INT139807

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Context Info
Confidence 0.51
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 8.78
Pain Relevance 3.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Braf) plasma membrane (Braf) nucleus (Braf)
kinase activity (Braf) cytoplasm (Braf)
Anatomy Link Frequency
colon 1
Braf (Mus musculus)
Braf - V600E (1)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 33 99.98 Very High Very High Very High
rheumatoid arthritis 148 99.96 Very High Very High Very High
Arthritis 20 95.76 Very High Very High Very High
spinal inflammation 20 94.92 High High
alcohol 4 85.12 High High
aspirin 2 83.28 Quite High
cINOD 2 82.64 Quite High
imagery 12 81.12 Quite High
chemokine 19 63.04 Quite High
cytokine 14 62.44 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 148 99.96 Very High Very High Very High
Targeted Disruption 7 99.88 Very High Very High Very High
Melanoma 10 99.60 Very High Very High Very High
Cancer 150 98.88 Very High Very High Very High
Non-small-cell Lung Cancer 61 98.84 Very High Very High Very High
INFLAMMATION 45 97.08 Very High Very High Very High
Colon Cancer 9 96.20 Very High Very High Very High
Arthritis 24 95.76 Very High Very High Very High
Obesity 2 94.96 High High
Low Back Pain 20 94.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because the association between MC1R variation and BRAF was most apparent in melanomas without evidence of chronic sun damage, Landi et al. hypothesized that UV radiation acted indirectly to promote BRAF-mutant melanoma, which is also consistent with our findings.
Gene_expression (variation) of BRAF associated with melanocortin 1 receptor, melanoma and skin cancer
1) Confidence 0.51 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.74 Pain Relevance 0.42
Peptide P25 on BRAF identifies RA in 21% of anti-CCP negative RA patients
Gene_expression (Peptide) of BRAF associated with rheumatoid arthritis
2) Confidence 0.41 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991030 Disease Relevance 2.08 Pain Relevance 1.23
Peptide P25 on BRAF identifies RA in 21% of anti-CCP negative RA patients
Gene_expression (identifies) of BRAF associated with rheumatoid arthritis
3) Confidence 0.41 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991030 Disease Relevance 2.07 Pain Relevance 1.22
Additional evidence for ERK1/2 in pulmonary tumorigenesis was recently demonstrated in transgenic mice overexpressing mutant B-raf and K-ras.
Gene_expression (overexpressing) of B-raf associated with targeted disruption
4) Confidence 0.39 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2861012 Disease Relevance 1.28 Pain Relevance 0.15
All these cell lines express a kRas and/or a BRAF mutation that constitutively activates signaling through the Raf/MEK/ERK pathway.
Gene_expression (express) of BRAF
5) Confidence 0.33 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661649 Disease Relevance 0.75 Pain Relevance 0
We have previously provided data in support of this proposal by demonstrating the requirement of this kinase within several tumor growth models [26] by employing pHUSH to knockdown the expression of B-Raf in human melanoma cell lines.
Gene_expression (expression) of B-Raf associated with melanoma and cancer
6) Confidence 0.18 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2174931 Disease Relevance 0.89 Pain Relevance 0.08
Of 12 patients with a K-RAS mutation, 6 were treated with gefitinib and no responses were seen, whereas no B-RAF mutations were detected.


Neg (no) Gene_expression (detected) of B-RAF
7) Confidence 0.04 Published 2010 Journal Drug design, development and therapy Section Body Doc Link PMC2880339 Disease Relevance 0.17 Pain Relevance 0
The BRAF V600E mutation and 5 CpG island markers (MINT1, MINT2, MINT31, p16 and hMLH1) were assessed in 1154 cases of colon cancer.
Gene_expression (mutation) of BRAF V600E (V600E) in colon associated with colon cancer
8) Confidence 0.01 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17096326 Disease Relevance 0.80 Pain Relevance 0.23

General Comments

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