INT139805

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Context Info
Confidence 0.70
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 19
Disease Relevance 14.84
Pain Relevance 2.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PTX3)
Anatomy Link Frequency
Plasma 3
fat 2
T-cells 2
visceral 1
coronary artery 1
PTX3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 76 99.52 Very High Very High Very High
cytokine 13 99.00 Very High Very High Very High
Angina 145 97.64 Very High Very High Very High
Inflammatory response 6 97.14 Very High Very High Very High
dexamethasone 1 93.96 High High
midbrain 5 93.04 High High
cINOD 1 87.64 High High
depression 5 86.44 High High
Dopamine 9 85.28 High High
Central nervous system 7 84.60 Quite High
Disease Link Frequency Relevance Heat
Myocardial Infarction 301 99.72 Very High Very High Very High
Abdominal Obesity 168 99.68 Very High Very High Very High
Emergencies 12 99.66 Very High Very High Very High
INFLAMMATION 112 99.52 Very High Very High Very High
Acute Coronary Syndrome 105 98.88 Very High Very High Very High
Death 55 98.84 Very High Very High Very High
Metabolic Syndrome 162 98.44 Very High Very High Very High
Cv General 3 Under Development 130 97.64 Very High Very High Very High
Apoptosis 23 97.16 Very High Very High Very High
Cardiovascular Disease 58 97.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PTX3 was significantly increased in patients in whom coronary intervention was performed.
Positive_regulation (increased) of PTX3
1) Confidence 0.70 Published 2007 Journal Arterioscler. Thromb. Vasc. Biol. Section Body Doc Link 17095712 Disease Relevance 0.07 Pain Relevance 0
OBJECTIVE: Plasma pentraxin 3 (PTX3) levels are increased in patients with acute myocardial infarction, yet its involvement in unstable angina pectoris (UAP) remains unclear.
Positive_regulation (increased) of PTX3 in Plasma associated with angina and myocardial infarction
2) Confidence 0.70 Published 2007 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 17095712 Disease Relevance 0.54 Pain Relevance 0.53
CONCLUSIONS: The levels of plasma PTX3 were increased in patients with arterial inflammation, especially UAP.
Positive_regulation (increased) of PTX3 in plasma
3) Confidence 0.70 Published 2007 Journal Arterioscler. Thromb. Vasc. Biol. Section Body Doc Link 17095712 Disease Relevance 0.06 Pain Relevance 0
OBJECTIVE: Plasma pentraxin 3 (PTX3) levels are increased in patients with acute myocardial infarction, yet its involvement in unstable angina pectoris (UAP) remains unclear.
Positive_regulation (increased) of Plasma pentraxin 3 in Plasma associated with angina and myocardial infarction
4) Confidence 0.70 Published 2007 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 17095712 Disease Relevance 0.54 Pain Relevance 0.53
Recently, several studies have mentioned that the plasma PTX3 level had increased in patients with heart failure and was independently associated with an increased risk for cardiac events.24)25) Suzuki et al.24) demonstrated that the concentration of plasma PTX3 levels was significantly higher in patients with heart failure than in control subjects and increased with advancing New York Heat Association (NYHA) functional class, especially in severe patients with heart failure and NYHA class III or IV.
Positive_regulation (increased) of PTX3 in heart associated with myocardial infarction
5) Confidence 0.69 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2933461 Disease Relevance 1.18 Pain Relevance 0.20
, and it has been known to be specifically and abundantly present in cardiac muscle.7-9) It has been shown that, unlike CRP, serum PTX3 is rapidly induced by several inflammatory cytokines and primarily secreted from vascular endothelial cells.17) PTX3 secreted from cardiac vascular endothelial cells in response to several immunological signals18) is elevated not only in coronary artery diseases, but also in heart failure and has been reported to correlate with prognosis in heart failure.11)
Positive_regulation (induced) of PTX3 in coronary artery associated with coronary artery disease, inflammation, myocardial infarction and cytokine
6) Confidence 0.67 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2910286 Disease Relevance 0.91 Pain Relevance 0.13
Serum PTX3 concentrations tended to be increased in patients with a large visceral fat area (r=0.41, p<0.01) and total fat area (r=0.39, p=0.01); however, a correlation to subcutaneous fat area (r=0.25, p=0.12) was not detected (Fig. 1).
Positive_regulation (increased) of PTX3 in fat
7) Confidence 0.67 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2910286 Disease Relevance 1.11 Pain Relevance 0
The serum PTX3 concentration showed a significant increase in ST segment elevation myocardial infarction (STEMI) greater than the unstable angina pectoris (UAP) group (2.4±2.1 ng/mL vs. 1.3±0.9 ng/mL, p= 0.017, respectively), but did not show a significant difference between non-ST segment elevation myocardial infarction (NSTEMI) and the UAP group (1.9±1.4 ng/mL vs. 1.3±0.9 ng/mL, p=0.083, respectively).
Positive_regulation (increase) of PTX3 associated with angina and myocardial infarction
8) Confidence 0.47 Published 2010 Journal Korean Circulation Journal Section Abstract Doc Link PMC2933461 Disease Relevance 1.39 Pain Relevance 0.38
Pentraxin 3 (PTX3) was shown to be elevated in the acute phase of acute myocardial infarction (AMI) and to have prognostic significance in AMI patients.
Positive_regulation (elevated) of PTX3 associated with myocardial infarction
9) Confidence 0.47 Published 2010 Journal Korean Circulation Journal Section Abstract Doc Link PMC2933461 Disease Relevance 0.68 Pain Relevance 0
In our results, the role of PTX3 as a prognostic biomarker was shown by an increased serum PTX3 that was closely related to death due to MI, in-hospital or to 6 months, in ACS patients, including STEMI, NSTEMI, and UAP groups.
Positive_regulation (increased) of PTX3 associated with acute coronary syndrome, angina, myocardial infarction and death
10) Confidence 0.47 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2933461 Disease Relevance 1.28 Pain Relevance 0.21
Pentraxin 3 (PTX3) was shown to be elevated in the acute phase of acute myocardial infarction (AMI) and to have prognostic significance in AMI patients.
Positive_regulation (elevated) of Pentraxin 3 associated with myocardial infarction
11) Confidence 0.47 Published 2010 Journal Korean Circulation Journal Section Abstract Doc Link PMC2933461 Disease Relevance 0.68 Pain Relevance 0
Our study revealed that within 2 hours after arrival to the emergency room, the serum PTX3 concentration was elevated to 2.33 ng/mL (normal value: <0.99 ng/mL).
Positive_regulation (elevated) of PTX3 associated with emergencies
12) Confidence 0.45 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2910286 Disease Relevance 0.90 Pain Relevance 0.03
In our study, in acute myocardial infarction patients, subcutaneous fat and visceral fat were measured quantitatively by FAT-CT, and it was observed that increases in PTX3 concentration were significantly associated with increases in visceral fat and abdominal fat areas.
Positive_regulation (increases) of PTX3 in fat associated with myocardial infarction
13) Confidence 0.45 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2910286 Disease Relevance 1.05 Pain Relevance 0.11
In our study, the PTX3 concentration and metabolic syndrome were not correlated, likely because of the small number of patients included and that they had had a myocardial infarction, which alone caused the elevation of the PTX3 level.
Positive_regulation (elevation) of PTX3 associated with metabolic syndrome and myocardial infarction
14) Confidence 0.45 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2910286 Disease Relevance 1.31 Pain Relevance 0.04
Therefore, the elevation of serum PTX3 concentration could be used not only in the diagnosis and prognosis of cardiovascular diseases, but also as a marker predicting abdominal visceral obesity in acute myocardial infarction patients.



Positive_regulation (elevation) of PTX3 in visceral associated with cardiovascular disease, metabolic syndrome and myocardial infarction
15) Confidence 0.45 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2910286 Disease Relevance 1.24 Pain Relevance 0
Inflammatory response pathway members selected in our analysis included IL2RB, carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 (CHST2), nuclear factor of activated T-cells (NFATC3), arachidonate 5-lipoxygenase (ALOX3), and pentraxin-related gene (PTX3).
Positive_regulation (activated) of pentraxin-related gene in T-cells associated with inflammatory response
16) Confidence 0.45 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2290973 Disease Relevance 0.36 Pain Relevance 0.05
Inflammatory response pathway members selected in our analysis included IL2RB, carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 (CHST2), nuclear factor of activated T-cells (NFATC3), arachidonate 5-lipoxygenase (ALOX3), and pentraxin-related gene (PTX3).
Positive_regulation (activated) of PTX3 in T-cells associated with inflammatory response
17) Confidence 0.45 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2290973 Disease Relevance 0.36 Pain Relevance 0.05
To assess the dopaminergic profile of the generated cells, we analysed transcription factors PAX2 [22], [23], PTX3, LMX1b [24]–[27] involved in dopaminergic differentiation finding them upregulated.
Positive_regulation (upregulated) of PTX3
18) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346555 Disease Relevance 0 Pain Relevance 0.20
Our results eliminate a role for a number of potential opsonins, including complement, pentraxin-3, and fibronectin.
Positive_regulation (role) of pentraxin-3
19) Confidence 0.21 Published 2009 Journal J. Immunol. Section Abstract Doc Link 19597001 Disease Relevance 1.02 Pain Relevance 0.24

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