INT139829

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Context Info
Confidence 0.57
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.76
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (AGER) extracellular region (AGER) plasma membrane (AGER)
cytoplasm (AGER)
Anatomy Link Frequency
endothelial cells 2
synovium 2
AGER (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 130 99.84 Very High Very High Very High
methotrexate 20 99.64 Very High Very High Very High
Arthritis 8 99.20 Very High Very High Very High
cytokine 8 95.44 Very High Very High Very High
Inflammation 50 95.20 Very High Very High Very High
adenocard 2 93.64 High High
Osteoarthritis 4 82.88 Quite High
Calcium channel 1 75.00 Quite High
metalloproteinase 2 61.16 Quite High
Angina 1 56.12 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 130 99.84 Very High Very High Very High
Arthritis 10 99.20 Very High Very High Very High
Cancer 6 97.12 Very High Very High Very High
Necrosis 6 96.84 Very High Very High Very High
Calcification 8 96.20 Very High Very High Very High
Adhesions 2 95.88 Very High Very High Very High
Atherosclerosis 6 95.32 Very High Very High Very High
INFLAMMATION 54 95.20 Very High Very High Very High
Diabetes Mellitus 12 94.68 High High
Osteoarthritis 4 82.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since we, along with others, have shown that nifedipine inhibits glycation of low-density lipoprotein in vitro and blocks the AGE-induced RAGE expression in endothelial cells through its anti-oxidative properties, nifedipine could inhibit vascular calcification by blocking the AGE formation or the downstream signaling in diabetes.
Negative_regulation (blocks) of Gene_expression (expression) of RAGE in endothelial cells associated with calcification and diabetes mellitus
1) Confidence 0.57 Published 2007 Journal Med. Hypotheses Section Abstract Doc Link 17097822 Disease Relevance 1.59 Pain Relevance 0.09
Methotrexate is also known to downregulate EN-RAGE expression in the synovium of arthritis patients [19] and to suppress activity of tumour necrosis factor alpha [25,27], the cytokine that has been shown to upregulate cellular RAGE [28].
Negative_regulation (downregulate) of Gene_expression (expression) of RAGE in synovium associated with necrosis, cancer, methotrexate, cytokine and arthritis
2) Confidence 0.44 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.99 Pain Relevance 0.61
An alternative explanation for the decreased sRAGE levels in RA might be a true consumption of this molecule.
Negative_regulation (decreased) of Gene_expression (levels) of sRAGE associated with rheumatoid arthritis
3) Confidence 0.32 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 1.19 Pain Relevance 0.59

General Comments

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