INT139724

Context Info Confidence 0.00 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 1.57 Pain Relevance 1.25

nucleoplasm (MAPK14) response to stress (MAPK14) cytoplasm (MAPK14) cytosol (MAPK14) signal transduction (MAPK14) extracellular space (PROC)

Anatomy Link Frequency dorsal horn 1 PROC (Homo sapiens) MAPK14 (Homo sapiens)

Pain Link Frequency Relevance Heat Dorsal horn neuron 1 100.00 Inflammatory mediators 2 99.80 Pain 12 96.88 central sensitization 2 93.36 Analgesic 1 84.44 Dorsal horn 1 64.48 Central nervous system 1 63.72 Inflammation 1 62.56 Peripheral sensitization 1 62.32 Neuropathic pain 2 61.20

Disease Link Frequency Relevance Heat Nociception 2 100.00 INFLAMMATION 3 99.80 Pain 9 96.88 Injury 4 95.24 Disease 1 81.68 Neuropathic Pain 2 61.20 Nervous System Injury 1 53.44 Inflammatory Pain 1 52.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In particular, mitogen-activated protein kinases (MAPKs), consisting of extracellular signal-regulated kinase (ERK), p38, and c-Jun N-terminal kinase (JNK), are downstream to many kinases and are activated in primary sensory and dorsal horn neurons by nociceptive activity, growth factors and inflammatory mediators, contributing to the induction and maintenance of pain sensitization via posttranslational, translational, and transcriptional regulation.

factors Positive_regulation (activated) of p38 in dorsal horn associated with nociception, pain, inflammatory mediators and dorsal horn neuron

1) Confidence 0.00 Published 2007 Journal Handb Exp Pharmacol Section Abstract Doc Link 17087130 Disease Relevance 1.57 Pain Relevance 1.25

General Comments

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