INT139767

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Context Info
Confidence 0.30
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.59
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ICK, TRPV1) transport (TRPV1) signal transduction (ICK)
plasma membrane (TRPV1) nucleus (ICK) lipid metabolic process (TRPV1)
Anatomy Link Frequency
sensory neurons 2
ICK (Homo sapiens)
TRPV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 4 100.00 Very High Very High Very High
Pain 14 97.56 Very High Very High Very High
agonist 2 83.28 Quite High
TRP channel 6 78.32 Quite High
IPN 2 75.00 Quite High
potassium channel 2 73.04 Quite High
Inflammation 10 71.60 Quite High
Disease Link Frequency Relevance Heat
Pain 8 97.56 Very High Very High Very High
Death 2 88.24 High High
Paralysis 2 87.88 High High
Shock 2 87.44 High High
Inflammatory Pain 2 75.00 Quite High
INFLAMMATION 4 71.60 Quite High
Bites And Stings 4 69.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we show that venom from a tarantula that is native to the West Indies contains three inhibitor cysteine knot (ICK) peptides that target the capsaicin receptor (TRPV1), an excitatory channel expressed by sensory neurons of the pain pathway.
ICK Regulation (target) of capsaicin receptor in sensory neurons associated with pain and qutenza
1) Confidence 0.30 Published 2006 Journal Nature Section Abstract Doc Link 17093448 Disease Relevance 0.80 Pain Relevance 0.71
Here we show that venom from a tarantula that is native to the West Indies contains three inhibitor cysteine knot (ICK) peptides that target the capsaicin receptor (TRPV1), an excitatory channel expressed by sensory neurons of the pain pathway.
ICK Regulation (target) of TRPV1 in sensory neurons associated with pain and qutenza
2) Confidence 0.30 Published 2006 Journal Nature Section Abstract Doc Link 17093448 Disease Relevance 0.80 Pain Relevance 0.71

General Comments

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