INT139725

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.10
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CDCP1) plasma membrane (CDCP1)
Anatomy Link Frequency
neuronal 1
CDCP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Analgesic 1 99.80 Very High Very High Very High
GABA receptor 5 97.00 Very High Very High Very High
Pain 12 94.68 High High
cytokine 4 90.80 High High
central sensitization 2 84.00 Quite High
Inflammation 13 82.84 Quite High
Dorsal horn 1 82.04 Quite High
Central nervous system 1 81.28 Quite High
Peripheral sensitization 1 79.88 Quite High
nociceptor 1 78.52 Quite High
Disease Link Frequency Relevance Heat
Disease 38 99.24 Very High Very High Very High
Pain 9 94.68 High High
Injury 4 87.88 High High
Stress 2 85.28 High High
Reperfusion Injury 1 84.60 Quite High
Cv Unclassified Under Development 1 83.84 Quite High
INFLAMMATION 17 82.84 Quite High
Contact Dermatitis 1 75.76 Quite High
Colitis 1 73.04 Quite High
Inflammatory Pain 2 72.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although protein kinases were not favored as targets for analgesics, studies in the last decade have demonstrated important roles of these kinases in regulating neuronal plasticity and pain sensitization.
kinases Binding (targets) of in neuronal associated with pain and analgesic
1) Confidence 0.01 Published 2007 Journal Handb Exp Pharmacol Section Abstract Doc Link 17087130 Disease Relevance 1.13 Pain Relevance 1.09
The STRING network showed a clear tendency to associate phthalates with kinases and nuclear receptors.
kinases Spec (clear) Binding (associate) of
2) Confidence 0.00 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2873901 Disease Relevance 0.06 Pain Relevance 0.05
This includes the mitogen-activated protein kinases, principally ERKs [15] mediated via interaction with the beta arrestins [16].
kinases Binding (interaction) of
3) Confidence 0.00 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0.91 Pain Relevance 0.26

General Comments

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