INT139579

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Context Info
Confidence 0.69
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.44
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
poly 2
Trpm8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 1 99.84 Very High Very High Very High
dorsal root ganglion 20 81.52 Quite High
Kinase C 23 80.16 Quite High
bradykinin 1 78.64 Quite High
TRP channel 1 68.88 Quite High
qutenza 18 63.80 Quite High
imagery 6 57.40 Quite High
burning pain 1 55.72 Quite High
trigeminal ganglion 4 28.92 Quite Low
adenocard 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 1 99.84 Very High Very High Very High
Ganglion Cysts 25 81.52 Quite High
Nociception 17 77.48 Quite High
Pain 1 55.72 Quite High
Decapitation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, intracellular dialysis with anti-PIP(2) antibody or with the PIP(2) scavenger, poly L-lysine, enhanced the ethanol-induced inhibition of TRPM8.
Positive_regulation (enhanced) of Negative_regulation (inhibition) of TRPM8 in poly
1) Confidence 0.69 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17074062 Disease Relevance 0 Pain Relevance 0.10
Desensitization of TRPM8 channels could also be induced by inflammatory mediators that activate PLC to deplete PIP2 [20].
Positive_regulation (induced) of Negative_regulation (Desensitization) of TRPM8 associated with inflammatory mediators
2) Confidence 0.44 Published 2010 Journal Mol Pain Section Body Doc Link PMC2936373 Disease Relevance 0.44 Pain Relevance 0.35

General Comments

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