INT13979

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Context Info
Confidence 0.69
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.05
Pain Relevance 1.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Gast, Sst) extracellular space (Sst) signal transduction (Gast)
Anatomy Link Frequency
intrinsic neurons 2
G cells 2
Gast (Rattus norvegicus)
Sst (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 38 100.00 Very High Very High Very High
tetrodotoxin 8 97.84 Very High Very High Very High
Cholecystokinin 2 82.32 Quite High
antagonist 4 74.20 Quite High
depression 1 53.52 Quite High
Neuropeptide 2 40.32 Quite Low
Calcitonin gene-related peptide 13 39.28 Quite Low
agonist 7 32.88 Quite Low
dorsal root ganglion 2 15.40 Low Low
ASIC 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 1 53.52 Quite High
Ganglion Cysts 4 15.40 Low Low
Ulcers 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Dyspepsia 2 5.00 Very Low Very Low Very Low
Loss Of Sense Of Smell 2 5.00 Very Low Very Low Very Low
Nociception 2 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 2 5.00 Very Low Very Low Very Low
Acid Reflux 1 5.00 Very Low Very Low Very Low
Gastritis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gastrin (1 mumol/L) alone significantly stimulated somatostatin release (150% +/- 10% of basal), which was completely attenuated in the presence of gastrin antiserum.
Gastrin Positive_regulation (stimulated) of Localization (release) of somatostatin associated with somatostatin
1) Confidence 0.69 Published 1990 Journal Gastroenterology Section Abstract Doc Link 1976561 Disease Relevance 0.05 Pain Relevance 0.97
Bombesin/GRP-stimulated somatostatin secretion is mediated by gastrin in the antrum and intrinsic neurons in the fundus.
gastrin Positive_regulation (mediated) of Localization (secretion) of somatostatin in intrinsic neurons associated with somatostatin
2) Confidence 0.65 Published 1991 Journal Am. J. Physiol. Section Title Doc Link 1683168 Disease Relevance 0 Pain Relevance 0.55
One feedback pathway is the direct stimulation of D-cell somatostatin release by gastrin [12], which, in turn, indirectly inhibits further gastric release from G cells.
gastrin Positive_regulation (stimulation) of Localization (release) of D-cell somatostatin in G cells associated with somatostatin
3) Confidence 0.03 Published 2010 Journal Curr Gastroenterol Rep Section Body Doc Link PMC2974196 Disease Relevance 0 Pain Relevance 0.23

General Comments

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