INT13974

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Context Info
Confidence 0.35
First Reported 1989
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.05
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grpr) signal transducer activity (Grpr)
Anatomy Link Frequency
intrinsic neurons 1
neurons 1
superior mesenteric ganglion 1
Grpr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 10 100.00 Very High Very High Very High
Enkephalin 6 100.00 Very High Very High Very High
Neuropeptide 6 99.88 Very High Very High Very High
Calcitonin gene-related peptide 5 99.88 Very High Very High Very High
tetrodotoxin 7 99.00 Very High Very High Very High
Cholecystokinin 2 98.28 Very High Very High Very High
substance P 1 89.60 High High
agonist 4 82.72 Quite High
Neurotransmitter 4 79.24 Quite High
antagonist 2 73.28 Quite High
Disease Link Frequency Relevance Heat
Celiac Disease 4 96.92 Very High Very High Very High
Ganglion Cysts 10 95.80 Very High Very High Very High
Diabetes Mellitus 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bombesin/GRP-stimulated somatostatin secretion is mediated by gastrin in the antrum and intrinsic neurons in the fundus.
Localization (secretion) of Bombesin/GRP-stimulated in intrinsic neurons associated with somatostatin
1) Confidence 0.35 Published 1991 Journal Am. J. Physiol. Section Title Doc Link 1683168 Disease Relevance 0 Pain Relevance 0.55
Bombesin-stimulated G-IR secretion was strongly reduced by tetrodotoxin, whereas atropine had no effect.
Localization (secretion) of Bombesin-stimulated associated with tetrodotoxin
2) Confidence 0.04 Published 2000 Journal Endocrinology Section Abstract Doc Link 10875263 Disease Relevance 0 Pain Relevance 0.23
The localization of bombesin- (BOMB) and enkephalin- (ENK) immunoreactive (IR) nerves was studied in rat coeliac-superior mesenteric ganglion complex in relation to neuropeptide Y (NPY)- and tyrosine hydroxylase (TH)-immunoreactive neurons with an immunofluorescence double-staining method.
Localization (localization) of bombesin in neurons associated with ganglion cysts, celiac disease, neuropeptide and enkephalin
3) Confidence 0.04 Published 1989 Journal Histochemistry Section Abstract Doc Link 2570773 Disease Relevance 0.47 Pain Relevance 0.26
Localization of bombesin-, neuropeptide Y-, enkephalin- and tyrosine hydroxylase-like immunoreactivities in rat coeliac-superior mesenteric ganglion.
Localization (Localization) of bombesin in superior mesenteric ganglion associated with ganglion cysts, celiac disease, neuropeptide and enkephalin
4) Confidence 0.04 Published 1989 Journal Histochemistry Section Title Doc Link 2570773 Disease Relevance 0.58 Pain Relevance 0.39
Tetrodotoxin did not modify the bethanechol-, isoproterenol-, calcitonin gene-related peptide-, or bombesin-induced GLP-1 release.
Localization (release) of bombesin associated with tetrodotoxin and calcitonin gene-related peptide
5) Confidence 0.02 Published 1994 Journal Endocrinology Section Abstract Doc Link 7988423 Disease Relevance 0 Pain Relevance 0.38
Bombesin (10(-9)-10(-7) M) provoked a dose-dependent release of GLP-1, consisting of an early peak, followed by a sustained response.
Localization (release) of Bombesin
6) Confidence 0.02 Published 1994 Journal Endocrinology Section Abstract Doc Link 7988423 Disease Relevance 0 Pain Relevance 0.34

General Comments

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