INT139749

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Context Info
Confidence 0.02
First Reported 2006
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 10
Total Number 15
Disease Relevance 2.47
Pain Relevance 5.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ubqln1) nucleus (Ubqln1) protein complex (Ubqln1)
cytoplasm (Ubqln1)
Anatomy Link Frequency
dorsal 1
neuronal 1
striatum 1
lever 1
motoneurons 1
Ubqln1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 1264 100.00 Very High Very High Very High
Nucleus accumbens 385 99.40 Very High Very High Very High
depression 7 98.84 Very High Very High Very High
cocaine 28 98.28 Very High Very High Very High
alcohol 10 97.16 Very High Very High Very High
tolerance 7 96.84 Very High Very High Very High
Opioid 9 96.08 Very High Very High Very High
addiction 14 95.80 Very High Very High Very High
Eae 35 84.96 Quite High
Neurotransmitter 38 84.08 Quite High
Disease Link Frequency Relevance Heat
Manic Depressive Disorder 7 99.68 Very High Very High Very High
Cognitive Disorder 69 99.44 Very High Very High Very High
Depression 7 98.84 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 7 98.36 Very High Very High Very High
Apoptosis 7 97.36 Very High Very High Very High
Opiate Addiction 7 96.08 Very High Very High Very High
Sprains And Strains 41 88.76 High High
Diabetes Mellitus 42 88.44 High High
Appetite Loss 7 77.84 Quite High
Drug Dependence 14 73.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Naloxone treatment did not modify the 3,4-dihydroxyphenylacetic acid/DA (DOPAC/DA) ratio or serum prolactin concentration in control rats.
Neg (not) Regulation (modify) of DA
1) Confidence 0.02 Published 2006 Journal Neuroendocrinology Section Body Doc Link 17090971 Disease Relevance 0 Pain Relevance 0
Changes in extracellular DA levels in the NAc were compared after limited and extended training sessions, while rats lever pressed for food reward on a RI 30-s schedule.
Regulation (Changes) of DA in lever associated with nucleus accumbens and dopamine
2) Confidence 0.01 Published 2006 Journal Psychopharmacology (Berl) Section Body Doc Link PMC1820758 Disease Relevance 0 Pain Relevance 0.20
Important insights into the role of DA transmission at different stages of instrumental behavior may be gained by examining in vivo changes in DA levels in major areas of DA innervation.
Spec (examining) Regulation (changes) of DA associated with dopamine
3) Confidence 0.01 Published 2006 Journal Psychopharmacology (Berl) Section Body Doc Link PMC1820758 Disease Relevance 0 Pain Relevance 0.47
We also examined changes in DA levels in the MD striatum, as a control site for generalized activity; hence, we predicted no significant changes in DA efflux associated with instrumental responding.
Spec (examined) Regulation (changes) of DA in striatum associated with dopamine
4) Confidence 0.01 Published 2006 Journal Psychopharmacology (Berl) Section Body Doc Link PMC1820758 Disease Relevance 0 Pain Relevance 0.61
In line with previous reports (e.g., Parkinson et al., 2002; Robbins, Giardini, Jones, Reading, & Sahakian, 1990), secondary changes in DA levels were also observed in the mPFC and CPu.
Regulation (changes) of DA associated with dopamine
5) Confidence 0.01 Published 2010 Journal Behav Neurosci Section Body Doc Link PMC3002220 Disease Relevance 0.15 Pain Relevance 0.33
Some changes in DA levels were also found in the three control regions that were selected on the basis of their location (CPu dorsal) and known interconnectivity (IL and PL).
Regulation (changes) of DA in dorsal associated with dopamine
6) Confidence 0.01 Published 2010 Journal Behav Neurosci Section Body Doc Link PMC3002220 Disease Relevance 0.06 Pain Relevance 0.35
The systematic relationship between core DA levels and performance in the object recognition task clearly points to the importance of core DA in mediating the underlying processes necessary to performance on this task.
Regulation (importance) of DA associated with cognitive disorder and dopamine
7) Confidence 0.01 Published 2010 Journal Behav Neurosci Section Body Doc Link PMC3002220 Disease Relevance 0.34 Pain Relevance 0.41
Our data suggest that it is unlikely that the reduced DA efflux is a consequence of changes in tissue DA content.
Regulation (changes) of DA associated with dopamine
8) Confidence 0.01 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.56
Therefore, in light of these data, it is possible that the regulation of AMPH-induced DA efflux—promoted by insulin and PI3K signaling—is mediated by changes in DAT cell surface expression.
Spec (possible) Regulation (regulation) of DA associated with dopamine
9) Confidence 0.01 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.08 Pain Relevance 0.24
DA clearance is dynamically modulated by several signaling pathways [8–10].
Regulation (modulated) of DA associated with dopamine
10) Confidence 0.01 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.37 Pain Relevance 0.49
These data suggest that insulin signaling pathways may represent a novel mechanism for regulating DA transmission, one which may be targeted for the treatment of AMPH abuse and potentially other dopaminergic disorders.


Regulation (regulating) of DA associated with dopamine
11) Confidence 0.01 Published 2007 Journal PLoS Biology Section Abstract Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.26
Recently, the PI3K/Akt signaling pathway has been shown to regulate DA clearance [11] and has been implicated in cocaine sensitization [26], alcohol tolerance [27] and opioid dependence [28].
Regulation (regulate) of DA associated with addiction, dopamine, tolerance, opioid, alcohol and cocaine
12) Confidence 0.01 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.38 Pain Relevance 0.63
Our data suggest that it is unlikely that the reduced DA efflux is a consequence of changes in tissue DA content.
Regulation (changes) of DA associated with dopamine
13) Confidence 0.01 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.56
Considering that the striatum is highly enriched in insulin [17,62] and IRs [15,17,18], as well as in DAT [37–39], these studies strongly support a role for the neuronal PI3K pathway in regulating DAT activity and extracellular DA levels, as well as in the actions of AMPH.
Regulation (regulating) of DA in neuronal associated with dopamine
14) Confidence 0.01 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.36 Pain Relevance 0.28
In a first experiment, survival of motoneurons 21 days after VRA in congenic animals was compared to parental DA controls, showing a significantly increased survival of axotomized cells in R1 (p<0.05), but not R2 animals.
Regulation (controls) of DA in motoneurons
15) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691596 Disease Relevance 0.72 Pain Relevance 0

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