INT13966

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Context Info
Confidence 0.49
First Reported 1987
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 0.75
Pain Relevance 3.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca, Sst) extracellular region (Calca, Sst) aging (Calca)
nucleus (Calca) intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
blood 2
stomach 2
dorsal horn 2
Calca (Rattus norvegicus)
Sst (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 51 100.00 Very High Very High Very High
Somatostatin 40 100.00 Very High Very High Very High
spinal dorsal horn 5 100.00 Very High Very High Very High
Neuropeptide 5 100.00 Very High Very High Very High
qutenza 19 97.00 Very High Very High Very High
antagonist 6 96.04 Very High Very High Very High
intrathecal 3 92.16 High High
substance P 8 91.84 High High
Inflammation 3 76.32 Quite High
Neurotransmitter 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Nociception 8 100.00 Very High Very High Very High
INFLAMMATION 3 76.32 Quite High
Hyperalgesia 1 69.92 Quite High
Pressure And Volume Under Development 1 62.20 Quite High
Ganglion Cysts 4 5.00 Very Low Very Low Very Low
Ulcers 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Dyspepsia 2 5.00 Very Low Very Low Very Low
Loss Of Sense Of Smell 2 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that CGRP in the stomach plays a pivotal role in protection against gastric mucosal damage by indomethacin, possibly through an increase in gastric blood flow and somatostatin secretion.
CGRP Spec (possibly) Positive_regulation (increase) of Localization (secretion) of somatostatin in blood associated with somatostatin and calcitonin gene-related peptide
1) Confidence 0.49 Published 1993 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 7904285 Disease Relevance 0 Pain Relevance 1.10
Furthermore, our data suggest that CGRP facilitates processing of thermal nociception in the spinal dorsal horn, maybe through increasing the release of SST.
CGRP Positive_regulation (increasing) of Localization (release) of SST in dorsal horn associated with nociception, spinal dorsal horn, somatostatin and calcitonin gene-related peptide
2) Confidence 0.45 Published 1993 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 8392482 Disease Relevance 0.75 Pain Relevance 1.06
Calcitonin gene-related peptide (CGRP) is present in the stomach, and exogenous CGRP stimulates gastric somatostatin release.
CGRP Positive_regulation (stimulates) of Localization (release) of somatostatin in stomach associated with somatostatin and calcitonin gene-related peptide
3) Confidence 0.42 Published 1991 Journal Am. J. Physiol. Section Abstract Doc Link 1683166 Disease Relevance 0 Pain Relevance 0.78
Calcitonin gene-related peptide stimulates rat gastric somatostatin release in vitro.
Calcitonin gene-related peptide Positive_regulation (stimulates) of Localization (release) of somatostatin associated with somatostatin and calcitonin gene-related peptide
4) Confidence 0.36 Published 1987 Journal Life Sci. Section Title Doc Link 2880273 Disease Relevance 0 Pain Relevance 0.52
RESULTS: Capsaicin, like exogenous CGRP, stimulated antral somatostatin release and inhibited both gastrin release and acetylcholine discharge.
CGRP Positive_regulation (stimulated) of Localization (release) of somatostatin
5) Confidence 0.25 Published 1993 Journal Gastroenterology Section Body Doc Link 8093880 Disease Relevance 0 Pain Relevance 0
CGRP increases somatostatin release, indirectly decreasing gastrin and acid secretion (Fig. 1A).
CGRP Positive_regulation (increases) of Localization (release) of somatostatin associated with somatostatin and calcitonin gene-related peptide
6) Confidence 0.05 Published 2010 Journal Curr Gastroenterol Rep Section Body Doc Link PMC2974196 Disease Relevance 0 Pain Relevance 0.45

General Comments

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