INT139648

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Context Info
Confidence 0.66
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.73
Pain Relevance 2.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ntf3) cytoplasmic membrane-bounded vesicle (Ntf3)
Anatomy Link Frequency
brain 1
parallel fiber 1
neurites 1
interneurons 1
Ntf3 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 31 100.00 Very High Very High Very High
GABAergic 4 99.84 Very High Very High Very High
Pain 32 98.92 Very High Very High Very High
dorsal root ganglion 55 98.50 Very High Very High Very High
gABA 8 95.84 Very High Very High Very High
Cancer pain 23 90.56 High High
Catecholamine 1 90.28 High High
Neurotransmitter 3 89.08 High High
Inflammation 55 87.92 High High
dopamine receptor 1 86.80 High High
Disease Link Frequency Relevance Heat
Disease 109 99.34 Very High Very High Very High
Targeted Disruption 17 99.08 Very High Very High Very High
Pain 32 98.92 Very High Very High Very High
Ganglion Cysts 58 98.50 Very High Very High Very High
Hereditary Sensory And Autonomic Neuropathies 2 97.44 Very High Very High Very High
Neuropathy 4 96.80 Very High Very High Very High
Neurodegenerative Disease 33 91.12 High High
Bone Cancer 14 90.96 High High
INFLAMMATION 73 87.92 High High
Nociception 15 87.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, intrastriatal grafting of NT-3 secreting-cells in adult wild type mice produced a down-regulation of NR2A subunit.
Localization (secreting) of NT-3
1) Confidence 0.66 Published 2007 Journal Neuroscience Section Abstract Doc Link 17081696 Disease Relevance 0.06 Pain Relevance 0.21
In addition, some of the factors with pro-neurogenic effects (such as NT-3 and Shh) can be secreted by GABAergic interneurons [62].
Localization (secreted) of NT-3 in interneurons associated with gabaergic
2) Confidence 0.53 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1849968 Disease Relevance 0.14 Pain Relevance 0.33
Prior studies showed that DRG explants from Runx3-knockout mouse embryos extended short neurites in the presence of NT3, a ligand for TrkC, but not in the presence of NGF, a ligand for TrkA [16].
Localization (presence) of NT3 in neurites associated with targeted disruption and dorsal root ganglion
3) Confidence 0.43 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.87 Pain Relevance 0.34
Many studies have shown that peripheral NGF can drive pain and have suggested that NGF and perhaps peripherally released BDNF and NT-3 may play a role in modulating pain [14,15].
Localization (released) of NT-3 associated with pain and nerve growth factor
4) Confidence 0.29 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004846 Disease Relevance 1.33 Pain Relevance 0.90
First, our data call for a re-examination of previously described TrkAII CIPA mutants regarding their NT3 signaling capability.
Localization (capability) of NT3
5) Confidence 0.26 Published 2010 Journal Exp. Neurol. Section Abstract Doc Link 20188729 Disease Relevance 0.55 Pain Relevance 0.27
On the other hand, CAPS2 is associated with secretory vesicles containing the neurotrophins BDNF and NT-3 in the parallel fiber terminals of cerebellar granule cells, and is involved in the release of BDNF and NT-3 [6].
Localization (release) of NT-3 in parallel fiber
6) Confidence 0.09 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1853102 Disease Relevance 0.18 Pain Relevance 0.09
Some evidence suggests that microglial cells can perform neuroprotective functions in PD, at least in the short term, by secreting trophic factors such as nerve growth factor, neurotrophin-3 and brain-derived neurotrophic factors (BDNFs) [23, 24].
Localization (secreting) of neurotrophin-3 in brain associated with nerve growth factor and disease
7) Confidence 0.07 Published 2011 Journal Parkinson's Disease Section Body Doc Link PMC3018622 Disease Relevance 0.61 Pain Relevance 0.08

General Comments

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