INT139827

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Context Info
Confidence 0.57
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 2.91
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCB6) mitochondrion (ABCB6) Golgi apparatus (ABCB6)
ATPase activity (ABCB6) plasma membrane (ABCB6) transmembrane transport (ABCB6)
Anatomy Link Frequency
hematopoietic stem cells 1
brain 1
immune system 1
ABCB6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcium channel 3 99.36 Very High Very High Very High
COX-2 inhibitor 2 89.72 High High
cINOD 3 87.88 High High
Inflammation 4 73.12 Quite High
abdominal pain 3 31.24 Quite Low
Bioavailability 22 5.00 Very Low Very Low Very Low
methadone 15 5.00 Very Low Very Low Very Low
alcohol 12 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
antidepressant 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 14 98.36 Very High Very High Very High
Hypersensitivity 48 97.92 Very High Very High Very High
Cancer 25 96.76 Very High Very High Very High
Anaphylaxis 3 92.24 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 192 91.64 High High
Disease 25 90.20 High High
Breast Cancer 6 82.04 Quite High
INFLAMMATION 2 73.12 Quite High
Genetic Predisposition To Disease 3 72.16 Quite High
Influenza Virus Infection 15 66.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been suggested that some COX-inhibitors can enhance the actions of cytostatics by overcoming multidrug resistance through the inhibition of ABC-transporter proteins.
Negative_regulation (inhibition) of ABC
1) Confidence 0.57 Published 2007 Journal Eur. J. Cancer Section Abstract Doc Link 17097285 Disease Relevance 0.23 Pain Relevance 0.35
Altered or unusual drug metabolism and a susceptible immune system are believed to be important cofactors for the development of drug-related hypersensitivity.24 HIV-infected persons are likely to be at special risk of developing hypersensitivity reactions because of the disease associated perturbations in the immune system.25 Two members of a family who were treated with ABC both developed the HSR suggesting a genetic component to ABC HSR.26 Multiple studies have shown an association of the ABC HSR with HLA-B*5701.27–29 The use of this screening test to identify high risk patients has been shown by Rauch et al to reduce the occurrence of the ABC HSR.30 In this cohort involving more than 260 patients, the authors observed that the use of HLA-B*5701 screening decreased ABC HSR from 7% to <1%.
Negative_regulation (decreased) of ABC in immune system associated with acquired immune deficiency syndrome or hiv infection, hypersensitivity and disease
2) Confidence 0.19 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2835563 Disease Relevance 0.79 Pain Relevance 0
The study found a significantly lower incidence of ABC HSR in the prospective-screening group (3.4%) than in the control group (7.8%), (P < 0.001).32
Negative_regulation (incidence) of ABC
3) Confidence 0.18 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2835563 Disease Relevance 0.48 Pain Relevance 0
There have been case reports of patients who developed the ABC HSR after re-initiation of ABC after a hiatus in taking the medication, but this occurrence is believed to be rare.16 Interestingly, these patients had no symptoms of HSR during the first period of ABC administration.
Negative_regulation (developed) of ABC
4) Confidence 0.18 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2835563 Disease Relevance 0.89 Pain Relevance 0
Inhibitors of ABC transporters can be exploited to enhance the oral bioavailablilty or the brain penetration of various drugs.
Negative_regulation (Inhibitors) of ABC in brain
5) Confidence 0.05 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC1277830 Disease Relevance 0.35 Pain Relevance 0
The final method of overcoming resistance is to administer substances inhibiting ABC transporters with anticancer drugs at the same time.
Negative_regulation (inhibiting) of ABC
6) Confidence 0.05 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC1277830 Disease Relevance 0.07 Pain Relevance 0.03
Although verapamil is best known as a calcium channel blocker, it is also used as an inhibitor of P-glycoprotein, a member of the ATP-binding cassette (ABC) transporter superfamily, which is found in hematopoietic stem cells as well as cancer cells [39].
Negative_regulation (inhibitor) of ABC in hematopoietic stem cells associated with cancer and calcium channel
7) Confidence 0.03 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1373634 Disease Relevance 0.10 Pain Relevance 0.05

General Comments

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