INT139723

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 2.98
Pain Relevance 2.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MAPK8) mitochondrion (MAPK8) response to stress (MAPK8)
cytoplasm (MAPK8) cytosol (MAPK8) extracellular space (PROC)
Anatomy Link Frequency
dorsal horn 2
PROC (Homo sapiens)
MAPK8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dorsal horn neuron 2 100.00 Very High Very High Very High
Inflammatory mediators 4 99.80 Very High Very High Very High
Pain 24 96.88 Very High Very High Very High
central sensitization 4 93.00 High High
Analgesic 2 84.08 Quite High
Dorsal horn 2 64.12 Quite High
Central nervous system 2 63.36 Quite High
Inflammation 2 62.56 Quite High
Peripheral sensitization 2 61.96 Quite High
Neuropathic pain 4 61.20 Quite High
Disease Link Frequency Relevance Heat
Nociception 4 100.00 Very High Very High Very High
INFLAMMATION 6 99.80 Very High Very High Very High
Pain 18 96.88 Very High Very High Very High
Injury 8 94.88 High High
Disease 2 81.32 Quite High
Neuropathic Pain 4 61.20 Quite High
Nervous System Injury 2 53.08 Quite High
Inflammatory Pain 2 52.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In particular, mitogen-activated protein kinases (MAPKs), consisting of extracellular signal-regulated kinase (ERK), p38, and c-Jun N-terminal kinase (JNK), are downstream to many kinases and are activated in primary sensory and dorsal horn neurons by nociceptive activity, growth factors and inflammatory mediators, contributing to the induction and maintenance of pain sensitization via posttranslational, translational, and transcriptional regulation.
factors Positive_regulation (activated) of JNK in dorsal horn associated with nociception, pain, inflammatory mediators and dorsal horn neuron
1) Confidence 0.01 Published 2007 Journal Handb Exp Pharmacol Section Abstract Doc Link 17087130 Disease Relevance 1.46 Pain Relevance 1.13
In particular, mitogen-activated protein kinases (MAPKs), consisting of extracellular signal-regulated kinase (ERK), p38, and c-Jun N-terminal kinase (JNK), are downstream to many kinases and are activated in primary sensory and dorsal horn neurons by nociceptive activity, growth factors and inflammatory mediators, contributing to the induction and maintenance of pain sensitization via posttranslational, translational, and transcriptional regulation.
factors Positive_regulation (activated) of c-Jun N-terminal kinase in dorsal horn associated with nociception, pain, inflammatory mediators and dorsal horn neuron
2) Confidence 0.01 Published 2007 Journal Handb Exp Pharmacol Section Abstract Doc Link 17087130 Disease Relevance 1.52 Pain Relevance 1.19

General Comments

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