INT139648

Context Info Confidence 0.66 First Reported 2007 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 7 Total Number 7 Disease Relevance 3.73 Pain Relevance 2.22

extracellular region (Ntf3) cytoplasmic membrane-bounded vesicle (Ntf3)

Anatomy Link Frequency brain 1 parallel fiber 1 neurites 1 interneurons 1 Ntf3 (Mus musculus)

Pain Link Frequency Relevance Heat Nerve growth factor 31 100.00 GABAergic 4 99.84 Pain 32 98.92 dorsal root ganglion 55 98.50 gABA 8 95.84 Cancer pain 23 90.56 Catecholamine 1 90.28 Neurotransmitter 3 89.08 Inflammation 55 87.92 dopamine receptor 1 86.80

Disease Link Frequency Relevance Heat Disease 109 99.34 Targeted Disruption 17 99.08 Pain 32 98.92 Ganglion Cysts 58 98.50 Hereditary Sensory And Autonomic Neuropathies 2 97.44 Neuropathy 4 96.80 Neurodegenerative Disease 33 91.12 Bone Cancer 14 90.96 INFLAMMATION 73 87.92 Nociception 15 87.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, intrastriatal grafting of NT-3 secreting-cells in adult wild type mice produced a down-regulation of NR2A subunit.

Localization (secreting) of NT-3

1) Confidence 0.66 Published 2007 Journal Neuroscience Section Abstract Doc Link 17081696 Disease Relevance 0.06 Pain Relevance 0.21

In addition, some of the factors with pro-neurogenic effects (such as NT-3 and Shh) can be secreted by GABAergic interneurons [62].

Localization (secreted) of NT-3 in interneurons associated with gabaergic

2) Confidence 0.53 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1849968 Disease Relevance 0.14 Pain Relevance 0.33

Prior studies showed that DRG explants from Runx3-knockout mouse embryos extended short neurites in the presence of NT3, a ligand for TrkC, but not in the presence of NGF, a ligand for TrkA [16].

Localization (presence) of NT3 in neurites associated with targeted disruption and dorsal root ganglion

3) Confidence 0.43 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.87 Pain Relevance 0.34

Many studies have shown that peripheral NGF can drive pain and have suggested that NGF and perhaps peripherally released BDNF and NT-3 may play a role in modulating pain [14,15].

Localization (released) of NT-3 associated with pain and nerve growth factor

4) Confidence 0.29 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004846 Disease Relevance 1.33 Pain Relevance 0.90

First, our data call for a re-examination of previously described TrkAII CIPA mutants regarding their NT3 signaling capability.

Localization (capability) of NT3

5) Confidence 0.26 Published 2010 Journal Exp. Neurol. Section Abstract Doc Link 20188729 Disease Relevance 0.55 Pain Relevance 0.27

On the other hand, CAPS2 is associated with secretory vesicles containing the neurotrophins BDNF and NT-3 in the parallel fiber terminals of cerebellar granule cells, and is involved in the release of BDNF and NT-3 [6].

Localization (release) of NT-3 in parallel fiber

6) Confidence 0.09 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1853102 Disease Relevance 0.18 Pain Relevance 0.09

Some evidence suggests that microglial cells can perform neuroprotective functions in PD, at least in the short term, by secreting trophic factors such as nerve growth factor, neurotrophin-3 and brain-derived neurotrophic factors (BDNFs) [23, 24].

Localization (secreting) of neurotrophin-3 in brain associated with nerve growth factor and disease

7) Confidence 0.07 Published 2011 Journal Parkinson's Disease Section Body Doc Link PMC3018622 Disease Relevance 0.61 Pain Relevance 0.08

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