INT139613

Context Info Confidence 0.47 First Reported 2006 Last Reported 2010 Negated 1 Speculated 4 Reported most in Body Documents 16 Total Number 21 Disease Relevance 5.52 Pain Relevance 8.46

Anatomy Link Frequency superior 1 spinal cord 1 body 1 pr (Mus musculus)

Pain Link Frequency Relevance Heat Oxycodone 178 100.00 narcan 142 100.00 Migraine 132 100.00 Pain 125 100.00 Paracetamol 38 100.00 headache 42 99.08 Sumatriptan 57 98.88 Triptan 246 95.84 Analgesic 53 82.36 cINOD 9 81.20

Disease Link Frequency Relevance Heat Pain 173 100.00 Migraine Disorders 141 100.00 Diarrhoea 13 99.22 Headache 39 99.08 Meningioma 127 98.38 Amnesia 6 93.88 Disease 52 91.32 Arrhythmias 2 Under Development 16 87.00 Stress 6 85.68 Cancer 46 79.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Age, disease duration, and body mass index (BMI) were significantly associated with the PR interval, and male gender, disease duration, and the Bath Ankylosing Spondylitis Metrology Index (BASMI) with the QRS interval.

PR Binding (associated) of in body

1) Confidence 0.47 Published 2010 Journal Scand. J. Rheumatol. Section Body Doc Link 20132069 Disease Relevance 0.29 Pain Relevance 0

The possible conformation of PR interacting with IA displayed the nature of the interaction between PR and IA; hydrogen bonds (hbs) mainly contribute to this interaction.

PR Binding (interaction) of associated with paracetamol

2) Confidence 0.47 Published 2010 Journal Appl. Biochem. Biotechnol. Section Abstract Doc Link 18769881 Disease Relevance 0 Pain Relevance 0.71

The optimal solvents for porogen and eluant were determined by the strength of hbs interaction between PR and the solvents, which were calculated employing density functional theory.

PR Binding (interaction) of associated with paracetamol

3) Confidence 0.47 Published 2010 Journal Appl. Biochem. Biotechnol. Section Abstract Doc Link 18769881 Disease Relevance 0 Pain Relevance 0.68

In multivariate analyses, disease duration remained independently associated with both the PR and the QRS intervals.

PR Binding (associated) of

4) Confidence 0.36 Published 2010 Journal Scand. J. Rheumatol. Section Body Doc Link 20132069 Disease Relevance 0.26 Pain Relevance 0

UV spectra analysis confirmed the occurrence of the hbs interaction between PR and IA at the polymerization stage.

PR Binding (interaction) of associated with paracetamol

5) Confidence 0.35 Published 2010 Journal Appl. Biochem. Biotechnol. Section Abstract Doc Link 18769881 Disease Relevance 0 Pain Relevance 0.70

Base on our previous work, the promising monomer, itaconic acid (IA), was computationally selected rapidly from the virtual library using the interaction energy (DeltaE) between a paracetamol (PR) molecule and four monomer molecules as a measure of their interaction.

PR Binding (interaction) of associated with paracetamol

6) Confidence 0.32 Published 2010 Journal Appl. Biochem. Biotechnol. Section Abstract Doc Link 18769881 Disease Relevance 0 Pain Relevance 0.70

An interaction effect between gender and age was not observed over development for PR interval, QRS interval, or QTc interval (Figures 2B-D).

PR Binding (interval) of

7) Confidence 0.27 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2936334 Disease Relevance 0 Pain Relevance 0

However, we find precisely maintained PR intervals with no sex difference present through PND28.

PR Neg (no) Binding (intervals) of

8) Confidence 0.27 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2936334 Disease Relevance 0.21 Pain Relevance 0

Females showed an elongation of PR interval compared to males at this time point (24.4 ± 0.8 ms versus 22.9 ± 1.6 ms, P ?

PR Binding (interval) of

9) Confidence 0.27 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2936334 Disease Relevance 0 Pain Relevance 0

Intravenous morphine [patient-controlled analgesia (PCA)/continuous infusion] was associated with Pr in 68% of subjects over a wide dose range (9.4-63.2 mug.kg(-1).hr(-1)).

Pr Binding (associated) of

10) Confidence 0.27 Published 2006 Journal Can J Anaesth Section Body Doc Link 17079637 Disease Relevance 0.07 Pain Relevance 0

The proposed method was successfully applied for the determination of PR and its related substances in laboratory-prepared mixtures of different proportions.

PR Spec (determination) Binding (determination) of associated with paracetamol

11) Confidence 0.16 Published 2009 Journal J AOAC Int Section Abstract Doc Link 20166578 Disease Relevance 0 Pain Relevance 0.49

Although bone metastasis and spinal cord compression were frequently recognized indications for PR, only 50% of other assessed indications for PR were correctly identified.

PR Binding (recognized) of in spinal cord

12) Confidence 0.11 Published 2008 Journal J Cancer Educ Section Body Doc Link 18709586 Disease Relevance 0.08 Pain Relevance 0

A higher RU486 dose was used in experiments with both K14CrePR and K5Cre*PR as lower doses appeared relatively ineffective in inducing Cre activity in pilot experiments (not shown).

PR Spec (appeared) Binding (experiments) of

13) Confidence 0.08 Published 2010 Journal International Journal of Biological Sciences Section Body Doc Link PMC2815352 Disease Relevance 0 Pain Relevance 0

Secondly, our definition of PR was different from the one generally used in clinical trials.

PR Binding (definition) of

14) Confidence 0.07 Published 2007 Journal International Journal of Clinical Practice Section Body Doc Link PMC1974799 Disease Relevance 0.60 Pain Relevance 0.73

PR intervals are not prolonged in ?

PR Binding (intervals) of

15) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597774 Disease Relevance 0.21 Pain Relevance 0

The primary study outcome measures were the times, in minutes, to migraine PR and PF, recorded by stopwatch.

PR Binding (migraine) of associated with migraine

16) Confidence 0.06 Published 2007 Journal International Journal of Clinical Practice Section Body Doc Link PMC1974799 Disease Relevance 0.77 Pain Relevance 0.71

A large randomised clinical trial (n = 1268) reports significant superior treatment efficacy of pain relief (PR) at 2 h and pain freedom (PF) at 2 h after dosing for rizatriptan 10 mg over sumatriptan 100 mg (9).

PR Binding (dosing) of in superior associated with sumatriptan and pain

17) Confidence 0.06 Published 2007 Journal International Journal of Clinical Practice Section Body Doc Link PMC1974799 Disease Relevance 1.07 Pain Relevance 2.16

We examined the conventional clinicopathologic factors including the six different biological factors (ER, PR, p53, c-erbB2, bcl-2, and Ki-67) by immunohistochemistry and evaluated their association with clinical outcomes.

PR Spec (examined) Binding (association) of

18) Confidence 0.04 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2217558 Disease Relevance 0.57 Pain Relevance 0.04

Importantly, the incidence of diarrhoea was low, and SOWS sum scores were not exacerbated with oxycodone PR/naloxone PR.

PR Binding (exacerbated) of associated with oxycodone, diarrhoea and narcan

19) Confidence 0.02 Published 2010 Journal International Journal of Clinical Practice Section Body Doc Link PMC2948431 Disease Relevance 0.46 Pain Relevance 0.77

Importantly, the incidence of diarrhoea was low, and SOWS sum scores were not exacerbated with oxycodone PR/naloxone PR.

PR Binding (exacerbated) of associated with oxycodone, diarrhoea and narcan

20) Confidence 0.02 Published 2010 Journal International Journal of Clinical Practice Section Body Doc Link PMC2948431 Disease Relevance 0.46 Pain Relevance 0.77

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