INT139830

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 2005
Last Reported 2008
Negated 1
Speculated 4
Reported most in Body
Documents 47
Total Number 51
Disease Relevance 41.71
Pain Relevance 16.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (AGER) extracellular region (AGER) plasma membrane (AGER)
cytoplasm (AGER)
Anatomy Link Frequency
synovial fluid 7
blood 4
joint 3
endothelial cells 3
white blood cell 3
AGER (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 3120 99.84 Very High Very High Very High
methotrexate 480 99.32 Very High Very High Very High
Arthritis 192 99.20 Very High Very High Very High
Inflammation 1212 99.12 Very High Very High Very High
metalloproteinase 48 99.00 Very High Very High Very High
cytokine 196 96.76 Very High Very High Very High
Osteoarthritis 96 93.64 High High
adenocard 48 93.00 High High
imagery 48 92.80 High High
Inflammatory response 98 90.40 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 3120 99.84 Very High Very High Very High
Disease 1188 99.80 Very High Very High Very High
Arthritis 240 99.20 Very High Very High Very High
INFLAMMATION 1312 99.12 Very High Very High Very High
Arthropathy 336 98.64 Very High Very High Very High
Diabetes Mellitus 196 98.36 Very High Very High Very High
Cancer 146 97.12 Very High Very High Very High
Necrosis 146 96.84 Very High Very High Very High
Pathologic Processes 48 96.80 Very High Very High Very High
Renal Disease 88 96.30 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since we, along with others, have shown that nifedipine inhibits glycation of low-density lipoprotein in vitro and blocks the AGE-induced RAGE expression in endothelial cells through its anti-oxidative properties, nifedipine could inhibit vascular calcification by blocking the AGE formation or the downstream signaling in diabetes.
Gene_expression (expression) of RAGE in endothelial cells associated with calcification and diabetes mellitus
1) Confidence 0.75 Published 2007 Journal Med. Hypotheses Section Abstract Doc Link 17097822 Disease Relevance 1.58 Pain Relevance 0.09
Therefore, we could not test whether LTA, TNF and AGER polymorphisms are in linkage disequilibrium in type 1 diabetic patients as suggested by Laki et. al. who recently showed that the HLA 8.1 ancestral haplotype (8.1 AH) was strongly linked to the AGER -429T?
Spec (whether) Gene_expression (polymorphisms) of AGER associated with diabetes mellitus
2) Confidence 0.67 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429972 Disease Relevance 0.67 Pain Relevance 0
Foell and colleagues have recently reported that extracellular newly identified RAGE-binding protein (EN-RAGE), a member of the S100/calgranulin family, was strongly expressed in inflamed synovial tissue.
Gene_expression (expressed) of RAGE
3) Confidence 0.67 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 1.03 Pain Relevance 0.50
Foell and colleagues have recently reported that extracellular newly identified RAGE-binding protein (EN-RAGE), a member of the S100/calgranulin family, was strongly expressed in inflamed synovial tissue.
Gene_expression (expressed) of RAGE
4) Confidence 0.67 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 1.04 Pain Relevance 0.51
The haplotypic structure is complex and there is also a complex interaction between genes and gene products, as illustrated by the TNF gene polymorphism that can influence transcription of LTA [8], and receptor for advanced glycation end-products (RAGE), which after binding to its ligand can increase production of pro-inflammatory cytokines, among them TNF-?
Gene_expression (products) of RAGE associated with inflammation and cytokine
5) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429972 Disease Relevance 0.61 Pain Relevance 0.14
In humans, sRAGE is produced by alternative splicing of RAGE mRNA [6-8].
Gene_expression (produced) of sRAGE
6) Confidence 0.58 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.50 Pain Relevance 0.25
Methotrexate is also known to downregulate EN-RAGE expression in the synovium of arthritis patients [19] and to suppress activity of tumour necrosis factor alpha [25,27], the cytokine that has been shown to upregulate cellular RAGE [28].
Gene_expression (expression) of RAGE in synovium associated with necrosis, cancer, methotrexate, cytokine and arthritis
7) Confidence 0.58 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.98 Pain Relevance 0.61
Experiments to date have shown that pericytes and endothelial cells produce and release RAGE extracellularly, suggesting the presence of a negative feedback mechanism and immune surveillance mechanisms in RAGE signalling [7].
Gene_expression (produce) of RAGE in endothelial cells
8) Confidence 0.58 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.61 Pain Relevance 0.23
All sRAGE values are expressed showing the median and the mean ± standard error of the mean.
Gene_expression (expressed) of sRAGE
9) Confidence 0.58 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.33 Pain Relevance 0.07
In addition, it has also been shown that pericytes and endothelial cells produce and release sRAGE extracellularly, suggesting the presence of a negative feedback mechanism in RAGE signalling [7].
Gene_expression (produce) of sRAGE in endothelial cells
10) Confidence 0.58 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.57 Pain Relevance 0.26
Moreover, synovial fibroblasts that account for about 50% of the cellular constituents of the synovial lining layer constitutively express RAGE [4].
Gene_expression (express) of RAGE in fibroblasts
11) Confidence 0.52 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.71 Pain Relevance 0.31
Correlation between sRAGE levels and clinical features of RA
Gene_expression (levels) of sRAGE associated with rheumatoid arthritis
12) Confidence 0.50 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.72 Pain Relevance 0.32
It is thus probable that sRAGE may form in vivo complexes with HMGB1 in the sera/synovial fluid of RA patients, leading to inaccurately low levels of sRAGE.
Gene_expression (levels) of sRAGE in synovial fluid associated with rheumatoid arthritis
13) Confidence 0.50 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 1.19 Pain Relevance 0.61
Our aim was to analyse to what extent sRAGE is present in patients with chronic joint inflammation (RA) as compared with patients with non-inflammatory joint disease and with healthy subjects, and to assess whether there is an association between sRAGE levels and disease characteristics.
Gene_expression (levels) of sRAGE in joint associated with inflammation, rheumatoid arthritis, disease, arthropathy and arthritis
14) Confidence 0.50 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1175032 Disease Relevance 1.46 Pain Relevance 0.57
In contrast, the synovial sRAGE levels in RA patients with erosive disease correlated significantly with synovial white blood cell counts (rs = 0.53, P < 0.04), whereas no association was found between synovial fluid sRAGE and synovial IL-6 levels in RA patients.


Neg (no) Gene_expression (found) of sRAGE in white blood cell associated with rheumatoid arthritis and disease
15) Confidence 0.50 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 1.19 Pain Relevance 0.50
In contrast, the synovial sRAGE levels in RA patients with erosive disease correlated significantly with synovial white blood cell counts (rs = 0.53, P < 0.04), whereas no association was found between synovial fluid sRAGE and synovial IL-6 levels in RA patients.


Gene_expression (levels) of sRAGE in white blood cell associated with rheumatoid arthritis and disease
16) Confidence 0.50 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 1.18 Pain Relevance 0.44
Our results indicate, however, that within the age-matched groups (mean age 52.7 ± 10.2 years for RA versus 54.4 ± 9.1 years for controls) up to 65 years of age there was still a major statistical significance regarding circulating sRAGE levels (873 ± 72 pg/ml versus 1290 ± 78 pg/ml, P = 0.0001) (Fig. 3).
Gene_expression (levels) of sRAGE associated with rheumatoid arthritis
17) Confidence 0.50 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.68 Pain Relevance 0.31
HMGB1 expression does not influence sRAGE detection by ELISA
Gene_expression (detection) of sRAGE
18) Confidence 0.50 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.67 Pain Relevance 0.32
Our aim was to evaluate the levels of sRAGE in patients with RA and to assess whether there is an association between sRAGE levels and disease characteristics.
Gene_expression (levels) of sRAGE associated with rheumatoid arthritis and disease
19) Confidence 0.50 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 1.01 Pain Relevance 0.37
The effect of the treatment on sRAGE levels in RA patients
Gene_expression (levels) of sRAGE associated with rheumatoid arthritis
20) Confidence 0.50 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 1.07 Pain Relevance 0.45

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox