INT139731

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Context Info
Confidence 0.22
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.09
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Sstr3) cytoplasm (Sstr3) signal transducer activity (Sstr3)
Anatomy Link Frequency
spinal 2
Sstr3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 1 100.00 Very High Very High Very High
Paracetamol 7 98.02 Very High Very High Very High
Antinociceptive 2 94.72 High High
Pain 3 94.60 High High
antinociception 3 75.68 Quite High
analgesia 1 75.00 Quite High
Analgesic 1 64.56 Quite High
Disease Link Frequency Relevance Heat
Pain 1 94.60 High High
Nociception 2 32.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show that acetaminophen indirectly stimulates spinal 5-hydroxytryptamine (5-HT)1A receptors in the formalin test, thereby increasing transcript and protein levels of low-affinity neurotrophin receptor, insulin-like growth factor-1 (IGF-1) receptor alpha subunit, and growth hormone receptor and reducing the amount of somatostatin 3 receptor (sst3R) mRNA.
Positive_regulation (increasing) of Transcription (transcript) of somatostatin 3 receptor in spinal associated with paracetamol and somatostatin
1) Confidence 0.22 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17088403 Disease Relevance 0.09 Pain Relevance 1.08

General Comments

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