INT139679

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Context Info
Confidence 0.55
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 18
Disease Relevance 10.57
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ighg2b)
Anatomy Link Frequency
poly 4
B cells 3
Ighg2b (Mus musculus)
Pain Link Frequency Relevance Heat
Crohn's disease 50 98.44 Very High Very High Very High
Inflammation 160 96.40 Very High Very High Very High
chemokine 18 86.84 High High
cytokine 131 80.36 Quite High
Neuritis 2 75.00 Quite High
Potency 2 71.28 Quite High
agonist 98 70.00 Quite High
Demyelination 1 68.92 Quite High
Multiple sclerosis 5 55.52 Quite High
Buprenorphine 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 87 99.98 Very High Very High Very High
Immunization 417 99.76 Very High Very High Very High
Inflammatory Bowel Disease 38 99.52 Very High Very High Very High
Infection 150 98.60 Very High Very High Very High
Disease 106 98.44 Very High Very High Very High
Influenza Virus Infection 316 97.12 Very High Very High Very High
INFLAMMATION 141 96.40 Very High Very High Very High
Pneumonia 22 94.48 High High
Viral Infection 31 88.84 High High
Paratuberculosis 40 86.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, the OSP-induced Abs were predominantly directed against OSP22-46; these Abs were mostly of IgG1 isotype, but high levels of IgG2a and IgG2b and significant levels of IgE were also observed.
Positive_regulation (levels) of IgG2b
1) Confidence 0.55 Published 2006 Journal J. Immunol. Section Abstract Doc Link 17082656 Disease Relevance 0.70 Pain Relevance 0.24
Although these results do not formally eliminate a role for MZ B cells in the poly(I:C)-induced IgG2c response, they illustrate that MZ B cells do not make a significant contribution to this response.
Neg (not) Positive_regulation (induced) of IgG2c in B cells
2) Confidence 0.43 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0.30 Pain Relevance 0
Although poly(I:C) was found to increase total IgG2c serum levels on day 7, this increase was fully accounted for by the increase in NP-specific IgG2c at the same time point (Fig. 1 A).
Positive_regulation (increase) of IgG2c in poly
3) Confidence 0.43 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0.28 Pain Relevance 0
However, this was excluded as the frequency of splenic NP-specific IgG2c ASCs generated upon immunization with NP-Ficoll + poly(I:C) was the same regardless of MZ B cell depletion (Fig. 3 E).
Positive_regulation (generated) of IgG2c in B cell associated with immunization
4) Confidence 0.43 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0.29 Pain Relevance 0
The combined reduction observed in the double-deficient mice implicates both TLR3 and MDA5 in the recognition of poly(I:C) and subsequent induction of a class-switched IgG2c B cell response.
Positive_regulation (sequent i) of IgG2c in poly
5) Confidence 0.43 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0 Pain Relevance 0
It remained possible that MZ B cells relocated outside the spleen but were still responsive to poly(I:C) and able to generate NP-specific IgG2c from this extrasplenic site.
Positive_regulation (generate) of IgG2c in B cells
6) Confidence 0.43 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0.30 Pain Relevance 0
Our results demonstrate a minor role for TLR3 signaling in optimal induction of IgG2c by poly(I:C), supporting previous studies showing that TLR signaling is largely unnecessary for efficient antibody responses (Gavin et al., 2006).
Positive_regulation (induction) of IgG2c in poly
7) Confidence 0.43 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0.06 Pain Relevance 0.06
We further show that during the TI-2 antibody response, poly(I:C) promotes a persistence of elevated levels of antigen-specific IgG2c serum antibody, which are similar to those previously shown for TD antibody responses (Le Bon et al., 2001).
Positive_regulation (elevated) of IgG2c in poly
8) Confidence 0.37 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0.09 Pain Relevance 0
were found to mount significantly higher levels of NP-specific IgG2c than NP-Ficoll alone (Fig. 5 B).
Positive_regulation (levels) of IgG2c
9) Confidence 0.37 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0.28 Pain Relevance 0.15
Interestingly, increased IgG2a and IgG2b are responsible for the enhanced antibody levels in the 0.3 µg HA group as compared to those in the 0.1 µg HA group (Fig. 3A).
Positive_regulation (increased) of IgG2b
10) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2646145 Disease Relevance 0.71 Pain Relevance 0
Anti-HA IgG2b titres were also increased but only in CpG ODN treated mice [103].
Positive_regulation (increased) of IgG2b
11) Confidence 0.24 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 1.11 Pain Relevance 0.04
As previously reported (34,35), i.m. immunization with subunit vaccine induced high IgG1 responses but little IgG2a and IgG2b, indicating an immune response biased toward a Th2-type response.
Positive_regulation (induced) of IgG2b associated with immunization
12) Confidence 0.23 Published 2010 Journal AAPS J Section Body Doc Link PMC2844513 Disease Relevance 1.17 Pain Relevance 0
The Ninoa strain induced IgM and IgG2a in the early acute phase and IgG1, IgG2b, IgG3, and IgA after 30 days post-infection.
Positive_regulation (induced) of IgG2b associated with sprains and strains and infection
13) Confidence 0.14 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2852613 Disease Relevance 0.90 Pain Relevance 0.15
IgG subtype profiling (Fig. 5) showed that i.n. immunization with subunit vaccine alone induced low IgG1, IgG2a, and IgG2b responses.
Positive_regulation (induced) of IgG2b associated with immunization
14) Confidence 0.10 Published 2010 Journal AAPS J Section Body Doc Link PMC2844513 Disease Relevance 1.16 Pain Relevance 0
In confirmation with others [16,17], we show an increase in Mycobacteria-specific IgG1 and IgG2 Abs in sera from patients with active CD or UC.
Positive_regulation (increase) of IgG2 associated with crohn's disease
15) Confidence 0.01 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 1.43 Pain Relevance 0.28
While total IgG1, IgG2, IgG3, and IgG4 subclass Abs were significantly higher in the sera of IBD patients compared to healthy donors (data not shown), the profile of the IgG humoral response in IBD patients also revealed increases in Mycobacteria-specific IgG1 and IgG2 Abs (Figure 1).
Positive_regulation (increases) of IgG2 associated with inflammatory bowel disease
16) Confidence 0.01 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.86 Pain Relevance 0.09
Several sensitization models using OVA or house dust mite (Der f) in presence of DEP revealed also increased antigen-specific IgG1 and IgG2 levels, besides increased antigen-specific IgE [81-88].
Positive_regulation (increased) of IgG2
17) Confidence 0.01 Published 2010 Journal Respir Res Section Body Doc Link PMC2831838 Disease Relevance 0.47 Pain Relevance 0.05
Several sensitization models using OVA or house dust mite (Der f) in presence of DEP revealed also increased antigen-specific IgG1 and IgG2 levels, besides increased antigen-specific IgE [81-88].
Positive_regulation (increased) of IgG2
18) Confidence 0.01 Published 2010 Journal Respir Res Section Body Doc Link PMC2831838 Disease Relevance 0.47 Pain Relevance 0.05

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