INT139801

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Context Info
Confidence 0.66
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 5.20
Pain Relevance 3.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NFKB1) mitochondrion (NFKB1) cytoplasm (NFKB1)
cytosol (NFKB1) signal transduction (NFKB1) nucleolus (NFKB1)
Anatomy Link Frequency
endothelial cell 1
NFKB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 14 99.34 Very High Very High Very High
aspirin 11 98.48 Very High Very High Very High
cytokine 6 98.40 Very High Very High Very High
Inflammation 18 96.80 Very High Very High Very High
COX2 2 95.24 Very High Very High Very High
metalloproteinase 1 94.32 High High
Inflammatory response 1 83.60 Quite High
COX-2 inhibitor 2 80.80 Quite High
cINOD 5 78.96 Quite High
Osteoarthritis 7 75.00 Quite High
Disease Link Frequency Relevance Heat
Death 6 99.72 Very High Very High Very High
Multiple Myeloma 7 99.16 Very High Very High Very High
INFLAMMATION 18 96.80 Very High Very High Very High
Apoptosis 14 94.16 High High
Hypercalcemia 2 90.88 High High
Ovarian Cancer 6 89.76 High High
Stress 3 83.24 Quite High
Squamous Cell Carcinoma 3 83.08 Quite High
Chronic Lymphoid Leukemia 1 78.00 Quite High
Cancer 3 76.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HA also decreased the degree of phosphorylation and nuclear translocation of NF-kappaB enhanced by LPS.
Phosphorylation (phosphorylation) of NF-kappaB
1) Confidence 0.66 Published 2010 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 20208419 Disease Relevance 0.49 Pain Relevance 0.38
Oxidant scavengers and Bay 11-7085 [an inhibitor of nuclear factor kappaB (NF-kappaB) activation] prevented the FLX-induced cell death, increase in phosphorylated inhibitory kappaB-alpha and NF-kappaB p65 levels, and binding of NF-kappaB p65 to DNA.
Phosphorylation (phosphorylated) of kappaB associated with death and fluoxetine
2) Confidence 0.60 Published 2010 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 20050848 Disease Relevance 0.74 Pain Relevance 0.61
Oxidant scavengers and Bay 11-7085 [an inhibitor of nuclear factor kappaB (NF-kappaB) activation] prevented the FLX-induced cell death, increase in phosphorylated inhibitory kappaB-alpha and NF-kappaB p65 levels, and binding of NF-kappaB p65 to DNA.
Phosphorylation (phosphorylated) of NF-kappaB associated with death and fluoxetine
3) Confidence 0.60 Published 2010 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 20050848 Disease Relevance 0.74 Pain Relevance 0.61
IL-1beta-induced NF-kappaB activation was suppressed directly by cocktails of curcumin and resveratrol through inhibition of Ikappakappa and proteasome activation, inhibition of IkappaBalpha phosphorylation and degradation, and inhibition of nuclear translocation of NF-kappaB.
Phosphorylation (phosphorylation) of NF-kappaB
4) Confidence 0.58 Published 2009 Journal Arthritis Res. Ther. Section Body Doc Link 19889203 Disease Relevance 0.05 Pain Relevance 0
SDX-308 effectively suppressed TNF-alpha-induced IKK-gamma and IkappaB-alpha phosphorylation and degradation and subsequent NF-kappaB activation in human multiple myeloma cells.
Phosphorylation (phosphorylation) of NF-kappaB associated with multiple myeloma
5) Confidence 0.51 Published 2007 Journal Blood Section Abstract Doc Link 17095620 Disease Relevance 0.88 Pain Relevance 0.11
Resveratrol, like N-Ac-Leu-Leu-norleucinal (ALLN) suppressed IL-1beta-induced proteasome function and the degradation of IkappaBalpha (an inhibitor of NF-kappaB) without affecting IkappaBalpha kinase activation, IkappaBalpha-phosphorylation or IkappaBalpha-ubiquitination which suppressed nuclear translocation of the p65 subunit of NF-kappaB and its phosphorylation.
Phosphorylation (phosphorylation) of NF-kappaB
6) Confidence 0.51 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18606398 Disease Relevance 0.97 Pain Relevance 0.34
Data of Western blot further demonstrated that aspirin treatment caused activation of caspases, down-regulation of Mcl-1 protein, dephosphorylation of ERK-1/2 and AKT, and also IkappaB-alpha proteolysis-dependent NF-kappaB activation in YD-8 cells.
Phosphorylation (dephosphorylation) of NF-kappaB associated with aspirin
7) Confidence 0.45 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 20116423 Disease Relevance 0.64 Pain Relevance 0.65
This study further addressed that IkappaB kinase (IKK), a phosphorylation-dependent regulator of NF-kappaB, plays an important regulatory role in the TNF-alpha-mediated induction of the inflammatory cell surface molecule ICAM-1.
Phosphorylation (phosphorylation) of NF-kappaB associated with inflammation
8) Confidence 0.42 Published 2007 Journal J. Immunol. Section Abstract Doc Link 17237434 Disease Relevance 0.53 Pain Relevance 0.19
Capsiate inhibited UVB-induced cyclooxygenase-2 (COX-2) expression, extracellular signal-related kinase 1/2 phosphorylation, nuclear translocation of NF-kappaB, and the expression of proinflammatory cytokines and potent angiogenic factors, including vascular endothelial cell growth factor and matrix metalloproteinase-2 (MMP-2) and MMP-9.
Phosphorylation (phosphorylation) of NF-kappaB in endothelial cell associated with metalloproteinase and cytokine
9) Confidence 0.35 Published 2010 Journal Free Radic. Biol. Med. Section Abstract Doc Link 20123015 Disease Relevance 0.16 Pain Relevance 0.24

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