INT139741

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Context Info
Confidence 0.38
First Reported 2006
Last Reported 2006
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.33
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ACVRL1)
Anatomy Link Frequency
tubes 2
smooth muscle 2
ACVRL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 8 97.52 Very High Very High Very High
imagery 2 82.64 Quite High
Pain 1 73.40 Quite High
cytokine 2 39.20 Quite Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
Serotonin 5 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
fluoxetine 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 6 97.52 Very High Very High Very High
Hypoxia 9 94.32 High High
Hepatocellular Cancer 1 90.40 High High
Hemangiosarcoma 1 89.24 High High
Pulmonary Hypertension 85 88.16 High High
Malignant Neoplastic Disease 1 85.08 High High
Anaemia 1 80.52 Quite High
Hepatomegaly 1 76.00 Quite High
Cancer 8 75.00 Quite High
Fatigue 1 74.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The spindle cells were strongly reactive for smooth muscle actin but negative for ALK-1.
Positive_regulation (reactive) of Neg (negative) Gene_expression (negative) of ALK-1 in smooth muscle
1) Confidence 0.38 Published 2006 Journal Arch. Pathol. Lab. Med. Section Abstract Doc Link 17090200 Disease Relevance 1.03 Pain Relevance 0.28
Intriguingly, ROBO4 is upregulated in mice lacking the ALK-1 gene, which is mutated in some cases of FPAH, and these mice characteristically have aberrant fusion of endothelial tubes [33].
Positive_regulation (upregulated) of Gene_expression (mutated) of ALK-1 gene in tubes
2) Confidence 0.08 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 0.30 Pain Relevance 0

General Comments

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