INT139706

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.03
First Reported 2007
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 2.61
Pain Relevance 4.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnf) extracellular space (Tnf) extracellular region (Tnf)
plasma membrane (Tnf) intracellular (Tnf) extracellular matrix organization (Tnf)
Anatomy Link Frequency
spinal 2
nerve 1
Tnf (Rattus norvegicus)
Ltp (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 40 100.00 Very High Very High Very High
c fibre 20 99.84 Very High Very High Very High
Neuropathic pain 8 99.44 Very High Very High Very High
Pain 4 85.36 High High
spinal dorsal horn 8 83.76 Quite High
Hippocampus 4 72.88 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 8 99.44 Very High Very High Very High
Nervous System Injury 12 99.40 Very High Very High Very High
Pain 4 85.36 High High
Cancer 8 75.00 Quite High
Necrosis 8 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NF-kappa B (NF-kappaB) inhibitor (PDTC) also blocked LTP induced by TNF-alpha.
TNF-alpha Positive_regulation (induced) of LTP associated with long-term potentiation
1) Confidence 0.03 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17084420 Disease Relevance 0.58 Pain Relevance 1.14
However, in rats with neuropathic pain, produced by either lumbar 5 ventral root transection (L5 VRT) or spared nerve injury (SNI), spinal application of TNF-alpha induced LTP of C-fiber evoked field potentials.
TNF-alpha Positive_regulation (induced) of LTP in nerve associated with c fibre, nervous system injury, neuropathic pain and long-term potentiation
2) Confidence 0.03 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17084420 Disease Relevance 0.65 Pain Relevance 1.20
These results suggest that TNF-alpha and its downstream molecules may have no acute effect on spinal synaptic transmission in intact animals and induce LTP in rats with neuropathic pain produced by nerve injury.
TNF-alpha Neg (no) Positive_regulation (induce) of LTP in spinal associated with nervous system injury, neuropathic pain and long-term potentiation
3) Confidence 0.03 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17084420 Disease Relevance 0.77 Pain Relevance 1.13
Spinal application of JNK inhibitor (SP600125) or p38 MAPK inhibitor (SB203580) did not affect the spinal LTP induced by tetanic stimulation in intact rats, but completely blocked LTP induced by TNF-alpha in L5 VRT rats.
TNF-alpha Positive_regulation (induced) of LTP in spinal associated with long-term potentiation
4) Confidence 0.03 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17084420 Disease Relevance 0.60 Pain Relevance 1.16

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox