INT139735

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Context Info
Confidence 0.53
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.93
Pain Relevance 2.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igf1) extracellular region (Igf1)
Anatomy Link Frequency
spinal 4
spinal cord 2
Igf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 6 100.00 Very High Very High Very High
Calcitonin gene-related peptide 5 100.00 Very High Very High Very High
Paracetamol 14 98.02 Very High Very High Very High
Somatostatin 2 96.76 Very High Very High Very High
Pain 6 94.60 High High
antagonist 1 92.64 High High
cytokine 52 88.24 High High
dorsal root ganglion 1 88.08 High High
Antinociceptive 4 86.40 High High
analgesia 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Frailty 9 98.56 Very High Very High Very High
Sepsis 37 98.12 Very High Very High Very High
Pain 2 94.60 High High
Cancer 2 93.36 High High
Necrosis 2 92.88 High High
Ganglion Cysts 1 88.08 High High
Apoptosis 1 87.84 High High
Injury 3 85.04 High High
Starvation 5 77.20 Quite High
INFLAMMATION 4 72.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nutrition increased the expression of mRNA of both IGF-I and the GHR, while these were not affected by sepsis.
Positive_regulation (increased) of Transcription (expression) of IGF-I associated with sepsis
1) Confidence 0.53 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.49 Pain Relevance 0.09
We show that acetaminophen indirectly stimulates spinal 5-hydroxytryptamine (5-HT)1A receptors in the formalin test, thereby increasing transcript and protein levels of low-affinity neurotrophin receptor, insulin-like growth factor-1 (IGF-1) receptor alpha subunit, and growth hormone receptor and reducing the amount of somatostatin 3 receptor (sst3R) mRNA.
Positive_regulation (increasing) of Transcription (levels) of IGF-1 in spinal associated with paracetamol and somatostatin
2) Confidence 0.46 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17088403 Disease Relevance 0.09 Pain Relevance 0.93
The intravenous administration of limaprost enhanced increases of spinal cord tissue levels of CGRP, IGF-I, and IGF-I mRNA at 2 h after the induction of SCI.
Positive_regulation (increases) of Transcription (levels) of IGF-I in spinal cord associated with frailty, calcitonin gene-related peptide and spinal cord
3) Confidence 0.45 Published 2010 Journal Transl Res Section Abstract Doc Link 20970752 Disease Relevance 1.25 Pain Relevance 0.55
We show that acetaminophen indirectly stimulates spinal 5-hydroxytryptamine (5-HT)1A receptors in the formalin test, thereby increasing transcript and protein levels of low-affinity neurotrophin receptor, insulin-like growth factor-1 (IGF-1) receptor alpha subunit, and growth hormone receptor and reducing the amount of somatostatin 3 receptor (sst3R) mRNA.
Positive_regulation (increasing) of Transcription (transcript) of insulin-like growth factor-1 in spinal associated with paracetamol and somatostatin
4) Confidence 0.38 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17088403 Disease Relevance 0.09 Pain Relevance 0.93

General Comments

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