INT139646

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.89
Pain Relevance 3.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin2b) plasma membrane (Grin2b) embryo development (Grin2b)
Anatomy Link Frequency
ACC 2
Grin2b (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 134 100.00 Very High Very High Very High
Anterior cingulate cortex 99 99.90 Very High Very High Very High
Inflammation 13 98.88 Very High Very High Very High
depression 5 98.08 Very High Very High Very High
antagonist 36 96.80 Very High Very High Very High
Glutamate 11 96.64 Very High Very High Very High
Lasting pain 45 94.96 High High
allodynia 8 93.12 High High
Neuropathic pain 21 89.36 High High
Analgesic 3 84.60 Quite High
Disease Link Frequency Relevance Heat
Injury 28 99.56 Very High Very High Very High
Targeted Disruption 19 99.10 Very High Very High Very High
INFLAMMATION 13 98.88 Very High Very High Very High
Depression 5 98.08 Very High Very High Very High
Amputation 1 95.42 Very High Very High Very High
Pain 62 94.96 High High
Nervous System Injury 25 93.52 High High
Neuropathic Pain 35 93.12 High High
Anxiety Disorder 43 80.08 Quite High
Hypersensitivity 1 78.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a recent study we found that after persistent inflammation (the Complete Freund's Adjuvant (CFA) animal model for chronic inflammation), the expression of NMDA NR2B receptors in the ACC was increased over a long-period of time, thereby increasing the NR2B component in NMDA receptor mediated EPSCs [17] (see Figure 3A, B).
Positive_regulation (increased) of Positive_regulation (increasing) of NR2B associated with inflammation, nmda receptor and anterior cingulate cortex
1) Confidence 0.42 Published 2009 Journal Mol Brain Section Body Doc Link PMC2644299 Disease Relevance 1.10 Pain Relevance 1.17
In primary striatal cultures, NT-3 treatment induced an enhancement in NR2A, but not NR2B, protein levels.
Positive_regulation (induced) of Positive_regulation (enhancement) of NR2B
2) Confidence 0.41 Published 2007 Journal Neuroscience Section Abstract Doc Link 17081696 Disease Relevance 0.06 Pain Relevance 0.24
Studies using AC1 knockout mice also demonstrated that AC1 activity is critical for NR2B upregulation after the injury.
Positive_regulation (critical) of Positive_regulation (upregulation) of NR2B associated with targeted disruption and injury
3) Confidence 0.37 Published 2009 Journal Mol Brain Section Body Doc Link PMC2644299 Disease Relevance 0.88 Pain Relevance 0.65
Moreover, there are long-term changes in synaptic plasticity and transmitter release in the ACC in chronic pain conditions: amputation causes long-term facilitation of local stimulation-induced ACC synaptic responses and specific loss of long-term synaptic depression [13,14]; peripheral inflammation of the hind paw with complete Freund's adjuvant in adult mice causes the upregulation of the postsynaptic NMDA receptor NR2B subunit [15].
Positive_regulation (causes) of Positive_regulation (upregulation) of NMDA receptor NR2B subunit in ACC associated with inflammation, depression, nmda receptor, lasting pain, amputation and anterior cingulate cortex
4) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2807858 Disease Relevance 1.86 Pain Relevance 1.68

General Comments

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