INT139660

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Context Info
Confidence 0.70
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 7.12
Pain Relevance 3.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCL18) extracellular space (CCL18) extracellular region (CCL18)
cell-cell signaling (CCL18)
Anatomy Link Frequency
blood 2
macrophages 1
sputum 1
brain 1
CCL18 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 283 100.00 Very High Very High Very High
Inflammation 235 100.00 Very High Very High Very High
cytokine 82 100.00 Very High Very High Very High
rheumatoid arthritis 294 99.96 Very High Very High Very High
dexamethasone 43 94.12 High High
aspirin 20 93.76 High High
agonist 7 76.04 Quite High
fibrosis 11 74.08 Quite High
Inflammatory response 15 56.56 Quite High
Snapping jaw 5 50.00 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 267 100.00 Very High Very High Very High
Rheumatoid Arthritis 294 99.96 Very High Very High Very High
Eczema 124 99.64 Very High Very High Very High
Asthma 68 98.90 Very High Very High Very High
Disease 133 98.38 Very High Very High Very High
Infection 14 97.72 Very High Very High Very High
Polyps 52 96.84 Very High Very High Very High
Sarcoidosis 40 96.40 Very High Very High Very High
Rhinitis 248 94.92 High High
Ocular Hypertension 7 91.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
provides an early signal for CCL18 transcription.
Transcription (transcription) of CCL18
1) Confidence 0.70 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.09 Pain Relevance 0.17
In addition, data are presented to show that the production of CCL18 by PMN is differentially regulated at the levels of mRNA expression and protein synthesis.
Transcription (expression) of CCL18
2) Confidence 0.70 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.08 Pain Relevance 0.17
As shown in Figure 2a, mRNA expression for two selected chemokines, CCL18 and CXCL10, was readily detectable in SF PMN but remained undetectable in peripheral blood PMN from the healthy donor.
Transcription (expression) of CCL18 in blood associated with chemokine
3) Confidence 0.70 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.39 Pain Relevance 0.28
However, another study found no differences in CCL18 mRNA expression between patients and controls, yet in that study total BAL fluid cells and not sorted macrophages were studied [30].
Transcription (expression) of CCL18 in macrophages
4) Confidence 0.61 Published 2010 Journal Respir Res Section Body Doc Link PMC2939603 Disease Relevance 0.36 Pain Relevance 0.16
Both aCRSwNP and AD showed increased transcription of CCL18 (PARC), CCL22 (MDC), and CXCL13.
Transcription (transcription) of PARC associated with eczema
5) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2897889 Disease Relevance 1.17 Pain Relevance 0.23
In agreement with the exon array data, CCL13, CCL18, EMR3, and IL1RL1 transcription was increased while CRISP3 transcription was decreased in inflamed mucosa and polyp tissue from aCRSwNP subjects.
Transcription (transcription) of CCL18 associated with polyps
6) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2897889 Disease Relevance 0.55 Pain Relevance 0.04
Both aCRSwNP and AD showed increased transcription of CCL18 (PARC), CCL22 (MDC), and CXCL13.
Transcription (transcription) of CCL18 associated with eczema
7) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2897889 Disease Relevance 1.17 Pain Relevance 0.23
We also recently reported increased CCL18 protein levels in induced sputum from asthmatic subjects [17], which is consistent with the increased CCL18 transcription observed here in aCRSwNP.
Transcription (transcription) of CCL18 in sputum associated with asthma
8) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2897889 Disease Relevance 0.70 Pain Relevance 0.05
However, no mRNA expression was observed for CCL18 and CXCL10 in PMN infected with A. phagocytophilum.


Transcription (expression) of CCL18
9) Confidence 0.52 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.63 Pain Relevance 0.49
Results summarized in Figure 1 show a highly upregulated expression of CCL3 and CCL18 mRNAs, a downregulation of CCL21 mRNA (Figure 1a) and an upregulation of CXCL8 and CXCL10 mRNAs (Figure 1b) in SF PMN from each patient in comparison with blood PMN from healthy donors.
Transcription (expression) of CCL18 in blood
10) Confidence 0.52 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.22 Pain Relevance 0.11
In RA, expression of mRNA encoding CCL18 was observed in synovial tissue and it coincided with CCL18 accumulation in SF [19,20].
Transcription (expression) of CCL18 associated with rheumatoid arthritis
11) Confidence 0.52 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.34 Pain Relevance 0.56
Although the glucocorticoid action in inflammatory diseases is not fully understood, it is well documented that glucocorticoids inhibit the transcription of the majority of inflammatory cytokines and chemokines involved in the inflammatory process, including eotaxin, GM-CSF, IL-1ß, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8, IL-11, MCP-1, MIP-1, MIP-3, MIP-4, MIP-1?
Transcription (transcription) of MIP-4 associated with chemokine, inflammation, disease and cytokine
12) Confidence 0.03 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790480 Disease Relevance 1.31 Pain Relevance 0.56
Furthermore, the expression levels of Ang, brain-derived neurotrophic factor (BDNF), FGF-4, FGF-9, IGFBP-2, IL-8, MIP-1beta, OPG, pulmonary and activation-regulated protein (PARC), TGF-beta2, TIMP-2 and VEGF were significantly associated with the presence of JE; among these, nine cytokines (Ang, BDNF, FGF-4, FGF-9, IGFBP-2, MIP-1beta, PARC, TGF-beta2 and TIMP-2) were hitherto not described in TMD.
Neg (not) Transcription (described) of PARC in brain
13) Confidence 0.02 Published 2006 Journal Dentomaxillofac Radiol Section Body Doc Link 17082335 Disease Relevance 0.11 Pain Relevance 0

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