INT139735

Context Info Confidence 0.53 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 4 Total Number 4 Disease Relevance 1.93 Pain Relevance 2.49

extracellular space (Igf1) extracellular region (Igf1)

Anatomy Link Frequency spinal 4 spinal cord 2 Igf1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Spinal cord 6 100.00 Calcitonin gene-related peptide 5 100.00 Paracetamol 14 98.02 Somatostatin 2 96.76 Pain 6 94.60 antagonist 1 92.64 cytokine 52 88.24 dorsal root ganglion 1 88.08 Antinociceptive 4 86.40 analgesia 4 75.00

Disease Link Frequency Relevance Heat Frailty 9 98.56 Sepsis 37 98.12 Pain 2 94.60 Cancer 2 93.36 Necrosis 2 92.88 Ganglion Cysts 1 88.08 Apoptosis 1 87.84 Injury 3 85.04 Starvation 5 77.20 INFLAMMATION 4 72.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Nutrition increased the expression of mRNA of both IGF-I and the GHR, while these were not affected by sepsis.

Positive_regulation (increased) of Transcription (expression) of IGF-I associated with sepsis

1) Confidence 0.53 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.49 Pain Relevance 0.09

We show that acetaminophen indirectly stimulates spinal 5-hydroxytryptamine (5-HT)1A receptors in the formalin test, thereby increasing transcript and protein levels of low-affinity neurotrophin receptor, insulin-like growth factor-1 (IGF-1) receptor alpha subunit, and growth hormone receptor and reducing the amount of somatostatin 3 receptor (sst3R) mRNA.

Positive_regulation (increasing) of Transcription (levels) of IGF-1 in spinal associated with paracetamol and somatostatin

2) Confidence 0.46 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17088403 Disease Relevance 0.09 Pain Relevance 0.93

The intravenous administration of limaprost enhanced increases of spinal cord tissue levels of CGRP, IGF-I, and IGF-I mRNA at 2 h after the induction of SCI.

Positive_regulation (increases) of Transcription (levels) of IGF-I in spinal cord associated with frailty, calcitonin gene-related peptide and spinal cord

3) Confidence 0.45 Published 2010 Journal Transl Res Section Abstract Doc Link 20970752 Disease Relevance 1.25 Pain Relevance 0.55

We show that acetaminophen indirectly stimulates spinal 5-hydroxytryptamine (5-HT)1A receptors in the formalin test, thereby increasing transcript and protein levels of low-affinity neurotrophin receptor, insulin-like growth factor-1 (IGF-1) receptor alpha subunit, and growth hormone receptor and reducing the amount of somatostatin 3 receptor (sst3R) mRNA.

Positive_regulation (increasing) of Transcription (transcript) of insulin-like growth factor-1 in spinal associated with paracetamol and somatostatin

4) Confidence 0.38 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17088403 Disease Relevance 0.09 Pain Relevance 0.93

General Comments

This test has worked.