INT139649

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.63
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin2a) plasma membrane (Grin2a) locomotion (Grin2a)
Grin2a (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 3 100.00 Very High Very High Very High
antagonist 1 92.72 High High
Glutamate receptor 2 92.24 High High
tetrodotoxin 1 90.88 High High
Calcium channel 1 89.76 High High
projection neuron 2 83.80 Quite High
Enkephalin 1 82.04 Quite High
cerebral cortex 3 75.60 Quite High
Dopamine 1 74.04 Quite High
agonist 1 62.00 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 5 97.68 Very High Very High Very High
Neurodegenerative Disease 1 75.00 Quite High
Injury 1 72.16 Quite High
Death 1 50.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The deficit of endogenous NT-3 induced a decrease in NR1 and NR2A subunits at postnatal day (P) 0 and P3 mice respectively, whereas an upregulation was observed in 12 week old NT-3 +/- mice.
Positive_regulation (induced) of Negative_regulation (decrease) of NR2A
1) Confidence 0.44 Published 2007 Journal Neuroscience Section Abstract Doc Link 17081696 Disease Relevance 0.07 Pain Relevance 0.26
Moreover, inhibition of the NMDA receptor subunit NR2A or NR2B induced a differential short-term versus delayed increase in the apoptosis rate, respectively.
Positive_regulation (induced) of Negative_regulation (inhibition) of NMDA receptor subunit NR2A associated with nmda receptor and apoptosis
2) Confidence 0.16 Published 2008 Journal Cereb. Cortex Section Abstract Doc Link 17965127 Disease Relevance 0.56 Pain Relevance 0.39

General Comments

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