomyosis.
Spec (investigate) Transcription (system) of IL-18 associated with dismenorea
5) Confidence 0.66 Published 2010 Journal Fertil. Steril. Section Abstract Doc Link 19394601 Disease Relevance 0.17 Pain Relevance 0.17
OBJECTIVE: To investigate the eutopic endometrial interleukin-18 (IL-18) system including interleukin-18 (IL-18), IL-18 receptor (IL-18R), and IL-18 binding protein (IL-18BP), mRNA, and protein expression in patients with adenomyosis.
Spec (investigate) Transcription (system) of IL-18 associated with dismenorea
6) Confidence 0.66 Published 2010 Journal Fertil. Steril. Section Abstract Doc Link 19394601 Disease Relevance 0.17 Pain Relevance 0.17
RESULT(S): IL-18 system mRNA and protein expression was demonstrated in the eutopic endometrium of both adenomyosis and control women.
Transcription (expression) of IL-18 in endometrium
7) Confidence 0.66 Published 2010 Journal Fertil. Steril. Section Body Doc Link 19394601 Disease Relevance 0.07 Pain Relevance 0
OBJECTIVE: To investigate the eutopic endometrial interleukin-18 (IL-18) system including interleukin-18 (IL-18), IL-18 receptor (IL-18R), and IL-18 binding protein (IL-18BP), mRNA, and protein expression in patients with adenomyosis.
Spec (investigate) Transcription (system) of interleukin-18 associated with dismenorea
8) Confidence 0.66 Published 2010 Journal Fertil. Steril. Section Abstract Doc Link 19394601 Disease Relevance 0.17 Pain Relevance 0.17
As we previously reported that high IL-18/TWEAK endometrial mRNA expression correlated with a significant increase of uNK cells recruitment, we investigated the role of these two cytokines on uNK cells cytotoxicity.
Transcription (expression) of IL-18 associated with cytokine
9) Confidence 0.64 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0 Pain Relevance 0.10
We recently reported that TWEAK and IL-18 mRNA expression were correlated in patients with implantation failures [14].
Transcription (expression) of IL-18
10) Confidence 0.64 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0.60 Pain Relevance 0.13
We retrospectively selected endometrial samples with a high IL-18 mRNA expression (over 6.17) and low (below 4.1) or high TWEAK (over 6.86) mRNA expression to compare their NKp46 and TGF-?
Transcription (expression) of IL-18
11) Confidence 0.64 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0 Pain Relevance 0
NKp46 experiments: Physiological ranges of IL-18 and TWEAK mRNA expression have been previously established in control fertile women [28].
Transcription (expression) of IL-18
12) Confidence 0.64 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0 Pain Relevance 0.06
NKp46 protein expression was also detailed by immunohistochemistry in selected patients with high basic mRNA level of IL-18 and either low or high mRNA level of TWEAK.
Transcription (level) of IL-18
13) Confidence 0.62 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3017546 Disease Relevance 0.31 Pain Relevance 0.08
We compared the presence of the uNK cytotoxic receptor, NKp46, in patients with an IL-18 over-expression (if compared to the one observed in fertile patients) and either a low or high mRNA TWEAK expression.
Transcription (expression) of IL-18
14) Confidence 0.62 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0 Pain Relevance 0.21
IL-18, initially described as an IFN-?
Transcription (described) of IL-18
15) Confidence 0.56 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.38 Pain Relevance 0.35
The mRNA expression of IL-18 in PBMC and the response of PBMC to ethanol and LPS was similar in CP patients and controls.
Transcription (expression) of IL-18 in PBMC
16) Confidence 0.55 Published 2006 Journal World J. Gastroenterol. Section Body Doc Link 17072982 Disease Relevance 0 Pain Relevance 0
8 patients were included to document NKp46 immunostaining: all patients had a high IL-18 mRNA expression and either a low (4 patients) or a high (4 patients) TWEAK expression. 22 other patients were included for the microhistoculture experiment.
Transcription (expression) of IL-18
17) Confidence 0.48 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0.23 Pain Relevance 0.07
Significantly higher levels of IL-18 mRNA were found in symptomatic (unstable) plaque than in asymptomatic (stable) plaque, suggesting IL-18 destabilizes atherosclerotic plaque leading to ischemic syndromes [65,66].
Transcription (levels) of IL-18 in plaque associated with atherosclerotic plaque and syndrome
18) Confidence 0.25 Published 2008 Journal Crit Care Section Body Doc Link PMC2481437 Disease Relevance 2.31 Pain Relevance 0.42
The concentration of PGE2, IL-10 and IL-18 was determined in culture medium of confluent cells incubated for their last 48 hours in Ham's F12/DMEM containing 1% ITS.
Transcription (concentration) of IL-18
19) Confidence 0.18 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0 Pain Relevance 0
AP-1 = activator protein-1; CRP = C-reactive protein; GM-CSF = granulocyte macrophage colony-stimulating factor; IFN = interferon; IL = interleukin; IL-1RA = interleukin-1 receptor antagonist; LPS = lipopolysaccharide; M?
Transcription (antagonist) of interleukin-1 in macrophage associated with antagonist
20) Confidence 0.10 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246244 Disease Relevance 0.91 Pain Relevance 0.17

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