INT139664

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Context Info
Confidence 0.76
First Reported 2006
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 83
Total Number 93
Disease Relevance 37.05
Pain Relevance 21.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCL18) extracellular space (CCL18) extracellular region (CCL18)
cell-cell signaling (CCL18)
Anatomy Link Frequency
monocytes 7
macrophages 6
fibroblasts 6
joints 4
brain 3
CCL18 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 2841 100.00 Very High Very High Very High
fibrosis 144 100.00 Very High Very High Very High
Angina 22 100.00 Very High Very High Very High
antagonist 6 100.00 Very High Very High Very High
rheumatoid arthritis 3505 99.84 Very High Very High Very High
Inflammation 1088 99.32 Very High Very High Very High
cytokine 551 98.66 Very High Very High Very High
Arthritis 111 97.88 Very High Very High Very High
Inflammatory mediators 147 93.20 High High
Central nervous system 10 60.88 Quite High
Disease Link Frequency Relevance Heat
Fibrosis 88 100.00 Very High Very High Very High
Cv General 3 Under Development 22 100.00 Very High Very High Very High
Rheumatoid Arthritis 3509 99.84 Very High Very High Very High
Sarcoidosis 414 99.56 Very High Very High Very High
INFLAMMATION 1322 99.32 Very High Very High Very High
Necrosis 136 99.24 Very High Very High Very High
Wound Healing 6 99.24 Very High Very High Very High
Cancer 134 98.88 Very High Very High Very High
Pulmonary Fibrosis 62 98.78 Very High Very High Very High
Syndrome 190 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CCL18 regulates collagen production by lung fibroblasts and is abundantly produced by alveolar macrophages in patients with IPF [8,30,31].
Gene_expression (produced) of CCL18 in fibroblasts
1) Confidence 0.76 Published 2010 Journal Respir Res Section Body Doc Link PMC2907324 Disease Relevance 0.88 Pain Relevance 0.09
This study investigates the production of CCL18 in polymorphonuclear neutrophils (PMN), the predominant cell type recruited into synovial fluid (SF).
Spec (investigates) Gene_expression (production) of CCL18 in synovial fluid
2) Confidence 0.75 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2212580 Disease Relevance 0.44 Pain Relevance 0.34
CCL18 was originally described to be constitutively expressed in lung and lymphoid tissue [32].
Gene_expression (expressed) of CCL18 in lymphoid tissue
3) Confidence 0.75 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.08 Pain Relevance 0.17
Selected cell culture experiments were performed with PMN preparations depleted of eosinophils with anti-CD16 antibodies by means of magnetic-activated cell sorting (Miltenyi Biotec, Bergisch Gladbach, Germany) to exclude the possibility that contaminating eosinophils accounted for CCL18 production.
Gene_expression (production) of CCL18 in eosinophils
4) Confidence 0.75 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.06 Pain Relevance 0.03
In this context, CCL18 production was synergistically enhanced when PMN were stimulated with IL-10 in combination with vitamin D3.
Gene_expression (production) of CCL18
5) Confidence 0.75 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.30 Pain Relevance 0.15
Microarray analysis was performed to compare CCL18 mRNA expression in SF PMN from patients with RA with expression levels of other chemokines.
Gene_expression (expression) of CCL18 mRNA associated with chemokine and rheumatoid arthritis
6) Confidence 0.75 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.41 Pain Relevance 0.41
T helper cell type 2-related cytokines, including IL-4, IL-10 and IL-13, were found to induce or enhance CCL18 expression, whereas the T helper type 1-derived interferon-?
Gene_expression (expression) of CCL18 associated with cytokine
7) Confidence 0.75 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.12 Pain Relevance 0.18
induced CCL18 mRNA expression in the absence of protein synthesis.
Gene_expression (expression) of CCL18 mRNA
8) Confidence 0.75 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.28 Pain Relevance 0.14
Notably, no significant levels of CCL18 mRNA were detectable in blood PMN form RA patients (n = 9; Figure 2b), suggesting that CCL18 gene expression in SF PMN occurs as a result of the recruitment of PMN into the inflammatory milieu of the joint.


Gene_expression (detectable) of CCL18 mRNA in blood associated with inflammation and rheumatoid arthritis
9) Confidence 0.75 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.54 Pain Relevance 0.46
Another speculative explanation for the regulation of CCL18 synthesis in PMN might involve microRNAs [37].
Gene_expression (synthesis) of CCL18
10) Confidence 0.75 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.06 Pain Relevance 0.07
suppressed CCL18 mRNA expression [17].
Gene_expression (expression) of CCL18 mRNA
11) Confidence 0.75 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.13 Pain Relevance 0.18
as a potent inducer of CCL18 mRNA expression.
Gene_expression (expression) of CCL18 mRNA
12) Confidence 0.75 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.34 Pain Relevance 0.17
Notably, no significant levels of CCL18 mRNA were detectable in blood PMN form RA patients (n = 9; Figure 2b), suggesting that CCL18 gene expression in SF PMN occurs as a result of the recruitment of PMN into the inflammatory milieu of the joint.


Gene_expression (expression) of CCL18 gene in blood associated with inflammation and rheumatoid arthritis
13) Confidence 0.75 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.49 Pain Relevance 0.44
Induction of CCL18 protein synthesis in SF PMN
Gene_expression (synthesis) of CCL18 protein
14) Confidence 0.75 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.42 Pain Relevance 0.45
Hence it is reasonable to conclude that CCL18 production by PMN requires two independent signals, one for mRNA expression, provided by TNF-?
Gene_expression (production) of CCL18
15) Confidence 0.75 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.09 Pain Relevance 0.12
In DC cultures, differential regulation of CCL18 mRNA and protein expression has been attributed to changes in maturation [34,35].
Gene_expression (expression) of CCL18 mRNA
16) Confidence 0.75 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.08 Pain Relevance 0.12
Differences observed in CCL18 mRNA expression levels in SF PMN between individual RA patients did not relate to the actual therapeutic treatment (p = 0.2612, none versus conventional therapy; p = 0.3798, none versus anti-TNF therapy) as determined by quantitative RT-PCR (data not shown).
Gene_expression (expression) of CCL18 mRNA associated with rheumatoid arthritis
17) Confidence 0.75 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.47 Pain Relevance 0.38
In addition, data are presented to show that the production of CCL18 by PMN is differentially regulated at the levels of mRNA expression and protein synthesis.
Gene_expression (production) of CCL18
18) Confidence 0.75 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.08 Pain Relevance 0.17
In addition, quantitative RT-PCR revealed changes in CCL18 expression in SF PMN from RA patients (n = 9; Figure 2b) similar to those observed with microarray analysis.
Gene_expression (expression) of CCL18 associated with rheumatoid arthritis
19) Confidence 0.75 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.45 Pain Relevance 0.31
It is shown here that CCL18 mRNA expression is induced in PMN by TNF-?
Gene_expression (expression) of CCL18 mRNA
20) Confidence 0.75 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.13 Pain Relevance 0.17

General Comments

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