INT139614

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Context Info
Confidence 0.78
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 2.29
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Usp14) cytoplasmic membrane-bounded vesicle (Usp14) plasma membrane (Usp14)
cytoplasm (Usp14)
Anatomy Link Frequency
neuronal 3
Usp14 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 4 59.68 Quite High
Disease Link Frequency Relevance Heat
Ataxia 12 99.76 Very High Very High Very High
Targeted Disruption 8 99.08 Very High Very High Very High
Frailty 4 95.28 Very High Very High Very High
Movement Disorders 4 78.16 Quite High
Neuropathic Pain 4 69.44 Quite High
Disease 4 68.48 Quite High
Muscle Disease 4 66.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Biochemical analysis showed that the ubiquitin hydrolyase activity of this form of Usp14 is dependent on the presence of proteasomes, and neuronal expression of full-length Usp14 was able to restore the levels of monomeric ubiquitin in the brains of axJ mice.
Gene_expression (expression) of Usp14 in neuronal
1) Confidence 0.78 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 17079671 Disease Relevance 0.71 Pain Relevance 0.06
Transgenic rescue of the axJ mice with neuronal-specific expression of Usp14 demonstrated that the full-length form of Usp14 was sufficient to restore viability and motor system function to the axJ mice.
Gene_expression (expression) of Usp14 in neuronal associated with targeted disruption
2) Confidence 0.78 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 17079671 Disease Relevance 0.52 Pain Relevance 0
Analysis of Usp14 gene products demonstrated that Usp14 undergoes alternative pre-mRNA splicing to produce a full-length form of Usp14 that is capable of binding proteasomes and a form that contains a deletion in the Ubl domain.
Gene_expression (products) of Usp14
3) Confidence 0.68 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 17079671 Disease Relevance 0.49 Pain Relevance 0
Transgenic rescue of ataxia mice with neuronal-specific expression of ubiquitin-specific protease 14.
Gene_expression (expression) of protease 14 in neuronal associated with targeted disruption and ataxia
4) Confidence 0.53 Published 2006 Journal J. Neurosci. Section Title Doc Link 17079671 Disease Relevance 0.56 Pain Relevance 0

General Comments

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