INT139745

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Context Info
Confidence 0.28
First Reported 2007
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.14
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1, Arrb2) plasma membrane (Oprm1, Arrb2) transport (Arrb2)
nucleus (Arrb2) intracellular (Arrb2) cytoplasm (Arrb2)
Oprm1 (Mus musculus)
Arrb2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 3 94.56 High High
Morphine 3 90.08 High High
Enkephalin 1 87.76 High High
opioid receptor 3 75.72 Quite High
MU agonist 1 75.00 Quite High
tolerance 1 70.32 Quite High
depression 1 67.04 Quite High
opiate 2 55.92 Quite High
Analgesic 1 55.36 Quite High
Pain 1 44.40 Quite Low
Disease Link Frequency Relevance Heat
Constipation 1 69.44 Quite High
Respiratory Failure 1 68.00 Quite High
Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is interesting that this compound, termed herkinorin, does not promote the recruitment of beta-arrestin-2 to the muOR and does not lead to receptor internalization.
Neg (not) Positive_regulation (promote) of muOR Neg (not) Binding (recruitment) of beta-arrestin-2
1) Confidence 0.28 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17090705 Disease Relevance 0.14 Pain Relevance 0.81

General Comments

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