INT1396

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Context Info
Confidence 0.48
First Reported 1977
Last Reported 2010
Negated 11
Speculated 15
Reported most in Abstract
Documents 355
Total Number 370
Disease Relevance 22.79
Pain Relevance 269.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk)
Anatomy Link Frequency
brain 51
striatum 14
spinal cord 8
neurons 7
cerebellum 5
Penk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 1953 100.00 Very High Very High Very High
opiate 336 100.00 Very High Very High Very High
narcan 316 100.00 Very High Very High Very High
Morphine 281 100.00 Very High Very High Very High
Opioid 193 100.00 Very High Very High Very High
opioid receptor 190 100.00 Very High Very High Very High
substance P 115 100.00 Very High Very High Very High
antagonist 95 100.00 Very High Very High Very High
agonist 95 100.00 Very High Very High Very High
Dynorphin 85 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 69 99.92 Very High Very High Very High
Ganglion Cysts 22 99.88 Very High Very High Very High
Depression 12 99.78 Very High Very High Very High
Bordatella Infection 8 99.72 Very High Very High Very High
Stress 17 99.52 Very High Very High Very High
Pain 39 99.30 Very High Very High Very High
Pheochromocytoma 2 99.20 Very High Very High Very High
Aids-related Complex 6 98.96 Very High Very High Very High
Convulsion 28 98.92 Very High Very High Very High
Gallstones 8 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings provide a morphological substrate for enkephalin interactions with parasympathetic functions and with primary visceral inputs to the sacral cord.
enkephalin Binding (interactions) of in visceral associated with enkephalin
1) Confidence 0.48 Published 1985 Journal Brain Res. Section Abstract Doc Link 4005542 Disease Relevance 0.09 Pain Relevance 0.58
This suggests that SP/Enk-8 interaction occurs at the axon terminals of the substantia gelatinosa neurons.
Enk-8 Binding (interaction) of in substantia gelatinosa associated with substantia gelatinosa neuron
2) Confidence 0.48 Published 1988 Journal Brain Res. Section Abstract Doc Link 2456830 Disease Relevance 0 Pain Relevance 0.65
ENK was also associated with small clear vesicles and large dense-core vesicles within certain axon terminals in the preoptic nucleus.
ENK Spec (clear) Binding (associated) of in vesicles associated with enkephalin
3) Confidence 0.48 Published 1981 Journal Neurosci. Lett. Section Abstract Doc Link 6173823 Disease Relevance 0 Pain Relevance 0.63
The marked decrease in binding of 3H-Leu-Enkephalin observed in the presence of high concentration of sodium ions indicates that these two pentapeptides have the same properties as morphinomimetic analgesics.
3H-Leu-Enkephalin Binding (binding) of associated with analgesic and enkephalin
4) Confidence 0.48 Published 1977 Journal C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat. Section Abstract Doc Link 402232 Disease Relevance 0 Pain Relevance 0.67
Reaferon was found to inhibit the binding of 3H-D-ala2, D-leu5-enkephalin, and Ki value calculated was equal to 8.5 +/- 2.6 U.10(-3)/ml.
D-leu5-enkephalin Binding (binding) of associated with enkephalin
5) Confidence 0.48 Published 1988 Journal Biull Eksp Biol Med Section Abstract Doc Link 2844322 Disease Relevance 0 Pain Relevance 0.53
In vitro and in vivo inhibition by lithium of enkephalin binding to opiate receptors in rat brain.
enkephalin Binding (binding) of in brain associated with opiate and enkephalin
6) Confidence 0.48 Published 1982 Journal Neuropharmacology Section Title Doc Link 6289161 Disease Relevance 0 Pain Relevance 1.06
In vivo, long term ingestion of lithium (3 weeks), during which the rats were maintained at a serum lithium level of approximately 1 mM, also inhibited enkephalin binding to rat neuronal membranes (P2-fractions) through a reduction of the number of opiate receptor binding sites, whereas the affinity was unchanged.
enkephalin Binding (binding) of in neuronal associated with opiate and enkephalin
7) Confidence 0.48 Published 1982 Journal Neuropharmacology Section Abstract Doc Link 6289161 Disease Relevance 0 Pain Relevance 0.94
Interaction of enkephalin and caerulein on guinea pig small intestine.
enkephalin Binding (Interaction) of in small intestine associated with narcan and enkephalin
8) Confidence 0.47 Published 1983 Journal Am. J. Physiol. Section Title Doc Link 6849395 Disease Relevance 0 Pain Relevance 0.73
Interaction of enkephalin peptides with anionic model membranes.
enkephalin Binding (Interaction) of associated with analgesic and enkephalin
9) Confidence 0.47 Published 2002 Journal Biochim. Biophys. Acta Section Title Doc Link 11750263 Disease Relevance 0 Pain Relevance 0.60
Both the membrane-bound and the solubilized receptors showed weak binding of enkephalin and mu-specific drugs, suggesting that they are predominantly of the kappa-type.
enkephalin Binding (binding) of associated with enkephalin
10) Confidence 0.47 Published 1984 Journal J. Neurochem. Section Abstract Doc Link 6088699 Disease Relevance 0 Pain Relevance 0.21
No high molecular weight met-enkephalin IR could be detected in the platelet extracts, even after trypsin hydrolysis, using two antisera which are able to recognize some of the putative met-enkephalin precursors present in the adrenal gland or striatum.
met-enkephalin Binding (recognize) of in adrenal gland associated with enkephalin
11) Confidence 0.47 Published 1982 Journal Life Sci. Section Abstract Doc Link 7098767 Disease Relevance 0.07 Pain Relevance 0.84
From the data obtained it is concluded that apomorphine, like naloxone, is a "pure" antagonist but it has much less affinity for enkephalin and opiate binding sites.
enkephalin Binding (affinity) of associated with antagonist, narcan, opiate and enkephalin
12) Confidence 0.47 Published 1980 Journal Biull Eksp Biol Med Section Abstract Doc Link 6256025 Disease Relevance 0 Pain Relevance 0.80
Two of the antibodies recognize the COOH-terminus part of the Met-enkephalin, and do not cross-react with other known peptides.
Met-enkephalin Binding (recognize) of associated with enkephalin
13) Confidence 0.47 Published 1983 Journal J. Neuroimmunol. Section Abstract Doc Link 6822659 Disease Relevance 0 Pain Relevance 0.31
In contrast, specific binding of the delta ligand [3H]D-Ala2,D-Leu5-enkephalin was virtually totally eliminated as a result of formaldehyde perfusion.
enkephalin Binding (binding) of associated with enkephalin
14) Confidence 0.47 Published 1985 Journal Peptides Section Abstract Doc Link 2995943 Disease Relevance 0 Pain Relevance 0.75
Moreover, both morphine and naloxone were equally active in competing for [3H]Met-Enk binding in all 3 brain regions during the first month after birth, whereas methionine-enkephalin was only about 30-50% as active as morphine n competing for [3H]naloxone binding in that period.
Enk Binding (binding) of in brain associated with narcan, enkephalin and morphine
15) Confidence 0.47 Published 1982 Journal Brain Res. Section Abstract Doc Link 6280806 Disease Relevance 0 Pain Relevance 1.14
Computer analysis of the displacement [3H]leucine enkephalin binding by various concentrations of morphine has demonstrated that an allosteric model, not a two-site model, best describes the observed data.
enkephalin Binding (binding) of associated with enkephalin and morphine
16) Confidence 0.47 Published 1982 Journal Mol. Pharmacol. Section Abstract Doc Link 7110115 Disease Relevance 0 Pain Relevance 1.55
In contrast, Scatchard analysis of the binding of [3H]leucine enkephalin in the absence and presence of 10, 50, and 100 nM morphine demonstrated that these concentrations of morphine decreased the number of binding sites by 23%, 32%, and 42%, respectively, with no change in the KD.
enkephalin Binding (binding) of associated with enkephalin and morphine
17) Confidence 0.47 Published 1982 Journal Mol. Pharmacol. Section Abstract Doc Link 7110115 Disease Relevance 0 Pain Relevance 1.10
Clozapine has been found to inhibit the binding of [3H]met-enkephalin to synaptosome-enriched fractions prepared from rat whole brain and hippocampus in a Tris-buffered media without added ions.
enkephalin Binding (binding) of in hippocampus associated with hippocampus and enkephalin
18) Confidence 0.47 Published 1981 Journal Neurochem. Res. Section Abstract Doc Link 7266749 Disease Relevance 0 Pain Relevance 0.23
Specific enkephalin binding was found in a rat pheochromocytoma cell line, PC12 (subclone h), when cultured in the presence of nerve growth factor (NGF; 50 ng/ml).
enkephalin Binding (binding) of in nerve associated with nerve growth factor, enkephalin and pheochromocytoma
19) Confidence 0.47 Published 1982 Journal J. Biol. Chem. Section Abstract Doc Link 6286607 Disease Relevance 0.10 Pain Relevance 0.47
However, addition of ethanol directly in the incubation medium decreased the binding of 3H-DADL enkephalin and increased the binding of 3H-dihydromorphine to brain membranes from both control and ethanol treated rats.
enkephalin Binding (binding) of in brain associated with enkephalin
20) Confidence 0.47 Published 1983 Journal Life Sci. Section Abstract Doc Link 6350782 Disease Relevance 0 Pain Relevance 0.59

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