INT139803

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 25
Disease Relevance 26.21
Pain Relevance 5.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PTX3)
Anatomy Link Frequency
liver 4
plasma 3
visceral 2
plaque 2
blood 1
PTX3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 243 100.00 Very High Very High Very High
Angina 120 100.00 Very High Very High Very High
rheumatoid arthritis 122 99.92 Very High Very High Very High
cytokine 50 98.84 Very High Very High Very High
Inflammatory marker 56 98.54 Very High Very High Very High
Inflammatory stimuli 1 96.96 Very High Very High Very High
Dopamine 2 95.84 Very High Very High Very High
Neurotransmitter 6 94.20 High High
Inflammatory response 5 91.12 High High
Arthritis 10 85.84 High High
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 105 100.00 Very High Very High Very High
Dengue 88 100.00 Very High Very High Very High
Arteritis 8 100.00 Very High Very High Very High
INFLAMMATION 302 99.92 Very High Very High Very High
Rheumatoid Arthritis 123 99.92 Very High Very High Very High
Obesity 151 99.84 Very High Very High Very High
Abdominal Obesity 308 99.80 Very High Very High Very High
Hyperlipidemia 58 99.72 Very High Very High Very High
Metabolic Syndrome 365 98.98 Very High Very High Very High
Atherosclerosis 39 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent studies have reported that adipocytes induce PTX3 synthesis by secreting various inflammatory cytokines19) Alberti et al.13) have reported that serum PTX3 concentrations were higher in patients with visceral obesity than those with subcutaneous obesity.
Gene_expression (synthesis) of PTX3 in visceral associated with inflammation, obesity and metabolic syndrome
1) Confidence 0.75 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2910286 Disease Relevance 0.95 Pain Relevance 0.13
PTX3 is produced by the major cell types involved in atherosclerotic lesions in response to inflammatory stimuli, and elevated plasma levels are found in several conditions including acute coronary syndromes (ACS).
Gene_expression (produced) of PTX3 in plasma associated with acute coronary syndrome, atherosclerosis and inflammatory stimuli
2) Confidence 0.73 Published 2009 Journal Thromb. Haemost. Section Abstract Doc Link 19718477 Disease Relevance 0.72 Pain Relevance 0.23
METHODS AND RESULTS: We established a high sensitive plasma ELISA assay system for the detection of PTX3 using monoclonal antibodies.
Gene_expression (detection) of PTX3 in plasma
3) Confidence 0.68 Published 2007 Journal Arterioscler. Thromb. Vasc. Biol. Section Body Doc Link 17095712 Disease Relevance 0.09 Pain Relevance 0
They suggested that the levels of plasma PTX3 had increased in patients with arterial inflammation, especially UAP, and that the detection of PTX3 was due to PTX3 having originated from the atherosclerotic plaque itself, thereby reflecting active atherosclerosis.
Gene_expression (detection) of PTX3 in plaque associated with atherosclerotic plaque, angina, arteritis, inflammation and increased venous pressure under development
4) Confidence 0.67 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2933461 Disease Relevance 1.81 Pain Relevance 0.74
They suggested that the levels of plasma PTX3 had increased in patients with arterial inflammation, especially UAP, and that the detection of PTX3 was due to PTX3 having originated from the atherosclerotic plaque itself, thereby reflecting active atherosclerosis.
Gene_expression (detection) of PTX3 in plaque associated with atherosclerotic plaque, angina, arteritis, inflammation and increased venous pressure under development
5) Confidence 0.67 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2933461 Disease Relevance 1.81 Pain Relevance 0.75
Similarly, PTX3 levels did not correlate with CRP levels and it has been shown that in acute myocardial infarction, their temporal and site distribution are different.10)
Gene_expression (levels) of PTX3 associated with myocardial infarction
6) Confidence 0.65 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2910286 Disease Relevance 1.31 Pain Relevance 0.13
Previous studies have reported that PTX3 is useful as an inflammatory marker in metabolic syndrome patients, and that there is a correlation between PTX3 levels and abdominal obesity.12) A recent study found that in terms of type of abdominal obesity, PTX3 is closely associated with visceral fat tissues and it may also be associated with arteriosclerosis.13) However, studies on the correlation of PTX3 levels with metabolic syndrome or abdominal obesity in cardiovascular disease patients remain limited.
Gene_expression (levels) of PTX3 in visceral associated with cardiovascular disease, abdominal obesity, inflammatory marker, metabolic syndrome and increased venous pressure under development
7) Confidence 0.65 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2910286 Disease Relevance 1.98 Pain Relevance 0.25
When PTX3 levels were compared between those with or without each factor associated with the metabolic syndrome, there was no correlation with the waist circumference in male or female patients (male: r=0.19, p=0.29, female: r=0.48, p=0.34), BMI (r=0.04, p=0.80), triglycerides (r=0.07, p=0.96) HDL-C (r=0.15, p=0.35), blood pressure (SBP: r=0.81, p=0.62, DBP: r=0.15, p=0.37), or fasting blood glucose level (r=0.11, p=0.47).
Gene_expression (levels) of PTX3 in blood associated with obesity, metabolic syndrome and disorder of lipid metabolism
8) Confidence 0.65 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2910286 Disease Relevance 1.65 Pain Relevance 0
overnight, blocked with 5% skim milk, and incubated with EDTA-plasma samples and the standard PTX3 protein at 37?
Gene_expression (protein) of PTX3 in plasma
9) Confidence 0.65 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2910286 Disease Relevance 0.39 Pain Relevance 0
In addition, there was no correlation between PTX3 and CRP levels (r=0.24, p=0.14) (Table 2).


Gene_expression (levels) of PTX3
10) Confidence 0.65 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2910286 Disease Relevance 1.39 Pain Relevance 0
Pitavastatin inhibited the expression of pentraxin 3 (PTX3) related to acute inflammation.26 PTX3 is found to be elevated especially in arterial inflammation in patients with unstable angina pectoris, and increased expression of PTX3 has attracted attention as a new effect of pitavastatin.27

Pharmacokinetics of pitavastatin

Gene_expression (expression) of pentraxin 3 associated with angina, arteritis and inflammation
11) Confidence 0.65 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788597 Disease Relevance 0.57 Pain Relevance 0.31
Pentraxin 3 (PTX3) is a "long" pentraxin that is highly expressed in the heart, whereas C-reactive protein (CRP) is a "short" pentraxin and is produced from the liver.7) In several recent studies,8)9) PTX3 appeared to be not only an early indicator of irreversible myocyte injury, but also a prognostic marker in patients with acute myocardial infarction (AMI).
Gene_expression (expressed) of Pentraxin 3 in liver associated with injury and myocardial infarction
12) Confidence 0.60 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2933461 Disease Relevance 1.26 Pain Relevance 0.04
Pentraxin 3 (PTX3) is a "long" pentraxin that is highly expressed in the heart, whereas C-reactive protein (CRP) is a "short" pentraxin and is produced from the liver.7) In several recent studies,8)9) PTX3 appeared to be not only an early indicator of irreversible myocyte injury, but also a prognostic marker in patients with acute myocardial infarction (AMI).
Gene_expression (expressed) of PTX3 in liver associated with injury and myocardial infarction
13) Confidence 0.60 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2933461 Disease Relevance 1.26 Pain Relevance 0.04
Whereas CRP is a short PTX and is synthesized in the liver upon stimulation with primarily interleukin (IL)-6, PTX3 is a long PTX and is synthesized upon stimulation with diverse cytokines, such as IL-1 and tumor necrosis factor (TNF)-?
Gene_expression (synthesized) of PTX3 in liver associated with necrosis, cancer and cytokine
14) Confidence 0.58 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2910286 Disease Relevance 1.70 Pain Relevance 0.39
CRP and serum PTX3 belong to the same PTX superfamily; nonetheless, CRP is a short PTX synthesized in the liver primarily in response to IL-6 stimulation, and serum PTX3 is a long PTX synthesized in response to stimulation by IL-1 and TNF-?
Gene_expression (synthesized) of PTX3 in liver
15) Confidence 0.58 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2910286 Disease Relevance 0.77 Pain Relevance 0.08
The relationship between serum pentraxin 3 level and cardiovascular risk factors
Gene_expression (level) of pentraxin 3
16) Confidence 0.57 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2910286 Disease Relevance 1.52 Pain Relevance 0
Among these patients, 4 (10%) were on statins; nonetheless, the use of statins did not appear to affect levels of PTX3 (2.35±1.89 vs. 2.32±2.45, p=0.98), CRP (1.85±1.77 vs. 1.09±1.22, p<0.13) or serum lipids and it was not associated with abdominal obesity.


Gene_expression (levels) of PTX3 associated with abdominal obesity
17) Confidence 0.57 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2910286 Disease Relevance 1.37 Pain Relevance 0
The relationship between serum pentraxin 3 concentration and abdominal obesity measured by fat computed tomography
Gene_expression (concentration) of pentraxin 3 in fat associated with abdominal obesity
18) Confidence 0.57 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2910286 Disease Relevance 1.42 Pain Relevance 0
This genome-wide expression analysis also confirms the over-expression of individual biomarkers previously associated with severe dengue, such as the acute phase pentraxin-related protein PTX3, the pro-inflammatory IL-18 cytokine or the anti-inflammatory IL-10 cytokine (Table S2) [11], [12], [15], providing a more comprehensive overview of their implication in the pathophysiology of DSS.
Gene_expression (expression) of PTX3 associated with inflammation, dengue, dengue hemorrhagic fever and cytokine
19) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 1.21 Pain Relevance 0.28
Using similar neurogenic medium (NPMM or Neurobasal), MSC expressed dopaminergic specific genes (En1, En2, LMx1a, Wnt1, Ptx3, and Nuur1 and were positive to GFAP, MAP-2 and NSE but continued to express the neural stem cell marker nestin.
Gene_expression (expressed) of Ptx3 in stem cell
20) Confidence 0.31 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2358905 Disease Relevance 0.08 Pain Relevance 0.24

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